Gene Report

Basic Information

Approved Symbol	RRAS2
Approved Name	related RAS viral (r-ras) oncogene homolog 2
Symbol Alias	TC21
Location	11p15.2
Position	chr11:14385940-14386052 (-)
External Links	Entrez Gene: 22800 Ensembl: ENSG00000133818 UCSC: uc001mlf.4 HGNC ID: 17271
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between RRAS2 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
TC21	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between RRAS2 and other components at different levels (count: 0)

Positive relationship network of RRAS2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between RRAS2 and MDD (count: 0)

Negative relationships between RRAS2 and other components at different levels (count: 0)

RRAS2 related SNPs in MK4MDD (count: 0)

RRAS2 related proteins in MK4MDD (count: 0)

RRAS2 related GO terms (count: 20)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:1901214	regulation of neuron death	biological process	IMP[21085126]
GO:0005525	GTP binding	molecular function	IEA
GO:0005515	protein binding	molecular function	IPI[12620389]
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0001649	osteoblast differentiation	biological process	IDA[16210410]
GO:0005783	endoplasmic reticulum	cellular component	NAS[10777492]
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0070062	extracellular exosome	cellular component	IDA[19056867]
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0005886	plasma membrane	cellular component	IEA
GO:0016020	membrane	cellular component	IDA[16210410]
GO:0007265	Ras protein signal transduction	biological process	IEA
GO:0005925	focal adhesion	cellular component	IDA[21423176]
GO:0030335	positive regulation of cell migration	biological process	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0003924	GTPase activity	molecular function	TAS[10777492]

RRAS2 related KEGG pathways (count: 3)

ID	Name	Brief Description	Full Description
Literature-origin KEGG pathway
hsa04810	regulation of_actin_cytoskeleton	Regulation of actin cytoskeleton
hsa04530	tight junction	Tight junction	Epithelial tight junctions (TJs) are composed of at least th...... Epithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. The transmembrane proteins mediate cell adhesion and are thought to constitute the intramembrane and paracellular diffusion barriers. The cytoplasmic 'plaque' contains three major multi-protein complexes consisting largely of scaffolding proteins, the ZO protein complex, the CRB3-Pals1-PATJ complex and the PAR-3-aPKC-PAR-6 complex. The ZO protein complex appears to organize the transmembrane proteins and couple them to other cytoplasmic proteins and to actin microfilaments. Two evolutionarily conserved protein complexes, the CRB3 and PAR complexes are involved in the establishment and maintenance of epithelial cell polarity. Besides these three protein complexes which seem to be constitutively associated at TJs, a number of proteins with different functions has been identified at TJs. These include additional scaffolding proteins like MUPP1 and MAGI-1, adaptor proteins, transcription regulators and RNA processing factors, regulatory proteins like small GTPases and G-proteins, kinases and phosphatases, and heat shock proteins. These are proposed to be involved in junction assembly, barrier regulation, gene transcription, and perhaps other, presently undefined pathways. More...

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04010	mapk signaling_pathway	MAPK signaling pathway	The mitogen-activated protein kinase (MAPK) cascade is a hig...... The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. More...

RRAS2 related BioCarta pathways (count: 0)

RRAS2 related Reactome pathways (count: 0)

RRAS2 related interactors from protein-protein interaction data in HPRD (count: 27)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
RRAS2	RAPGEF4	No	in vitro	12384139
RRAS2	RASSF5	No	in vitro	11857081
RRAS2	PTPN1	Yes	in vitro	11788587
RRAS2	SMAD4	No	in vivo	15761153
RRAS2	RIN1	No	in vivo;yeast 2-hybrid	11788587
RRAS2	PIK3R1	Yes	in vivo	11850823
RRAS2	RASIP1	No	yeast 2-hybrid	15031288
RRAS2	RALGDS	No	in vitro;in vivo;yeast 2-hybrid	11788587
RRAS2	RAPGEF1	No	in vitro	12384139
RRAS2	ARHGEF2	Yes	in vitro	12384139
RRAS2	RAF1	No	in vivo;yeast 2-hybrid	10064593 , 11788587
RRAS2	ARAF	No	yeast 2-hybrid	12620389
RRAS2	SMAD3	No	in vivo	15761153
RRAS2	XRCC6	No	yeast 2-hybrid	16169070
RRAS2	AHSG	No	in vitro	11788587
RRAS2	PAWR	Yes	yeast 2-hybrid	16169070
RRAS2	BMPR1B	No	in vivo	15761153
RRAS2	FNTB	Yes	in vitro	15451670
RRAS2	TRAF3	No	in vitro;in vivo	10557073
RRAS2	SMURF2	No	in vivo	15761153
RRAS2	RAPGEF3	No	in vitro	12384139
RRAS2	ACVR1	No	in vivo	15761153
RRAS2	PGGT1B	No	in vitro	15451670
RRAS2	LGALS4	No	yeast 2-hybrid	16169070
RRAS2	MLLT4	No	in vitro;yeast 2-hybrid	11788587 , 10224125
RRAS2	RASGRF1	Yes	in vitro	12384139
RRAS2	RABAC1	No	in vivo;yeast 2-hybrid	11335720

Gene Report

Gene mapped GO terms

Literature-origin KEGG pathway

Gene mapped KEGG pathways