Gene Report

Basic Information

Approved Symbol	EFS
Approved Name	embryonal Fyn-associated substrate
Symbol Alias	EFS2, EFS1, HEFS, SIN, CASS3
Name Alias	"Cas scaffolding protein family member 3"
Location	14q11.2-q12
Position	chr14:23834235-23834423 (-)
External Links	Entrez Gene: 10278 Ensembl: ENSG00000100842 UCSC: uc001wjo.4 HGNC ID: 16898
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between EFS and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
EFS2	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between EFS and other components at different levels (count: 0)

Positive relationship network of EFS in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between EFS and MDD (count: 0)

Negative relationships between EFS and other components at different levels (count: 0)

EFS related SNPs in MK4MDD (count: 0)

EFS related proteins in MK4MDD (count: 0)

EFS related GO terms (count: 6)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0017124	SH3 domain binding	molecular function	IEA
GO:0005737	cytoplasm	cellular component	TAS[9349509]
GO:0005515	protein binding	molecular function	IPI[25416956]
GO:0007155	cell adhesion	biological process	IEA
GO:0035556	intracellular signal transduction	biological process	TAS[9349509]
GO:0019904	protein domain specific binding	molecular function	IPI[11984006]

EFS related KEGG pathways (count: 0)

EFS related BioCarta pathways (count: 0)

EFS related Reactome pathways (count: 0)

EFS related interactors from protein-protein interaction data in HPRD (count: 7)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
EFS	SH2D3C	No	yeast 2-hybrid	16189514
EFS	SORBS3	No	yeast 2-hybrid	16189514
EFS	BCAR1	No	yeast 2-hybrid	16169070
EFS	PTPN12	No	in vitro	9748319
EFS	TRAPPC6A	No	yeast 2-hybrid	16189514
EFS	PTK2B	Yes	in vitro	9750131
EFS	PTK2	No	in vitro	9750131

Gene Report

Gene mapped GO terms