Gene Report

Basic Information

Approved Symbol	FNTB
Approved Name	farnesyltransferase, CAAX box, beta
Symbol Alias	FPTB
Location	14q23.3
Position	chr14:65528031-65529370 (+)
External Links	Entrez Gene: 2342 Ensembl: ENSG00000257365 HGNC ID: 3785
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between FNTB and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Farnesyltransferase, CAAX box, beta	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between FNTB and other components at different levels (count: 0)

Positive relationship network of FNTB in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between FNTB and MDD (count: 0)

Negative relationships between FNTB and other components at different levels (count: 0)

FNTB related SNPs in MK4MDD (count: 0)

FNTB related proteins in MK4MDD (count: 0)

FNTB related GO terms (count: 22)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005829	cytosol	cellular component	TAS
GO:0004660	protein farnesyltransferase activity	molecular function	IDA[16893176]; IDA[19228685]
GO:0005515	protein binding	molecular function	IPI[11687658\|12036349\|12825937\|15170324\|15248757\|15451670]
GO:0018343	protein farnesylation	biological process	IDA[16893176\|19228685]
GO:0042277	peptide binding	molecular function	IEA
GO:0005965	protein farnesyltransferase complex	cellular component	IDA[16893176]
GO:0014070	response to organic cyclic compound	biological process	IEA
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	biological process	IEA
GO:0042060	wound healing	biological process	IEA
GO:0022400	regulation of rhodopsin mediated signaling pathway	biological process	TAS
GO:0004311	farnesyltranstransferase activity	molecular function	IEA
GO:0008144	drug binding	molecular function	IEA
GO:0005875	microtubule associated complex	cellular component	IDA[19228685]
GO:0010035	response to inorganic substance	biological process	IEA
GO:0008285	negative regulation of cell proliferation	biological process	IEA
GO:0048146	positive regulation of fibroblast proliferation	biological process	IEA
GO:0008270	zinc ion binding	molecular function	IDA[16893176]
GO:0019840	isoprenoid binding	molecular function	IEA
GO:0016056	rhodopsin mediated signaling pathway	biological process	TAS
GO:0034097	response to cytokine	biological process	IEA
GO:0007603	phototransduction, visible light	biological process	TAS
GO:0045787	positive regulation of cell cycle	biological process	IEA

FNTB related KEGG pathways (count: 0)

FNTB related BioCarta pathways (count: 0)

FNTB related Reactome pathways (count: 0)

FNTB related interactors from protein-protein interaction data in HPRD (count: 8)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
FNTB	KRAS	No	in vitro	12374986
FNTB	PTP4A3	Yes	in vitro	10747914
FNTB	GBP1	No	in vitro	8830800 , 11598000 , 10676968
FNTB	FNTA	No	in vitro	12825937 , 12036349
FNTB	HRAS	No	in vitro	2217184 , 15451670
FNTB	RRAS2	Yes	in vitro	15451670
FNTB	CENPF	No	in vitro	10852915
FNTB	RAP2A	No	in vitro	15451670

Gene Report

Gene mapped GO terms