Gene Report

Basic Information

Approved Symbol	REV3L
Approved Name	REV3-like, polymerase (DNA directed), zeta, catalytic subunit
Previous Name	REV3 (yeast homolog)-like, catalytic subunit of DNA polymerase zeta, "REV3-like, catalytic subunit of DNA polymerase zeta (yeast)"
Symbol Alias	POLZ, REV3
Name Alias	polymerase, DNA, zeta
Location	6q22
Position	chr6:111620234-111804414 (-)
External Links	Entrez Gene: 5980 Ensembl: ENSG00000009413 UCSC: uc003puy.4 HGNC ID: 9968
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between REV3L and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
REV3L	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between REV3L and other components at different levels (count: 0)

Positive relationship network of REV3L in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between REV3L and MDD (count: 0)

Negative relationships between REV3L and other components at different levels (count: 0)

REV3L related SNPs in MK4MDD (count: 0)

REV3L related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
DNA polymerase zeta catalytic subunit	O60673	0(0/0)	Gene mapped

REV3L related GO terms (count: 12)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0000166	nucleotide binding	molecular function	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0016035	zeta DNA polymerase complex	cellular component	IDA
GO:0005634	nucleus	cellular component	IBA
GO:0003677	DNA binding	molecular function	IEA
GO:0008408	3'-5' exonuclease activity	molecular function	IBA
GO:0046872	metal ion binding	molecular function	IEA
GO:0006261	DNA-dependent DNA replication	biological process	TAS[9618506]
GO:0019985	translesion synthesis	biological process	IBA
GO:0003887	DNA-directed DNA polymerase activity	molecular function	IBA
GO:0051539	4 iron, 4 sulfur cluster binding	molecular function	IEA
GO:0006297	nucleotide-excision repair, DNA gap filling	biological process	IBA
GO:0005694	chromosome	cellular component	IBA

REV3L related KEGG pathways (count: 0)

REV3L related BioCarta pathways (count: 0)

REV3L related Reactome pathways (count: 1)

ID	Name	Description
Gene mapped Reactome pathways
REACT_216	dna repair	DNA repair is a phenomenal multi-enzyme, multi-pathway syste...... DNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. These cellular mechanisms that must cope with the plethora of DNA base pair adducts that arise. DNA damage can arise spontaneously in the cellular milieu through chemical alteration of base nucleotides or as a consequence of errors during DNA replication. For example, it is well known that normal cellular pH and temperature offer an environment, which is hostile to the integrity of DNA and its nucleotide components. Additionally, DNA damage may be induced in response to environmental exposures, including exposure to physical agents such as ionizing or ultraviolet (UV) radiation. Finally, specific chemical agents are known to alkylate or cross-link DNA bases, produce bulky adducts on DNA bases, or break DNA phosphate-sugar backbone. The pioneering work from a number of laboratories have elucidated the basic mechanisms underlying distinct DNA repair pathways that include nucleotide excision repair (NER), base excision repair (BER), DNA strand break repair (DSBR), direct reversal of DNA damage, and the replication past DNA lesions by specialized DNA bypass polymerases (bypass replication). Defects in most of these repair pathways have been associated with one or more specific human diseases. Additionally, the repair of damaged DNA is intimately associated with a number of other distinct cellular processes such as DNA replication, DNA recombination, cell cycle checkpoint arrest, and other basic cellular mechanisms as outlined herein. More...

REV3L related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
REV3L	MAD2L2	No	in vitro;in vivo;yeast 2-hybrid	11485998 , 10660610
REV3L	REV1	No	yeast 2-hybrid	15189446
REV3L	HDAC4	No	yeast 2-hybrid	15964851

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped Reactome pathways