Gene Report

Basic Information

Approved Symbol	UGT8
Approved Name	UDP glycosyltransferase 8
Previous Symbol	CGT
Previous Name	UDP-galactose ceramide galactosyltransferase
Name Alias	2-hydroxyacylsphingosine 1-beta-galactosyltransferase
Location	4q26
Position	chr4:115519611-115598202 (+)
External Links	Entrez Gene: 7368 Ensembl: ENSG00000174607 UCSC: uc003ibs.2 HGNC ID: 12555
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between UGT8 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
UGT8	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between UGT8 and other components at different levels (count: 0)

Positive relationship network of UGT8 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between UGT8 and MDD (count: 0)

Negative relationships between UGT8 and other components at different levels (count: 0)

UGT8 related SNPs in MK4MDD (count: 0)

UGT8 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
2-hydroxyacylsphingosine 1-beta-galactosyltransferase	Q16880	0(0/0)	Gene mapped

UGT8 related GO terms (count: 11)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0007422	peripheral nervous system development	biological process	TAS[8661025]
GO:0006682	galactosylceramide biosynthetic process	biological process	IEA
GO:0008489	UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity	molecular function	IEA
GO:0002175	protein localization to paranode region of axon	biological process	IEA
GO:0007010	cytoskeleton organization	biological process	IEA
GO:0016021	integral to membrane	cellular component	IEA
GO:0003851	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity	molecular function	IEA
GO:0008088	axon cargo transport	biological process	IEA
GO:0048812	neuron projection morphogenesis	biological process	IEA
GO:0030913	paranodal junction assembly	biological process	IEA
GO:0007417	central nervous system development	biological process	TAS[8661025]

UGT8 related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa00600	sphingolipid metabolism	Sphingolipid metabolism

UGT8 related BioCarta pathways (count: 0)

UGT8 related Reactome pathways (count: 0)

UGT8 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways