Gene Report

Basic Information

Approved Symbol	CDKN1C
Approved Name	cyclin-dependent kinase inhibitor 1C (p57, Kip2)
Previous Symbol	BWCR, BWS
Previous Name	Beckwith-Wiedemann syndrome
Symbol Alias	P57, KIP2
Location	11p15.5
Position	chr11:2904448-2906995 (-)
External Links	Entrez Gene: 1028 Ensembl: ENSG00000129757 UCSC: uc001lws.4 HGNC ID: 1786
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between CDKN1C and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CDKN1C	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between CDKN1C and other components at different levels (count: 0)

Positive relationship network of CDKN1C in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CDKN1C and MDD (count: 0)

Negative relationships between CDKN1C and other components at different levels (count: 0)

CDKN1C related SNPs in MK4MDD (count: 0)

CDKN1C related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Cyclin-dependent kinase inhibitor 1C	P49918	0(0/0)	Gene mapped

CDKN1C related GO terms (count: 18)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005634	nucleus	cellular component	IDA
GO:0000080	G1 phase of mitotic cell cycle	biological process	TAS[7729684]
GO:0005730	nucleolus	cellular component	IDA
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	biological process	IMP[16943770]
GO:0007050	cell cycle arrest	biological process	IEA
GO:0042326	negative regulation of phosphorylation	biological process	IDA[19170105]
GO:0004861	cyclin-dependent protein kinase inhibitor activity	molecular function	IEA
GO:0008285	negative regulation of cell proliferation	biological process	TAS[7729684]
GO:0005737	cytoplasm	cellular component	IDA
GO:0042551	neuron maturation	biological process	IEA
GO:0050680	negative regulation of epithelial cell proliferation	biological process	IMP[16943770]
GO:0045893	positive regulation of transcription, DNA-dependent	biological process	IGI[19170105]
GO:0001890	placenta development	biological process	IEA
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IEA
GO:0005515	protein binding	molecular function	IPI
GO:0000079	regulation of cyclin-dependent protein kinase activity	biological process	TAS[7729684]
GO:0045892	negative regulation of transcription, DNA-dependent	biological process	IDA[19170105]
GO:0033673	negative regulation of kinase activity	biological process	IDA[19170105]

CDKN1C related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04110	cell cycle	Cell cycle	Mitotic cell cycle progression is accomplished through a rep...... Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated. Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation. More...

CDKN1C related BioCarta pathways (count: 0)

CDKN1C related Reactome pathways (count: 0)

CDKN1C related interactors from protein-protein interaction data in HPRD (count: 8)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
CDKN1C	LIMK1	No	in vitro;in vivo;yeast 2-hybrid	14530263
CDKN1C	MYOD1	No	in vitro;in vivo	10764802
CDKN1C	SKP2	No	in vitro;in vivo	12925736
CDKN1C	FBXL12	No	in vivo	18660753
CDKN1C	PCNA	No	in vitro;in vivo	9465025
CDKN1C	CDK4	No	in vivo	9106657
CDKN1C	NR4A2	Yes	in vitro	14671317
CDKN1C	CCNE2	No	yeast 2-hybrid	9840943

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways