Gene Report

Basic Information

Approved Symbol	GPRC5B
Approved Name	G protein-coupled receptor, class C, group 5, member B
Previous Name	"G protein-coupled receptor, family C, group 1, member B", "G protein-coupled receptor, family C, group 5, member B"
Symbol Alias	RAIG-2
Location	16p12
Position	chr16:19896917-19897049 (-)
External Links	Entrez Gene: 51704 Ensembl: ENSG00000167191 UCSC: uc002dgt.3 HGNC ID: 13308
No. of Studies (Positive/Negative)	3(3/0)
Type	Literature-origin

Positive relationships between GPRC5B and MDD (count: 3)

Name in Literature	Reference	Research Type	Relation Description
GPRC5B	Aston, 2005	patients and normal controls	Genes altered in major depressive disorder Genes altered in major depressive disorder
GPRC5B	Chu TT, 2009	Patients and nomal controls	Down regulation, fold change([MD] vs [C]) 2.0028336 Down regulation, fold change([MD] vs [C]) 2.0028336
GPRC5B	Tomita H, 2013	patients and normal controls	GPLS genes significantly dysregulated in anterior cingulate ...... GPLS genes significantly dysregulated in anterior cingulate cortex by microarray More...

Positive relationships between GPRC5B and other components at different levels (count: 0)

Positive relationship network of GPRC5B in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between GPRC5B and MDD (count: 0)

Negative relationships between GPRC5B and other components at different levels (count: 0)

GPRC5B related SNPs in MK4MDD (count: 0)

GPRC5B related proteins in MK4MDD (count: 0)

GPRC5B related GO terms (count: 24)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0019901	protein kinase binding	molecular function	ISS
GO:0043231	intracellular membrane-bounded organelle	cellular component	IDA
GO:0005730	nucleolus	cellular component	IDA
GO:0005634	nucleus	cellular component	IDA
GO:0030295	protein kinase activator activity	molecular function	IDA[23169819]
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	biological process	ISS
GO:0032147	activation of protein kinase activity	biological process	IDA[23169819]
GO:0061098	positive regulation of protein tyrosine kinase activity	biological process	ISS
GO:0016021	integral component of membrane	cellular component	IEA
GO:0005886	plasma membrane	cellular component	IEA
GO:0007626	locomotory behavior	biological process	IEA
GO:0060907	positive regulation of macrophage cytokine production	biological process	ISS
GO:0045666	positive regulation of neuron differentiation	biological process	ISS
GO:0010976	positive regulation of neuron projection development	biological process	IEA
GO:0030659	cytoplasmic vesicle membrane	cellular component	IEA
GO:0090263	positive regulation of canonical Wnt signaling pathway	biological process	ISS
GO:0001664	G-protein coupled receptor binding	molecular function	ISS
GO:0005615	extracellular space	cellular component	IDA[16502470]
GO:0042593	glucose homeostasis	biological process	IEA
GO:0050729	positive regulation of inflammatory response	biological process	ISS
GO:0009986	cell surface	cellular component	ISS
GO:0070062	extracellular exosome	cellular component	IDA[19056867\|21557262\|23376485\|23533145]
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IEA
GO:0004930	G-protein coupled receptor activity	molecular function	IEA

GPRC5B related KEGG pathways (count: 0)

GPRC5B related BioCarta pathways (count: 0)

GPRC5B related Reactome pathways (count: 0)

GPRC5B related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Gene mapped GO terms