Gene Report

Basic Information

Approved Symbol	PPP2R3A
Approved Name	protein phosphatase 2, regulatory subunit B'', alpha
Previous Symbol	PPP2R3
Previous Name	protein phosphatase 2 (formerly 2A), regulatory subunit B'' (PR 72), alpha isoform and (PR 130), beta isoform, "protein phosphatase 2 (formerly 2A), regulatory subunit B'', alpha"
Location	3q22.2-q22.3
Position	chr3:135684515-135866752 (+)
External Links	Entrez Gene: 5523 Ensembl: ENSG00000073711 UCSC: uc003eqv.2 HGNC ID: 9307
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between PPP2R3A and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
PPP2R3	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between PPP2R3A and other components at different levels (count: 0)

Positive relationship network of PPP2R3A in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between PPP2R3A and MDD (count: 0)

Negative relationships between PPP2R3A and other components at different levels (count: 0)

PPP2R3A related SNPs in MK4MDD (count: 0)

PPP2R3A related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha	Q06190	0(0/0)	Gene mapped

PPP2R3A related GO terms (count: 13)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0090263	positive regulation of canonical Wnt receptor signaling pathway	biological process	IDA[16567647]
GO:0005515	protein binding	molecular function	IPI[15687260]
GO:0001754	eye photoreceptor cell differentiation	biological process	IGI[15687260]
GO:0005509	calcium ion binding	molecular function	IEA
GO:0008601	protein phosphatase type 2A regulator activity	molecular function	TAS[8392071]
GO:0006470	protein dephosphorylation	biological process	ISS[1849734]
GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	biological process	IGI[15687260]
GO:0061053	somite development	biological process	ISS[16567647]
GO:0045732	positive regulation of protein catabolic process	biological process	IMP[15687260]
GO:0090249	regulation of cell motility involved in somitogenic axis elongation	biological process	IGI[15687260]
GO:0007525	somatic muscle development	biological process	IGI[15687260]
GO:0090244	Wnt receptor signaling pathway involved in somitogenesis	biological process	IC[15687260]
GO:0000159	protein phosphatase type 2A complex	cellular component	IDA[17055435]; IDA[15687260]; ISS[1849734]

PPP2R3A related KEGG pathways (count: 0)

PPP2R3A related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
CHREBP2_PATHWAY	chrebp2 pathway	Regulation And Function Of ChREBP in Liver	Liver is the major site for carbohydrate metabolism (glycoly...... Liver is the major site for carbohydrate metabolism (glycolysis and glycogen synthesis) and triglyceride synthesis (lipogenesis). While insulin was long thought to be the major regulator of hepatic gene expression, emerging evidence show that nutrients, in particular, glucose and fatty acids, are also able to regulate hepatic genes. This diagram illustrates how glucose metabolite, rather than glucose itself, contributes to the coordinated regulation of carbohydrate and lipid homeostasis in liver through phosphorylation-dependent regulation of ChREBP (carbohydrate responsive element binding protein). ChREBP is a basic helix-loop helix/leucine zipper (bHLH/LZ) transcription factor, shuttling between the cytoplasm and nucleus in a glucose-responsive manner in hepatocytes. When serum glucose is elevated, glucose transporter (GLUT2) and glucokinase (GCK) allow for rapid uptake and equilibration of intracellular glucose levels. This flux of glucose promotes, via the hexose monophosphate shunt pathway (HMP Shunt), the formation of xylulose-5-phosphate (Xu-5-P), which activates protein phosphatase 2A (PP2A) to dephosphorylate ChREBP (Ser196) and promote its nuclear localization. PP2A further dephosphorylates ChREBP in the nucleus, allowing it to dimerize with the bHLH/LZ transcription factor Max-like protein X (MLX) and activate transcription of a number of glycolytic and lipogenic genes containing a ChoRE, such as liver-type pyruvate kinase (L-PK), acetyl-CoA carboxylase 1 (ACACA), and fatty acid synthase (FASN). Upon starvation or high-fat feeding, intrahepatic levels of cAMP and AMP are elevated to activate protein kinase A (PKA) and AMP-dependent protein kinase (AMPK), respectively. PKA-mediated phosphorylation of Thr666 and Ser626 inhibits the DNA binding capacity of ChREBP; so does AMPK-mediated modification of Ser568. PKA-dependent phosphorylation of Ser196 promotes interaction with 14-3-3 and thus sequesters ChREBP in the cytosol. In summary, the phosphorylated form of ChREBP is rendered inactive due to its diminished DNA binding capacity and subcellular compartmentalization. Glucose metabolism triggers dephosphorylation of ChREBP, allowing it to enter the nucleus and activate the transcription of both glycolytic and lipogenic gene expression in liver. The fact that ChREBP/ mice are intolerant to glucose and insulin resistant suggests that ChREBP may also play a role in the pathogenesis of type 2 diabetes. More...

PPP2R3A related Reactome pathways (count: 0)

PPP2R3A related interactors from protein-protein interaction data in HPRD (count: 7)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
PPP2R3A	RBL1	No	in vitro;in vivo	9927208
PPP2R3A	HMGB1	No	in vitro	11748221
PPP2R3A	AKAP9	No	in vitro	10358086
PPP2R3A	ATXN7L2	No	yeast 2-hybrid	16713569
PPP2R3A	PPP5C	No	in vivo	11504734
PPP2R3A	PPP2R3A	Yes	in vivo	8392071
PPP2R3A	CDC6	No	yeast 2-hybrid	10629059

Gene Report

Gene mapped GO terms

Gene mapped BioCarta pathways