Gene Report

Basic Information

Approved Symbol	PLAGL1
Approved Name	pleiomorphic adenoma gene-like 1
Symbol Alias	ZAC, LOT1
Location	6q24-q25
Position	chr6:144261437-144385735 (-)
External Links	Entrez Gene: 5325 Ensembl: ENSG00000118495 UCSC: uc003qkf.3 HGNC ID: 9046
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between PLAGL1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
PLAGL1	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between PLAGL1 and other components at different levels (count: 0)

Positive relationship network of PLAGL1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between PLAGL1 and MDD (count: 0)

Negative relationships between PLAGL1 and other components at different levels (count: 0)

PLAGL1 related SNPs in MK4MDD (count: 0)

PLAGL1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Zinc finger protein PLAGL1	Q9UM63	0(0/0)	Gene mapped

PLAGL1 related GO terms (count: 7)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0008270	zinc ion binding	molecular function	IEA
GO:0005634	nucleus	cellular component	IEA
GO:0006917	induction of apoptosis	biological process	TAS[9671765]
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[15888726]
GO:0006351	transcription, DNA-dependent	biological process	IEA
GO:0003677	DNA binding	molecular function	IDA[15888725]
GO:0007050	cell cycle arrest	biological process	TAS[9184226]

PLAGL1 related KEGG pathways (count: 0)

PLAGL1 related BioCarta pathways (count: 0)

PLAGL1 related Reactome pathways (count: 0)

PLAGL1 related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
PLAGL1	SMAD3	No	yeast 2-hybrid	15231748
PLAGL1	PLAGL1	Yes	in vivo	12529403
PLAGL1	TP53	No	in vitro	11360197

Gene Report

Gene mapped GO terms