Gene Report

Basic Information

Approved Symbol	SEMA3C
Approved Name	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
Previous Symbol	SEMAE
Symbol Alias	SemE
Location	7q21-q31
Position	chr7:80551597-80551695 (-)
External Links	Entrez Gene: 10512 Ensembl: ENSG00000075223 UCSC: uc003uhj.3 HGNC ID: 10725
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin

Positive relationships between SEMA3C and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
SEMAE	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder
SEMA3C	Mostafavi S, 2013	patients and normal controls	P-value=2.52E-04

Positive relationships between SEMA3C and other components at different levels (count: 0)

Positive relationship network of SEMA3C in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SEMA3C and MDD (count: 0)

Negative relationships between SEMA3C and other components at different levels (count: 0)

SEMA3C related SNPs in MK4MDD (count: 0)

SEMA3C related proteins in MK4MDD (count: 0)

SEMA3C related GO terms (count: 22)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0050919	negative chemotaxis	biological process	IBA
GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching	biological process	IEA
GO:0001756	somitogenesis	biological process	IEA
GO:0007411	axon guidance	biological process	ISS
GO:0005615	extracellular space	cellular component	IBA
GO:0060174	limb bud formation	biological process	IEA
GO:0042493	response to drug	biological process	TAS[9405678]
GO:0006955	immune response	biological process	TAS[9168980]
GO:0070062	extracellular exosome	cellular component	IDA[23533145]
GO:0001974	blood vessel remodeling	biological process	IEA
GO:0003350	pulmonary myocardium development	biological process	IEA
GO:0009791	post-embryonic development	biological process	IEA
GO:0030215	semaphorin receptor binding	molecular function	IBA
GO:0045499	chemorepellent activity	molecular function	IBA
GO:0003151	outflow tract morphogenesis	biological process	IEA
GO:0003215	cardiac right ventricle morphogenesis	biological process	IEA
GO:0071526	semaphorin-plexin signaling pathway	biological process	IBA
GO:0001755	neural crest cell migration	biological process	IBA
GO:0030335	positive regulation of cell migration	biological process	IBA
GO:0048843	negative regulation of axon extension involved in axon guidance	biological process	IBA
GO:0021915	neural tube development	biological process	IEA
GO:0038191	neuropilin binding	molecular function	IBA

SEMA3C related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Literature-origin KEGG pathway
hsa04360	axon guidance	Axon guidance	Axon guidance represents a key stage in the formation of neu...... Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn. More...

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways

SEMA3C related BioCarta pathways (count: 0)

SEMA3C related Reactome pathways (count: 0)

SEMA3C related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
SEMA3C	NRP1	Yes	in vivo	9331348
SEMA3C	NRP2	No	in vivo	9331348

Gene Report

Gene mapped GO terms

Literature-origin KEGG pathway

Gene mapped KEGG pathways