Gene Report

Basic Information

Approved Symbol	DDX23
Approved Name	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
Previous Name	PRP28 homolog, yeast
Symbol Alias	prp28, U5-100K, PRPF28
Location	12q13.11
Position	chr12:49223539-49245957 (-)
External Links	Entrez Gene: 9416 Ensembl: ENSG00000174243 UCSC: uc001rsm.3 HGNC ID: 17347
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between DDX23 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
U5-100K	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between DDX23 and other components at different levels (count: 0)

Positive relationship network of DDX23 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between DDX23 and MDD (count: 0)

Negative relationships between DDX23 and other components at different levels (count: 0)

DDX23 related SNPs in MK4MDD (count: 0)

DDX23 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Probable ATP-dependent RNA helicase DDX23	Q9BUQ8	0(0/0)	Gene mapped

DDX23 related GO terms (count: 18)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0032553	ribonucleotide binding	molecular function	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0071013	catalytic step 2 spliceosome	cellular component	IDA[11991638]
GO:0000398	mRNA splicing, via spliceosome	biological process	IC[11991638]; TAS
GO:0000354	cis assembly of pre-catalytic spliceosome	biological process	IC[9539711]
GO:0005886	plasma membrane	cellular component	IDA
GO:0000375	RNA splicing, via transesterification reactions	biological process	TAS[9409622]
GO:0005730	nucleolus	cellular component	IDA
GO:0005739	mitochondrion	cellular component	IDA
GO:0005654	nucleoplasm	cellular component	TAS
GO:0004004	ATP-dependent RNA helicase activity	molecular function	TAS[9409622]
GO:0010467	gene expression	biological process	TAS
GO:0008026	ATP-dependent helicase activity	molecular function	IDA[9539711]
GO:0005515	protein binding	molecular function	IPI
GO:0005634	nucleus	cellular component	IDA
GO:0005682	U5 snRNP	cellular component	IDA[9539711]
GO:0008380	RNA splicing	biological process	TAS
GO:0003676	nucleic acid binding	molecular function	IEA
GO:0005524	ATP binding	molecular function	IEA

DDX23 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa03040	spliceosome	Spliceosome	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...

DDX23 related BioCarta pathways (count: 0)

DDX23 related Reactome pathways (count: 6)

ID	Name	Description
Gene mapped Reactome pathways
REACT_71	gene expression	Gene Expression covers the process of transcription of mRNA ...... Gene Expression covers the process of transcription of mRNA genes, the processing of pre-mRNA, and its subsequent translation to result in a protein. The expression of non-protein-coding genes is not included in this section yet. However, the transcription of RNAs other than mRNA is described in the section on transcription; in the sections 'RNA Polymerase I Transcription', and 'RNA Polymerase III Transcription'. More...
REACT_1753	mrna splicing_minor_pathway	The splicing of a subset of pre-mRNA introns occurs by a sec...... The splicing of a subset of pre-mRNA introns occurs by a second pathway, designated the AT-AC or U12-dependent splicing pathway. AT-AC introns have highly conserved, non-canonical splice sites that are removed by the AT-AC spliceosome, which contains distinct snRNAs (U11, U12, U4atac, U6atac) that are structurally and functionally analogous to the major spliceosome. U5 snRNA as well as many of the protein factors appear to be conserved between the two spliceosomes. More...
REACT_1021	elongation and_processing_of_capped_transcripts
REACT_125	processing of_capped_intron_containing_pre_mrna	Any covalent change in a primary (nascent) mRNA transcript i...... Any covalent change in a primary (nascent) mRNA transcript is mRNA Processing. For successful gene expression, the primary mRNA transcript needs to be converted to a mature mRNA prior to its translation into polypeptide. Eucaryotic mRNAs undergo a series of complex processing reactions; these begin on nascent transcripts as soon as a few ribonucleotides have been synthesized during transcription by RNA Polymerase II, through the export of the mature mRNA to the cytoplasm, and culminate with mRNA turnover in the cytoplasm. More...
REACT_1735	mrna splicing	The process in which excision of introns from the primary tr...... The process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, is called mRNA splicing. Most of the mRNA is spliced by the major pathway, involving the U1, U2, U4, U5 and U6 snRNPs. A minor fraction, about 1 %, of the mRNAs are spliced via the U12 dependent pathway. More...
REACT_2039	formation and_maturation_of_mrna_transcript	Before a gene transcript is ready to be transported out of t...... Before a gene transcript is ready to be transported out of the nucleus, it has to undergo three major processing events to produce a fully translatable mRNA. These comprise capping, splicing out of introns from within the body of the pre-mRNA, and the generation of a 3' end, by cleavage, and except in the case of histone pre-mRNAs, polyadenylation. Although each of these reactions is a biochemically distinct process, these processes are interlinked and hence, influence one another's specificity and efficiency. On the other hand, most mRNA processing reactions occur co-transcriptionally. This is particularly important in very long genes where a strictly post-transcriptional processing would imply the existence of extremely long primary transcript molecules that would be susceptible to degradation. The co-transcriptional nature of pre-mRNA processing does not necessarily imply a functional coupling between the transcription and mRNA processing machineries. In some cases it may simply reflect that processing reactions occur during transcription because they are relatively fast compared with the time it takes to transcribe a gene to its end. In other cases a tight link exists between a particular processing reaction and the transcription process, due to the ability of the carboxy-terminal (CTD) of RNA polymerase II largest subunit to bind or recruit processing factors. The CTD consists of 52 heptad repeats (YSPTSPS). Specific phosphorylation/dephosphorylation patterns of serines 2 and 5 are critical for CTD function in coupling. CTD deletions that do not inactivate transcription significantly decrease the efficiency of capping, splicing and polyadenylation. The export of mRNA from the nucleus and mRNA splicing are also coupled. Mature mRNAs generated by splicing are more efficiently exported than their identical counterparts transcribed from a complementary DNA (cDNA). This effect of splicing on export is due to the recruitment of the mRNA export factor ALY to the mRNA during the splicing reaction, which in turn delivers the mRNP to the nuclear pore for export. More...

DDX23 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways