Gene Report

Basic Information

Approved Symbol	SPOCK1
Approved Name	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
Previous Symbol	TIC1, SPOCK
Previous Name	"sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican)"
Symbol Alias	testican-1
Location	5q31.2
Position	chr5:136834868-136835017 (-)
External Links	Entrez Gene: 6695 Ensembl: ENSG00000152377 UCSC: uc003lbp.3 HGNC ID: 11251
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between SPOCK1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
SPOCK	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between SPOCK1 and other components at different levels (count: 0)

Positive relationship network of SPOCK1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SPOCK1 and MDD (count: 0)

Negative relationships between SPOCK1 and other components at different levels (count: 0)

SPOCK1 related SNPs in MK4MDD (count: 0)

SPOCK1 related proteins in MK4MDD (count: 0)

SPOCK1 related GO terms (count: 21)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0022008	neurogenesis	biological process	ISS
GO:0014069	postsynaptic density	cellular component	NAS[9181134]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0010812	negative regulation of cell-substrate adhesion	biological process	IDA[12853036]
GO:0005615	extracellular space	cellular component	IDA[14511383]
GO:0033268	node of Ranvier	cellular component	ISS
GO:0007165	signal transduction	biological process	IEA
GO:0004867	serine-type endopeptidase inhibitor activity	molecular function	NAS[14511383]
GO:0004869	cysteine-type endopeptidase inhibitor activity	molecular function	IDA[14511383]
GO:0007399	nervous system development	biological process	NAS[9181134]
GO:0010977	negative regulation of neuron projection development	biological process	IDA[12853036]
GO:0001764	neuron migration	biological process	ISS
GO:0010951	negative regulation of endopeptidase activity	biological process	IDA[14511383]
GO:0031594	neuromuscular junction	cellular component	ISS
GO:0005737	cytoplasm	cellular component	ISS
GO:0001558	regulation of cell growth	biological process	NAS[8389704]
GO:0005578	proteinaceous extracellular matrix	cellular component	IEA
GO:0021953	central nervous system neuron differentiation	biological process	ISS
GO:0007155	cell adhesion	biological process	NAS[8389704]
GO:0005509	calcium ion binding	molecular function	IDA[9323035]
GO:0008191	metalloendopeptidase inhibitor activity	molecular function	IDA[11751414]
GO:0016528	sarcoplasm	cellular component	ISS

SPOCK1 related KEGG pathways (count: 0)

SPOCK1 related BioCarta pathways (count: 0)

SPOCK1 related Reactome pathways (count: 0)

SPOCK1 related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
SPOCK1	MMP2	No	in vitro	12810672
SPOCK1	MMP3	No	in vitro	12810672
SPOCK1	MMP14	Yes	in vitro	12810672

Gene Report

Literature-origin GO terms

Gene mapped GO terms