Gene Report

Basic Information

Approved Symbol	SRSF10
Approved Name	serine/arginine-rich splicing factor 10
Previous Symbol	FUSIP2, FUSIP1, SFRS13A
Previous Name	FUS-interacting protein (serine-arginine rich) 2, "FUS interacting protein (serine/arginine-rich) 1", "splicing factor, arginine/serine-rich 13A", "neural-salient SR protein"
Symbol Alias	TASR1, TASR2, SRp38, SRrp40, SFRS13, NSSR
Name Alias	splicing factor, arginine/serine-rich 13, "SR splicing factor 10"
Location	1p36.11
Position	chr1:24292935-24306953 (-)
External Links	Entrez Gene: 10772 Ensembl: ENSG00000188529 UCSC: uc021oir.1 HGNC ID: 16713
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between SRSF10 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
TASR	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between SRSF10 and other components at different levels (count: 0)

Positive relationship network of SRSF10 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SRSF10 and MDD (count: 0)

Negative relationships between SRSF10 and other components at different levels (count: 0)

SRSF10 related SNPs in MK4MDD (count: 0)

SRSF10 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Serine/arginine-rich splicing factor 10	O75494	0(0/0)	Gene mapped

SRSF10 related GO terms (count: 17)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0000166	nucleotide binding	molecular function	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0006376	mRNA splice site selection	biological process	IDA[9774382]
GO:0048025	negative regulation of mRNA splicing, via spliceosome	biological process	IDA[11684676]
GO:0005634	nucleus	cellular component	IC[9774382]
GO:0006406	mRNA export from nucleus	biological process	NAS[11684676]
GO:0050733	RS domain binding	molecular function	NAS[11684676]
GO:0000375	RNA splicing, via transesterification reactions	biological process	IDA[9774382]
GO:0005737	cytoplasm	cellular component	NAS[11684676]
GO:0005654	nucleoplasm	cellular component	IDA[11684676]
GO:0051082	unfolded protein binding	molecular function	NAS[11684676]
GO:0016482	cytoplasmic transport	biological process	IDA[11684676]
GO:0000398	mRNA splicing, via spliceosome	biological process	IDA[9774382]
GO:0003723	RNA binding	molecular function	NAS[9774382]
GO:0016607	nuclear speck	cellular component	IEA
GO:0005515	protein binding	molecular function	IPI[9774382]
GO:0006355	regulation of transcription, DNA-dependent	biological process	NAS[9774382]
GO:0000244	assembly of spliceosomal tri-snRNP	biological process	NAS[11684676]

SRSF10 related KEGG pathways (count: 0)

SRSF10 related BioCarta pathways (count: 0)

SRSF10 related Reactome pathways (count: 0)

SRSF10 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Literature-origin GO terms

Gene mapped GO terms