Gene Report

Basic Information

Approved Symbol	KLRC3
Approved Name	killer cell lectin-like receptor subfamily C, member 3
Symbol Alias	NKG2-E
Location	12p13
Position	chr12:10564914-10573194 (-)
External Links	Entrez Gene: 3823 Ensembl: ENSG00000205810 HGNC ID: 6376
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between KLRC3 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
KLRC3	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between KLRC3 and other components at different levels (count: 0)

Positive relationship network of KLRC3 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between KLRC3 and MDD (count: 0)

Negative relationships between KLRC3 and other components at different levels (count: 0)

KLRC3 related SNPs in MK4MDD (count: 0)

KLRC3 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
NKG2-E type II integral membrane protein	Q07444	0(0/0)	Gene mapped

KLRC3 related GO terms (count: 4)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0006968	cellular defense response	biological process	TAS[9683661]
GO:0016021	integral to membrane	cellular component	IEA
GO:0004888	transmembrane signaling receptor activity	molecular function	TAS[9683661]
GO:0030246	carbohydrate binding	molecular function	IEA

KLRC3 related KEGG pathways (count: 2)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04612	antigen processing_and_presentation	Antigen processing and presentation
hsa04650	natural killer_cell_mediated_cytotoxicity	Natural killer cell mediated cytotoxicity	Natural killer (NK) cells are lymphocytes of the innate immu...... Natural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stress, such as infection with viruses, bacteria, or parasites or malignant transformation. Although NK cells do not express classical antigen receptors of the immunoglobulin gene family, such as the antibodies produced by B cells or the T cell receptor expressed by T cells, they are equipped with various receptors whose engagement allows them to discriminate between target and nontarget cells. Activating receptors bind ligands on the target cell surface and trigger NK cell activation and target cell lysis. However Inhibitory receptors recognize MHC class I molecules (HLA) and inhibit killing by NK cells by overruling the actions of the activating receptors. This inhibitory signal is lost when the target cells do not express MHC class I and perhaps also in cells infected with virus, which might inhibit MHC class I exprssion or alter its conformation. The mechanism of NK cell killing is the same as that used by the cytotoxic T cells generated in an adaptive immune response; cytotoxic granules are released onto the surface of the bound target cell, and the effector proteins they contain penetrate the cell membrane and induce programmed cell death. More...

KLRC3 related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
NKCELLS_PATHWAY	nkcells pathway	Ras-Independent pathway in NK cell-mediated cytotoxicity	NK (natural killer) cells are lymphocytes distinct from B an...... NK (natural killer) cells are lymphocytes distinct from B and T cells that induce perforin-mediated lysis of tumor cells and virus-infected cells. NK cell-mediated cytotoxicity is activated by glycoproteins on the cell surface (activating receptors) and inhibited by MHC-1 with self-peptide bound. The MHC-1 inhibitory signal through Ig-family or lectin receptors prevents NK cells from killing normal cells. Abnormal MHC-1 expression in infected or tumor cells results in the release of perforin, the lysis of the abnormal cell and the release of cytokines that stimulate the immune response. MAP kinase inhibitors but not ras inhibitors are able to block NK cell cytotoxicity, indicating that the pathway can function by a ras-independent manner that involves the MAP kinase pathway. This pathway includes phosphoinositide-3-kinase (PI3K) as a key component, followed by Rac1 and the exchange factor Vav. The tyrosine kinase SYK and LAT may provide an additional pathway for activation of MAP kinases leading to NK cell activation, and also Pyk-2 activation by integrins. The protein tyrosine phosphatase SHP-1 appears to mediate the cytotoxicity inhibitory signal that blocks lysis of normal cells. The balance of these positive and negative signaling pathways regulates the role of NK cells in the immune response. More...

KLRC3 related Reactome pathways (count: 0)

KLRC3 related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
KLRC3	TYROBP	No	in vivo	10201920
KLRC3	KLRD1	No	in vivo	8943374 , 10201920

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped BioCarta pathways