
Gene Report
Approved Symbol | RALA |
---|---|
Approved Name | v-ral simian leukemia viral oncogene homolog A (ras related) |
Previous Symbol | RAL |
Name Alias | RAS-like protein A, "Ras-related protein Ral-A", "Ras family small GTP binding protein RALA" |
Location | 7p22-p15 |
Position | chr7:39663152-39747723 (+) |
External Links |
Entrez Gene: 5898 Ensembl: ENSG00000006451 UCSC: uc003thd.3 HGNC ID: 9839 |
No. of Studies (Positive/Negative) | 1(1/0)
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Type | Literature-origin |
Name in Literature | Reference | Research Type | Statistical Result | Relation Description | ![]() |
---|---|---|---|---|---|
RALA | Aston, 2005 | patients and normal controls | Genes altered in major depressive disorder Genes altered in major depressive disorder |
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus | Protein and Other Molecule | Cell and Molecular Pathway | Neural System | Cognition and Behavior | Symptoms and Signs | Environment | MDD |
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2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Approved Name | UniportKB | No. of Studies (Positive/Negative) | Source | |
---|---|---|---|---|
Ras-related protein Ral-A | P11233 | 0(0/0) | Gene mapped |
Literature-origin GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0032553 | ribonucleotide binding | molecular function | IEA | |
GO:0032553 | ribonucleotide binding | molecular function | IEA |
Gene mapped GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0005515 | protein binding | molecular function | IPI[10051605] | |
GO:0031755 | Edg-2 lysophosphatidic acid receptor binding | molecular function | IDA[19306925] | |
GO:0051665 | membrane raft localization | biological process | IDA | |
GO:0031532 | actin cytoskeleton reorganization | biological process | IDA[10051605] | |
GO:0007165 | signal transduction | biological process | TAS[2550440] | |
GO:0005886 | plasma membrane | cellular component | IDA[17875936] | |
GO:0006887 | exocytosis | biological process | IEA | |
GO:0007049 | cell cycle | biological process | IEA | |
GO:0019048 | virus-host interaction | biological process | IEA | |
GO:0000910 | cytokinesis | biological process | IDA[18756269] | |
GO:0017157 | regulation of exocytosis | biological process | IDA | |
GO:0030496 | midbody | cellular component | IEA | |
GO:0007265 | Ras protein signal transduction | biological process | TAS | |
GO:0032154 | cleavage furrow | cellular component | IDA[18756269] | |
GO:0009986 | cell surface | cellular component | IDA[19306925] | |
GO:0005525 | GTP binding | molecular function | IEA | |
GO:0051491 | positive regulation of filopodium assembly | biological process | IDA[10051605] | |
GO:0003924 | GTPase activity | molecular function | IEA | |
GO:0030139 | endocytic vesicle | cellular component | IDA[19306925] | |
GO:0048011 | nerve growth factor receptor signaling pathway | biological process | TAS | |
GO:0006935 | chemotaxis | biological process | TAS[10848592] |
Gene mapped KEGG pathways | ||||
ID | Name | Brief Description | Full Description | |
---|---|---|---|---|
hsa05212 | pancreatic cancer | Pancreatic cancer | Normal duct epithelium progresses to infiltrating cancer thr...... Normal duct epithelium progresses to infiltrating cancer through a series of histologically defined precursors (PanINs). The overexpression of HER-2/neu and activating point mutations in the K-ras gene occur early, inactivation of the p16 gene at an intermediate stage, and the inactivation of p53, SMAD4, and BRCA2 occur relatively late. Activated K-ras engages multiple effector pathways. Although EGF receptors are conventionally regarded as upstream activators of RAS proteins, they can also act as RAS signal transducers via RAS-induced autocrine activation of the EGFR family ligands. Pancreatic ductal adenocarcinoma (PDA) show elevated expression of EGF receptors (e.g. HER2/neu) and their ligands (e.g.TGF-alpha) consistent with the presence of this autocrine loop. Moreover, PDA shows extensive genomic instability and aneuploidy. Telomere attrition and mutations in p53 and BRCA2 are likely to contribute to these phenotypes. Inactivation of the SMAD4 tumour suppressor gene leads to loss of the inhibitory influence of the transforming growth factor-beta signalling pathway. More... | |
hsa05200 | pathways in_cancer | Pathways in cancer |
Gene mapped BioCarta pathways | ||||
ID | Name | Brief Description | Full Description | |
---|---|---|---|---|
RAS_PATHWAY | ras pathway | Ras Signaling Pathway | Ras activates many signaling cascades. Here we illustrate so...... Ras activates many signaling cascades. Here we illustrate some of the well-characterized cascades in a generic compilation of effector molecules. The effectors mediate Ras stimulation to a diverse set of cellular signals. Many of these signals are interpreted differently depending on the cell type or microenvironment receiving the stimulus. Not all of these effectors are activated in any given cell type. The primary method of activation is to promote the translocation of the molecule to the plasma membrane where additional interactions lead to the activation of the molecule. RalGDS is a Guanine Exchange Factor (GEF) for Ral but also has other independent functions. RalGDS activates RalA/B-related small GTPases. RalBP1 is a GTPase activating protein that leads to the inhibition of the Rac and CDC42 GTPases. Ral can also interact with phospholipase D1 (PLD1) that can also be activated by RhoA. Ras stimulation of the lipid kinase activity of PI3K occurs through an interaction with the p110 catalytic subunit. PI3K phosphorylates the D3 position of phosphatidylinositides. In this example Pip2 is converted to PIP3. PIP3 stimulates the AKT/PKB kinase and several of the Rac-GEFs such as Sos1 AND Vav. AKT activation inhibits apoptosis by inhibiting the actions of Bad, Caspase9 and AFX. AKT further hinders apoptosis by phosphorylating the IkB repressor of NFkB. Stimulus of Rac causes among other things the activation of NFkB. Ras also stimulates the mitogen-activated kinases ERK1/2 via the Raf1 cascade. The Erk kinases translocate to the nucleus where they phosphorylate various transcription factors such as ELK1 More... |
