Gene Report

Basic Information

Approved Symbol	MAL
Approved Name	mal, T-cell differentiation protein
Location	2q11.1
Position	chr2:95691400-95719737 (+)
External Links	Entrez Gene: 4118 Ensembl: ENSG00000172005 UCSC: uc002stx.1 HGNC ID: 6817
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between MAL and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
MAL	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between MAL and other components at different levels (count: 0)

Positive relationship network of MAL in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between MAL and MDD (count: 0)

Negative relationships between MAL and other components at different levels (count: 0)

MAL related SNPs in MK4MDD (count: 0)

MAL related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Myelin and lymphocyte protein	P21145	0(0/0)	Gene mapped

MAL related GO terms (count: 17)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0030154	cell differentiation	biological process	TAS[10739088]
GO:0008289	lipid binding	molecular function	TAS[10739088]
GO:0005768	endosome	cellular component	TAS[9003426]
GO:0045176	apical protein localization	biological process	TAS[10739088]
GO:0005887	integral to plasma membrane	cellular component	TAS[9003426]
GO:0042552	myelination	biological process	NAS[12153479]; TAS[10428054]
GO:0005783	endoplasmic reticulum	cellular component	IDA[8132541]
GO:0019898	extrinsic to membrane	cellular component	IEA
GO:0019911	structural constituent of myelin sheath	molecular function	IDA[12153479]
GO:0016505	apoptotic protease activator activity	molecular function	NAS[10366425]
GO:0006917	induction of apoptosis	biological process	NAS[10366425]
GO:0045121	membrane raft	cellular component	IDA[12153479]
GO:0001766	membrane raft polarization	biological process	TAS[12153479]
GO:0015267	channel activity	molecular function	TAS[3494249]
GO:0007417	central nervous system development	biological process	TAS[10739088]
GO:0005515	protein binding	molecular function	IPI
GO:0016324	apical plasma membrane	cellular component	TAS[10739088]

MAL related KEGG pathways (count: 0)

MAL related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
MAL_PATHWAY	mal pathway	Role of MAL in Rho-Mediated Activation of SRF	Serum response factor (SRF) is a transcription factor, which...... Serum response factor (SRF) is a transcription factor, which binds to a serum response element (SRE) associated with a variety of genes including (i)immediate early genes such as c-fos, fosB, junB, egr-1 and -2, (ii)neuronal genes such as nurr1 and nur77, and (iii)muscle genes such as actins and myosins. By regulating expression of these genes, SRF controls cell growth and differentiation, neuronal transmission as well as muscle development and function. SRF can be activated by serum, lysophosphatidic acid (LPA), lipopolysaccharide (LPS), 12-O-tetradecanoylphorbol-13-acetate (TPA), cytokines, tumor necrosis factor-alpha (TNFalpha), agents that increase intracellular Ca2+, T-cell virus1 activator protein, hepatitis B virus activator proteins pX, activated oncogenes and protooncogenes and extracellular stimuli such as antioxidant and UV light. In serum-starved cells, MAL is predominantly cytoplasmic where it is sequestered by actin monomers. Upon serum stimulation, Rho becomes active and, through its interaction with ROCK and mDia1, causes an accumulation of F-actin and a commensurate decrease in the level of G-actin. As a consequence, MAL is no longer sequestered and is free to translocate to the nucleus where it associates with SRF and activates SRE-mediated gene expression. More...

MAL related Reactome pathways (count: 0)

MAL related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Gene mapped GO terms

Gene mapped BioCarta pathways