Gene Report

Basic Information

Approved Symbol	UBE2A
Approved Name	ubiquitin-conjugating enzyme E2A
Previous Name	ubiquitin-conjugating enzyme E2A (RAD6 homolog)
Symbol Alias	UBC2, HHR6A, RAD6A
Location	Xq24
Position	chrX:118708499-118718381 (+)
External Links	Entrez Gene: 7319 Ensembl: ENSG00000077721 UCSC: uc004erl.3 HGNC ID: 12472
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between UBE2A and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
UBE2A	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between UBE2A and other components at different levels (count: 0)

Positive relationship network of UBE2A in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between UBE2A and MDD (count: 0)

Negative relationships between UBE2A and other components at different levels (count: 0)

UBE2A related SNPs in MK4MDD (count: 0)

UBE2A related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Ubiquitin-conjugating enzyme E2 A	P49459	0(0/0)	Gene mapped

UBE2A related GO terms (count: 24)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	biological process	TAS
GO:0001701	in utero embryonic development	biological process	IEA
GO:0033503	HULC complex	cellular component	IDA[19410543]
GO:0000209	protein polyubiquitination	biological process	TAS
GO:0005829	cytosol	cellular component	TAS
GO:0004842	ubiquitin-protein ligase activity	molecular function	IDA
GO:0051865	protein autoubiquitination	biological process	IDA[11953320]
GO:0070979	protein K11-linked ubiquitination	biological process	IDA
GO:0005515	protein binding	molecular function	IPI
GO:0001741	XY body	cellular component	IEA
GO:0000785	chromatin	cellular component	ISS
GO:0070936	protein K48-linked ubiquitination	biological process	IDA
GO:0031625	ubiquitin protein ligase binding	molecular function	IPI[10908344]
GO:0006511	ubiquitin-dependent protein catabolic process	biological process	NAS[1559696]
GO:0006281	DNA repair	biological process	IGI[1717990]
GO:0006301	postreplication repair	biological process	NAS[1559696]
GO:0000790	nuclear chromatin	cellular component	IEA
GO:0033522	histone H2A ubiquitination	biological process	IDA[11953320]
GO:0009411	response to UV	biological process	IGI[1717990]
GO:0005524	ATP binding	molecular function	IEA
GO:0008284	positive regulation of cell proliferation	biological process	IDA[11953320]
GO:0060135	maternal process involved in female pregnancy	biological process	IEA

UBE2A related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04120	ubiquitin mediated_proteolysis	Ubiquitin mediated proteolysis	Protein ubiquitination plays an important role in eukaryotic...... Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates. More...

UBE2A related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
PROTEASOME_PATHWAY	proteasome pathway	Proteasome Complex	Attachment of the ubiquitin peptide to proteins targets them...... Attachment of the ubiquitin peptide to proteins targets them for proteolytic degradation by a complex cellular structure, the proteasome. The regulated proteolysis of proteins by proteasomes removes denatured, damaged or improperly translated proteins from cells and regulates the level of proteins like cyclins or some transcription factors. E1 and E2 enzymes prepare ubiquitin chains that are then attached to proteins by the E3 enzyme. The sequence of ubiquitin and the basic structure and function of the proteasome are highly conserved. The core proteasome in man (20S proteasome) consists of four rings each with 14 subunits stacked on top of each other that are responsible for the proteolytic activity of the proteasome. The PA700 regulatory complex is stacked on the ends of the cylindrical core to form a 26S proteasome. Proteins that are tagged with ubiquitin are recognized and bound by the regulatory subunits, then unfolded in an ATP-dependent manner, and inserted into the core particle, where proteases degrade the protein, releasing small peptides and releasing the ubiquitin intact. The PA28 regulatory complex is alternative regulatory complex that appears to play a role in antigen processing for presentation of peptides to immune cells in the MHC I complex. More...

UBE2A related Reactome pathways (count: 0)

UBE2A related interactors from protein-protein interaction data in HPRD (count: 7)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
UBE2A	TP53	No	in vivo	12640129
UBE2A	CDKN2A	No	in vivo	12640129
UBE2A	CDK2	No	in vivo	11953320
UBE2A	ZMYM2	No	in vitro;in vivo;yeast 2-hybrid	12776193
UBE2A	CDK1	No	in vivo	11953320
UBE2A	MDM2	No	in vivo	12640129
UBE2A	RAD18	No	in vivo;yeast 2-hybrid	10908344 , 10884424

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped BioCarta pathways