Gene Report

Basic Information

Approved Symbol	GPR37
Approved Name	G protein-coupled receptor 37 (endothelin receptor type B-like)
Symbol Alias	EDNRBL, hET(B)R-LP, PAELR
Location	7q31
Position	chr7:124405031-124406079 (-)
External Links	Entrez Gene: 2861 Ensembl: ENSG00000170775 UCSC: uc003vli.4 HGNC ID: 4494
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin

Positive relationships between GPR37 and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
GPR37	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder
GPR37	Tomita H, 2013	patients and normal controls		GPLS genes significantly dysregulated in anterior cingulate ...... GPLS genes significantly dysregulated in anterior cingulate cortex by microarray More...

Positive relationships between GPR37 and other components at different levels (count: 0)

Positive relationship network of GPR37 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between GPR37 and MDD (count: 0)

Negative relationships between GPR37 and other components at different levels (count: 0)

GPR37 related SNPs in MK4MDD (count: 0)

GPR37 related proteins in MK4MDD (count: 0)

GPR37 related GO terms (count: 21)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005887	integral component of plasma membrane	cellular component	TAS[9144577]
GO:0004930	G-protein coupled receptor activity	molecular function	TAS[9144577]
GO:0031987	locomotion involved in locomotory behavior	biological process	IEA
GO:1903206	negative regulation of hydrogen peroxide-induced cell death	biological process	ISS[23690594]
GO:0005783	endoplasmic reticulum	cellular component	IDA[17059562]
GO:0008528	G-protein coupled peptide receptor activity	molecular function	IDA[23690594]
GO:0031625	ubiquitin protein ligase binding	molecular function	IPI[11439185\|12150907\|17059562]
GO:0043410	positive regulation of MAPK cascade	biological process	IDA[23690594]
GO:0043235	receptor complex	cellular component	IDA[23382219]
GO:0005515	protein binding	molecular function	IPI[14532270]
GO:0036505	prosaposin receptor activity	molecular function	IDA[23690594]
GO:0045964	positive regulation of dopamine metabolic process	biological process	IEA
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	biological process	IDA[23690594]
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[9144577]
GO:0042277	peptide binding	molecular function	IPI[23690594]
GO:0005886	plasma membrane	cellular component	IDA[11439185\|12150907]; TAS
GO:0000151	ubiquitin ligase complex	cellular component	IDA[12150907]
GO:0030544	Hsp70 protein binding	molecular function	IPI[12150907]
GO:0005789	endoplasmic reticulum membrane	cellular component	IEA
GO:0031072	heat shock protein binding	molecular function	IPI[12150907]
GO:0042416	dopamine biosynthetic process	biological process	IEA

GPR37 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa05012	parkinsons disease	Parkinson's disease	Parkinson's disease (PD) is a progressive neurodegenerative ...... Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic neurons in the substantia nigra. Mutations in alpha-synuclein, UCHL1 (a ubiquitin carboxy-terminal hydrolase L1), parkin, DJ1 (a parkin-associated protein involved with oxidative stress), and PINK1 (a putative serine threonine kinase) are known to cause early-onset PD. Mutations or altered expression of these proteins contributes to PD pathogenesis through common mechanisms that result in proteasome dysfunction, mitochondrial impairment, and oxidative stress. Point mutations in alpha-synuclein and the recently described Iowan functional duplication of alpha-synuclein lead to excessive intracellular accumulation and protofibril formation. Decrease in the amount of soluble alpha-synuclein tends to increase free cytoplasmic dopamine and the formation of reactive oxygen species (ROS). Indeed, formation of protofibrils or aggregates and Lewy bodies (LBs) diminishes the availability of the physiological forms of alpha-synuclein, favoring an increase in TH (tyrosine hydroxylase) and DAT (dopamine transporter), but diminishes vesicles formation and neuronal plasticity. Modification of parkin and UCHL1 are associated with the ubiquitin-proteasome system pathway and may increase proteotoxic stress. Mutations in parkin, DJ1, and PINK1 may alter mitochondiral activity, potentially impairing proteasomal function. Environmental toxins such as N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and rotenone can cause mitochondrial dysfunction and oxidative stress. More...

GPR37 related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
PARKIN_PATHWAY	parkin pathway	Role of Parkin in the Ubiquitin-Proteasomal Pathway	The motor defects of Parkinson's disease are related to the ...... The motor defects of Parkinson's disease are related to the loss of dopaminergic neurons in specific brain regions. Examination of these neurons in diseased tissue has revealed the presence of Lewy bodies, dense aggregates that include the protein alpha-synuclein. A genetic basis for most cases of Parkinson's disease has not yet been identified, but mutations in alpha-synuclein have been associated with at least one rare form of the disease, and mutations in another protein, the parkin gene, are associated with another inherited form of Parkinson's disease. Parkin is found in Lewy bodies along with alpha-synuclein and the parkin protein is an E3 ubiquitin ligase. Parkin appears to work in conjuction with ubiquitin activating (Uba)1, an E1 protein and the ubiquitin-conjugating (Ubc) enzymes UbcH7 and 8. The E1 delivers ubiquitin to the E2 in a cycle that creates an increasing chain of ubiquitin. The Parkin E3 ligates this onto substrates and so tags these proteins in normal cells, targeting them for destruction in the proteosome. One of the proteins that parkin normally targets for destruction is a specific O-glycosylated form of alpha-synuclein. Failure of parkin-mediated degradation of alpha-synuclein may be a key factor leading to the death of dopaminergic neurons. Another substrate of parkin is a GPCR-like protein called Pael-R that accumulates in the ER of affected cells and may cause neuronal cell death. The involvement of Parkin and alpha-synuclein mutations in genetic forms of Parkinson's suggest that failure of ubiquitination and protein degradation may be causative in other forms of Parkinson's. Questions remaining include the cause of the lack of effective ubiquitination in individuals lacking obvious genetic defects in this pathway and how to use this knowledge of ubiquitination and protein degradation in Parkinson's disease to identify therapeutic strategies. More...

GPR37 related Reactome pathways (count: 0)

GPR37 related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
GPR37	STUB1	No	in vitro	12150907
GPR37	PARK2	No	in vitro;in vivo	12150907 , 11439185

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped BioCarta pathways