Gene Report

Basic Information

Approved Symbol	MYO9B
Approved Name	myosin IXB
Previous Symbol	CELIAC4
Location	19p13.1
Position	chr19:17323120-17324100 (+)
External Links	Entrez Gene: 4650 Ensembl: ENSG00000099331 UCSC: uc010eak.3 HGNC ID: 7609
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between MYO9B and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
MYO9B	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between MYO9B and other components at different levels (count: 0)

Positive relationship network of MYO9B in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between MYO9B and MDD (count: 0)

Negative relationships between MYO9B and other components at different levels (count: 0)

MYO9B related SNPs in MK4MDD (count: 0)

MYO9B related proteins in MK4MDD (count: 0)

MYO9B related GO terms (count: 37)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0008152	metabolic process	biological process	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0031941	filamentous actin	cellular component	IDA[8907710\|16338935\|16616011]
GO:0005524	ATP binding	molecular function	IDA[16338935]
GO:0005515	protein binding	molecular function	IPI[15644318\|16417406]
GO:0030010	establishment of cell polarity	biological process	IEA
GO:0032553	ribonucleotide binding	molecular function	IDA[16338935]
GO:0032553	ribonucleotide binding	molecular function	IDA[16338935]
GO:0016459	myosin complex	cellular component	IEA
GO:0048246	macrophage chemotaxis	biological process	IEA
GO:0003779	actin binding	molecular function	IDA[9490638\|16338935\|16616011]
GO:0072673	lamellipodium morphogenesis	biological process	IEA
GO:0007264	small GTPase mediated signal transduction	biological process	TAS
GO:0042803	protein homodimerization activity	molecular function	IDA[11901422]
GO:0002548	monocyte chemotaxis	biological process	IEA
GO:0048471	perinuclear region of cytoplasm	cellular component	IDA[8907710]
GO:0005096	GTPase activator activity	molecular function	IDA[9490638\|15644318]
GO:0005737	cytoplasm	cellular component	IDA[8907710]
GO:0030027	lamellipodium	cellular component	IEA
GO:0005938	cell cortex	cellular component	IDA[8907710]
GO:0016887	ATPase activity	molecular function	IDA[16338935]
GO:0015629	actin cytoskeleton	cellular component	TAS[8907710]
GO:0016020	membrane	cellular component	IDA[19946888]
GO:0008270	zinc ion binding	molecular function	IEA
GO:0051015	actin filament binding	molecular function	IEA
GO:0043547	positive regulation of GTPase activity	biological process	IEA
GO:0001726	ruffle	cellular component	IEA
GO:0005829	cytosol	cellular component	TAS
GO:0030898	actin-dependent ATPase activity	molecular function	IEA
GO:0043531	ADP binding	molecular function	IDA[16338935]
GO:0000146	microfilament motor activity	molecular function	IDA[9490638\|11901422\|16616011]
GO:0032433	filopodium tip	cellular component	IEA
GO:0043008	ATP-dependent protein binding	molecular function	IEA
GO:0032011	ARF protein signal transduction	biological process	IDA[15644318]
GO:0030048	actin filament-based movement	biological process	TAS[8907710]
GO:0007266	Rho protein signal transduction	biological process	IC[9490638]
GO:0005516	calmodulin binding	molecular function	IDA[9490638\|16338935]
GO:0051056	regulation of small GTPase mediated signal transduction	biological process	TAS

MYO9B related KEGG pathways (count: 0)

MYO9B related BioCarta pathways (count: 0)

MYO9B related Reactome pathways (count: 1)

Gene mapped Reactome pathways
ID	Name	Description
REACT_11051	rho gtpase_cycle	The cycling of Rho GTPases is tightly controlled by three cl...... The cycling of Rho GTPases is tightly controlled by three classes of protein. These are. More...

MYO9B related interactors from protein-protein interaction data in HPRD (count: 5)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
MYO9B	ACTA1	No	in vitro	9490638
MYO9B	ARFGEF1	No	in vitro;yeast 2-hybrid	15644318
MYO9B	CALM1	Yes	in vitro	9490638
MYO9B	MOBKL3	No	yeast 2-hybrid	16169070
MYO9B	LRRC41	No	yeast 2-hybrid	16169070

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped Reactome pathways