Gene Report

Basic Information

Approved Symbol	SOX10
Approved Name	SRY (sex determining region Y)-box 10
Symbol Alias	DOM, WS4, WS2E
Name Alias	dominant megacolon, mouse, human homolog of
Location	22q13.1
Position	chr22:38368319-38380539 (-)
External Links	Entrez Gene: 6663 Ensembl: ENSG00000100146 UCSC: uc003aun.1 HGNC ID: 11190
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between SOX10 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
SOX10	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between SOX10 and other components at different levels (count: 0)

Positive relationship network of SOX10 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SOX10 and MDD (count: 0)

Negative relationships between SOX10 and other components at different levels (count: 0)

SOX10 related SNPs in MK4MDD (count: 0)

SOX10 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Transcription factor SOX-10	P56693	0(0/0)	Gene mapped

SOX10 related GO terms (count: 28)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0007422	peripheral nervous system development	biological process	IEA
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	molecular function	IEA
GO:0005515	protein binding	molecular function	IPI[16214168]
GO:0006357	regulation of transcription from RNA polymerase II promoter	biological process	TAS[9722528]
GO:0042802	identical protein binding	molecular function	IPI[11029584]
GO:0003713	transcription coactivator activity	molecular function	TAS[9722528]
GO:0048546	digestive tract morphogenesis	biological process	IEA
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	molecular function	IEA
GO:0045892	negative regulation of transcription, DNA-dependent	biological process	IEA
GO:0048484	enteric nervous system development	biological process	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IEA
GO:0048863	stem cell differentiation	biological process	IEA
GO:0001755	neural crest cell migration	biological process	IEA
GO:0048589	developmental growth	biological process	IEA
GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	biological process	IEA
GO:0008134	transcription factor binding	molecular function	IEA
GO:0043066	negative regulation of apoptotic process	biological process	IEA
GO:0009653	anatomical structure morphogenesis	biological process	TAS[9425902]
GO:0014015	positive regulation of gliogenesis	biological process	IEA
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	molecular function	IEA
GO:0048469	cell maturation	biological process	IEA
GO:0003682	chromatin binding	molecular function	IEA
GO:0030318	melanocyte differentiation	biological process	IEA
GO:0031315	extrinsic to mitochondrial outer membrane	cellular component	IEA
GO:0048709	oligodendrocyte differentiation	biological process	IEA
GO:0002052	positive regulation of neuroblast proliferation	biological process	IEA
GO:0005634	nucleus	cellular component	IDA[18512230]; ISS
GO:0001701	in utero embryonic development	biological process	IEA

SOX10 related KEGG pathways (count: 0)

SOX10 related BioCarta pathways (count: 0)

SOX10 related Reactome pathways (count: 0)

SOX10 related interactors from protein-protein interaction data in HPRD (count: 27)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
SOX10	POU3F3	No	in vitro;yeast 2-hybrid	16582099
SOX10	HHEX	No	in vitro;yeast 2-hybrid	16582099
SOX10	MEOX1	No	yeast 2-hybrid	16582099
SOX10	SOX10	Yes	in vitro;yeast 2-hybrid	11029584
SOX10	ALX4	No	yeast 2-hybrid	16582099
SOX10	UTF1	No	in vitro;yeast 2-hybrid	16582099
SOX10	DLX5	No	in vitro;yeast 2-hybrid	16582099
SOX10	JUN	Yes	in vitro	16582099
SOX10	PRRX1	No	yeast 2-hybrid	16582099
SOX10	HIVEP1	No	yeast 2-hybrid	16582099
SOX10	SUMO1	No	in vivo	16494873
SOX10	NMI	No	in vivo;yeast 2-hybrid	16214168
SOX10	PAX6	No	yeast 2-hybrid	16582099
SOX10	SP1	No	in vitro	16582099
SOX10	POU5F1	No	in vitro	16582099
SOX10	PAX3	No	in vitro;in vivo	10942418 , 12668617
SOX10	UBE2I	No	in vivo	16494873
SOX10	CEBPA	No	in vitro	16582099
SOX10	OLIG2	Yes	in vitro	16582099
SOX10	TCF12	No	in vitro	16582099
SOX10	EGR2	No	in vitro	16582099
SOX10	PRRX2	No	yeast 2-hybrid	16582099
SOX10	SUMO2	No	in vivo	16494873
SOX10	SUMO3	No	in vivo	16494873
SOX10	HOXC4	No	yeast 2-hybrid	16582099
SOX10	HOXA3	No	yeast 2-hybrid	16582099
SOX10	POU3F2	No	in vitro;yeast 2-hybrid	11029584

Gene Report

Gene mapped GO terms