Gene mapped Reactome pathways | |||
ID | Name | Description | |
---|---|---|---|
REACT_12056 | trka signalling_from_the_plasma_membrane | Trk receptors signal from the plasma membrane and from intra...... Trk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes is slower but long lasting. Signalling from the plasma membrane is annotated here. TRK signalling leads to proliferation in some cell types and neuronal differentiation in others. Proliferation is the likely outcome of short term signalling, as observed following stimulation of EGFR (EGF receptor). Long term signalling via TRK receptors, instead, was clearly shown to be required for neuronal differentiation in response to neurotrophins. More... | |
REACT_12065 | p38mapk events | NGF induces sustained activation of p38, a member of the MAP...... NGF induces sustained activation of p38, a member of the MAPK family. Both p38 and the ERKs appear to be involved in neurite outgrowth and differentiation caused by NGF in PC12 cells. As a matter of fact, PC12 cell differentiation appears to involve activation of both ERK/MAPK and p38. Both ERK/MAPK and p38 pathways contribute to the phosphorylation of the transcription factor CREB and the activation of immediate-early genes. p38 activation by NGF may occur by at least two mechanisms, involving SRC or MEK kinases. More... | |
REACT_12058 | signalling to_erks | Neurotrophins utilize multiple pathways to activate ERKs (ER...... Neurotrophins utilize multiple pathways to activate ERKs (ERK1 and ERK2), a subgroup of the large MAP kinase (MAPK) family, from the plasma membrane. The major signalling pathways to ERKs are via RAS, ocurring from caveolae in the plasma membrane or from clathrin-coated vesicles, and via RAP1, taking place in early endosomes. Whereas RAS activation by NGF is transient, RAP1 activation by NGF is sustained for hours. More... | |
REACT_11061 | signalling by_ngf | Neurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles i...... Neurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in minute amounts, by a variety of tissues. They signal through two types of receptors: TRK tyrosine kinase receptors (TRKA, TRKB, TRKC), which specifically interact with the different neurotrophins, and p75NTR, which interacts with all neurotrophins. TRK receptors are reported in a variety of tissues in addition to neurons. p75NTRs are also widespread. Neurotrophins and their receptors are synthesized as several different splice variants, which differ in terms of their biological activities. The nerve growth factor (NGF) was the first growth factor to be identified and has served as a model for studying the mechanisms of action of neurotrophins and growth factors. The mechanisms by which NGF generates diverse cellular responses have been studied extensively in the rat pheochromocytoma cell line PC12. When exposed to NGF, PC12 cells exit the cell cycle and differentiate into sympathetic neuron-like cells. Current data show that signalling by the other neurotrophins is similar to NGF signalling. More... | |
REACT_12033 | signalling to_ras | Signalling through Shc adaptor proteins appears to be identi...... Signalling through Shc adaptor proteins appears to be identical for both NGF and EGF. It leads to a fast, but transient, MAPK/ERK activation, which is insufficient to explain the prolonged activation of MAPK found in NGF-treated cells. More... |

Gene | Interactor | Interactor in MK4MDD? | Experiment Type | PMID | |
---|---|---|---|---|---|
RALA | EXOC2 | No | in vitro;in vivo;yeast 2-hybrid | 14525976 , 12624092 , 11744922 , 12839989 | |
RALA | EXOC5 | No | in vitro | 11406615 | |
RALA | EXOC3 | No | in vitro | 11406615 | |
RALA | SMAD4 | No | yeast 2-hybrid | 15231748 | |
RALA | EXOC8 | No | in vitro;in vivo;yeast 2-hybrid | 14525976 , 11406615 | |
RALA | RAB8B | Yes | in vitro;in vivo | 10889189 | |
RALA | RALBP1 | No | in vitro;yeast 2-hybrid | 7673236 | |
RALA | ARF1 | No | in vivo | 12509462 , 9688545 | |
RALA | CSDA | No | in vitro;in vivo;yeast 2-hybrid | 15592429 | |
RALA | EXOC7 | No | in vitro | 11406615 | |
RALA | CALM1 | No | in vitro;in vivo;yeast 2-hybrid | 9188503 | |
RALA | RALGPS1 | No | in vitro;in vivo | 10889189 | |
RALA | FLNA | No | in vitro;in vivo | 10051605 | |
RALA | PLD1 | No | in vitro;in vivo | 9207251 | |
RALA | EXOC4 | No | in vitro | 11406615 | |
RALA | RGL4 | No | in vitro | 12874025 | |
RALA | REPS1 | No | in vitro;yeast 2-hybrid | 7623849 | |
RALA | CNKSR2 | No | in vivo | 14597674 | |
RALA | EXOC1 | No | in vitro | 11406615 | |
RALA | PPP2R1B | No | in vivo | 17540176 | |
RALA | RASSF5 | No | yeast 2-hybrid | 9488663 | |
RALA | EXOC6B | No | in vitro | 11406615 | |
RALA | PLCD1 | No | in vitro;yeast 2-hybrid | 15817490 |