Gene Report

Basic Information

Approved Symbol	DYNC1LI2
Approved Name	dynein, cytoplasmic 1, light intermediate chain 2
Previous Symbol	DNCLI2
Previous Name	dynein, cytoplasmic, light intermediate polypeptide 2
Location	16q22.1
Position	chr16:66754799-66785525 (-)
External Links	Entrez Gene: 1783 Ensembl: ENSG00000135720 UCSC: uc002eqb.1 HGNC ID: 2966
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between DYNC1LI2 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
DNCLI2	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between DYNC1LI2 and other components at different levels (count: 0)

Positive relationship network of DYNC1LI2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between DYNC1LI2 and MDD (count: 0)

Negative relationships between DYNC1LI2 and other components at different levels (count: 0)

DYNC1LI2 related SNPs in MK4MDD (count: 0)

DYNC1LI2 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Cytoplasmic dynein 1 light intermediate chain 2	O43237	0(0/0)	Gene mapped

DYNC1LI2 related GO terms (count: 11)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0032553	ribonucleotide binding	molecular function	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0000226	microtubule cytoskeleton organization	biological process	IEA
GO:0003774	motor activity	molecular function	IEA
GO:0006810	transport	biological process	IEA
GO:0051642	centrosome localization	biological process	IEA
GO:0005813	centrosome	cellular component	IDA
GO:0005829	cytosol	cellular component	TAS
GO:0005524	ATP binding	molecular function	IEA
GO:0005874	microtubule	cellular component	IEA
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	biological process	TAS
GO:0005868	cytoplasmic dynein complex	cellular component	TAS[7738094]

DYNC1LI2 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04962	vasopressin regulated_water_reabsorption	Vasopressin-regulated water reabsorption	In the kidney, the antidiuretic hormone vasopressin (AVP) is...... In the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adjusting the urinary water excretion. In normal physiology, AVP is secreted into the circulation by the posterior pituitary gland, in response to an increase in serum osmolality or a decrease in effective circulating volume. When reaching the kidney, AVP binds to V2 receptors on the basolateral surface of the collecting duct epithelium, triggering a G-protein-linked signaling cascade, which leads to water channel aquaporin-2 (AQP2) vesicle insertion into the apical plasma membrane. This results in higher water permeability in the collecting duct and, driven by an osmotic gradient, pro-urinary water then passes the membrane through AQP2 and leaves the cell on the basolateral side via AQP3 and AQP4 water channels, which are constitutively expressed on the basolateral side of these cells. When isotonicity is restored, reduced blood AVP levels results in AQP2 internalization, leaving the apical membrane watertight again. More...

DYNC1LI2 related BioCarta pathways (count: 0)

DYNC1LI2 related Reactome pathways (count: 0)

DYNC1LI2 related interactors from protein-protein interaction data in HPRD (count: 1)

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways