Gene Report

Basic Information

Approved Symbol	MX1
Approved Name	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
Previous Name	myxovirus (influenza) resistance 1, homolog of murine (interferon-inducible protein p78)
Symbol Alias	IFI-78K, MxA
Location	21q22.3
Position	chr21:42792520-42831141 (+)
External Links	Entrez Gene: 4599 Ensembl: ENSG00000157601 UCSC: uc010goq.3 HGNC ID: 7532
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between MX1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
MX1	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between MX1 and other components at different levels (count: 0)

Positive relationship network of MX1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between MX1 and MDD (count: 0)

Negative relationships between MX1 and other components at different levels (count: 0)

MX1 related SNPs in MK4MDD (count: 0)

MX1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Interferon-induced GTP-binding protein Mx1	P20591	0(0/0)	Gene mapped

MX1 related GO terms (count: 21)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0003924	GTPase activity	molecular function	IEA
GO:0005829	cytosol	cellular component	IDA[16780588]; TAS
GO:0034340	response to type I interferon	biological process	TAS
GO:0005515	protein binding	molecular function	IPI[15757897]
GO:0005789	endoplasmic reticulum membrane	cellular component	IEA
GO:0045087	innate immune response	biological process	TAS[16202617]
GO:0005525	GTP binding	molecular function	IEA
GO:0060337	type I interferon-mediated signaling pathway	biological process	TAS
GO:0006917	induction of apoptosis	biological process	TAS[9389754]
GO:0005634	nucleus	cellular component	IEA
GO:0019221	cytokine-mediated signaling pathway	biological process	TAS
GO:0051607	defense response to virus	biological process	IEA
GO:0005737	cytoplasm	cellular component	IDA
GO:0006952	defense response	biological process	TAS[2154602]
GO:0045071	negative regulation of viral genome replication	biological process	IDA[16202617]
GO:0007165	signal transduction	biological process	TAS[9389754]
GO:0048471	perinuclear region of cytoplasm	cellular component	IDA[15047845]
GO:0009615	response to virus	biological process	IMP[15047845]

MX1 related KEGG pathways (count: 0)

MX1 related BioCarta pathways (count: 0)

MX1 related Reactome pathways (count: 0)

MX1 related interactors from protein-protein interaction data in HPRD (count: 11)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
MX1	BLM	No	yeast 2-hybrid	11716541
MX1	TRPC4	No	in vitro;in vivo	15757897
MX1	MX1	Yes	in vitro;in vivo	9060610 , 9735310
MX1	TUBB	No	in vivo	1629950
MX1	TRPC3	No	in vitro;in vivo	15757897
MX1	TRPC7	No	in vitro;in vivo	15757897
MX1	ACTB	No	in vivo	1629950
MX1	TRPC1	No	in vitro;in vivo	15757897
MX1	TRPC5	No	in vitro;in vivo	15757897
MX1	DAXX	No	in vitro;yeast 2-hybrid	11716541
MX1	TRPC6	No	in vitro;in vivo	15757897

Gene Report

Literature-origin GO terms

Gene mapped GO terms