Gene Report

Basic Information

Approved Symbol	GSTM3
Approved Name	glutathione S-transferase mu 3 (brain)
Previous Name	"glutathione S-transferase M3 (brain)"
Symbol Alias	GST5
Location	1p13.3
Position	chr1:110283575-110283660 (-)
External Links	Entrez Gene: 2947 Ensembl: ENSG00000134202 UCSC: uc001dyo.2 HGNC ID: 4635
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between GSTM3 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
GSTM3	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between GSTM3 and other components at different levels (count: 0)

Positive relationship network of GSTM3 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between GSTM3 and MDD (count: 0)

Negative relationships between GSTM3 and other components at different levels (count: 0)

GSTM3 related SNPs in MK4MDD (count: 0)

GSTM3 related proteins in MK4MDD (count: 0)

GSTM3 related GO terms (count: 19)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0006805	xenobiotic metabolic process	biological process	TAS
GO:0042178	xenobiotic catabolic process	biological process	IDA[8373352]
GO:0005634	nucleus	cellular component	IDA[21630459]
GO:0043295	glutathione binding	molecular function	IDA[8373352]
GO:0043627	response to estrogen	biological process	IEP[10037815]
GO:0006749	glutathione metabolic process	biological process	IDA[8373352\|10587441]
GO:0005829	cytosol	cellular component	TAS
GO:0008065	establishment of blood-nerve barrier	biological process	TAS[2345169]
GO:1901687	glutathione derivative biosynthetic process	biological process	TAS
GO:0005737	cytoplasm	cellular component	IDA[8373352]
GO:0042802	identical protein binding	molecular function	IPI[16189514\|19060904\|21516116]
GO:0018916	nitrobenzene metabolic process	biological process	IDA[8373352]
GO:0019899	enzyme binding	molecular function	IPI[8373352]
GO:0070458	cellular detoxification of nitrogen compound	biological process	IDA[8373352]
GO:0044281	small molecule metabolic process	biological process	TAS
GO:0035686	sperm fibrous sheath	cellular component	IEA
GO:0004364	glutathione transferase activity	molecular function	IDA[8373352\|9545290\|10587441]
GO:0042803	protein homodimerization activity	molecular function	IDA[9545290]; IPI[8373352]
GO:0070062	extracellular exosome	cellular component	IDA[23376485\|23533145]

GSTM3 related KEGG pathways (count: 3)

ID	Name	Brief Description
Gene mapped KEGG pathways
hsa00980	metabolism of_xenobiotics_by_cytochrome_p450	Metabolism of xenobiotics by cytochrome P450
hsa00982	drug metabolism_cytochrome_p450	Drug metabolism - cytochrome P450
hsa00480	glutathione metabolism	Glutathione metabolism

GSTM3 related BioCarta pathways (count: 0)

GSTM3 related Reactome pathways (count: 0)

GSTM3 related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
GSTM3	GSTM2	No	in vitro	1530570
GSTM3	GSTM3	Yes	in vitro;yeast 2-hybrid	1530570 , 16189514

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways