Gene Report

Basic Information

Approved Symbol	BCAT1
Approved Name	branched chain amino-acid transaminase 1, cytosolic
Previous Symbol	BCT1
Previous Name	branched chain aminotransferase 1, cytosolic
Location	12p12.1
Position	chr12:24962958-25102393 (-)
External Links	Entrez Gene: 586 Ensembl: ENSG00000060982 UCSC: uc010six.2 HGNC ID: 976
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between BCAT1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
BCAT1	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between BCAT1 and other components at different levels (count: 0)

Positive relationship network of BCAT1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between BCAT1 and MDD (count: 0)

Negative relationships between BCAT1 and other components at different levels (count: 0)

BCAT1 related SNPs in MK4MDD (count: 0)

BCAT1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Branched-chain-amino-acid aminotransferase, cytosolic	P54687	0(0/0)	Gene mapped

BCAT1 related GO terms (count: 11)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0044281	small molecule metabolic process	biological process	TAS
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS
GO:0052656	L-isoleucine transaminase activity	molecular function	IEA
GO:0000082	G1/S transition of mitotic cell cycle	biological process	TAS[8692959]
GO:0008283	cell proliferation	biological process	TAS[6933702]
GO:0052655	L-valine transaminase activity	molecular function	IEA
GO:0009082	branched-chain amino acid biosynthetic process	biological process	IEA
GO:0052654	L-leucine transaminase activity	molecular function	IEA
GO:0005829	cytosol	cellular component	TAS
GO:0004084	branched-chain-amino-acid transaminase activity	molecular function	EXP
GO:0009083	branched-chain amino acid catabolic process	biological process	TAS

BCAT1 related KEGG pathways (count: 3)

ID	Name	Brief Description
Gene mapped KEGG pathways
hsa00290	valine leucine_and_isoleucine_biosynthesis	Valine, leucine and isoleucine biosynthesis
hsa00770	pantothenate and_coa_biosynthesis	Pantothenate and CoA biosynthesis
hsa00280	valine leucine_and_isoleucine_degradation	Valine, leucine and isoleucine degradation

BCAT1 related BioCarta pathways (count: 0)

BCAT1 related Reactome pathways (count: 2)

ID	Name	Description
Gene mapped Reactome pathways
REACT_13	metabolism of_amino_acids	This group of reactions is responsible for: 1) the breakdown...... This group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amino acids that are not essential components of the human diet; and 4) the synthesis of related nitrogen-containing molecules including carnitine and creatine. More...
REACT_197	branched chain_amino_acid_catabolism	The branched-chain amino acids, leucine, isoleucine, and val...... The branched-chain amino acids, leucine, isoleucine, and valine, are all essential amino acids. More...

BCAT1 related interactors from protein-protein interaction data in HPRD (count: 1)

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways