Gene Report

Basic Information

Approved Symbol	FADS1
Approved Name	fatty acid desaturase 1
Previous Symbol	LLCDL1
Symbol Alias	D5D, FADSD5, TU12, FADS6
Name Alias	delta-5 desaturase
Location	11q12-q13.1
Position	chr11:61567097-61584529 (-)
External Links	Entrez Gene: 3992 Ensembl: ENSG00000149485 UCSC: uc010rlm.2 HGNC ID: 3574
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin

Positive relationships between FADS1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
D5D	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between FADS1 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
Fatty acid desaturase (FADS1)		Suicide(suicide attempt)	symptoms	Lalovic, 2010	patients and normal controls		Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosp...... Fatty acid desaturase (FADS1), leptin receptor (LEPR), phosphoinositide-3-kinase (class 2 alpha; PIK3C2A) and stearoyl-CoA desaturase (SCD) were consistently down-regulated in all three regions of the frontal cortex of depressed suicides compared to comparison subjects More...

Positive relationship network of FADS1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between FADS1 and MDD (count: 0)

Negative relationships between FADS1 and other components at different levels (count: 0)

FADS1 related SNPs in MK4MDD (count: 0)

FADS1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Fatty acid desaturase 1	O60427	0(0/0)	Gene mapped

FADS1 related GO terms (count: 28)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0016491	oxidoreductase activity	molecular function	IDA[10601301]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0007267	cell-cell signaling	biological process	NAS[10601301]
GO:0006636	unsaturated fatty acid biosynthetic process	biological process	IDA[10601301]; IEA
GO:0005506	iron ion binding	molecular function	IEA
GO:0044255	cellular lipid metabolic process	biological process	TAS
GO:0044281	small molecule metabolic process	biological process	TAS
GO:0045595	regulation of cell differentiation	biological process	NAS[10601301]
GO:0043231	intracellular membrane-bounded organelle	cellular component	NAS[10601301]
GO:0005789	endoplasmic reticulum membrane	cellular component	TAS
GO:0005634	nucleus	cellular component	IEA
GO:0046456	icosanoid biosynthetic process	biological process	TAS[10601301]
GO:0008654	phospholipid biosynthetic process	biological process	TAS[10601301]
GO:0000248	C-5 sterol desaturase activity	molecular function	TAS[10601301]
GO:0032868	response to insulin stimulus	biological process	IEA
GO:0033559	unsaturated fatty acid metabolic process	biological process	TAS
GO:0043651	linoleic acid metabolic process	biological process	TAS
GO:0016020	membrane	cellular component	NAS[10601301]
GO:0019369	arachidonic acid metabolic process	biological process	IEA
GO:0007568	aging	biological process	IEA
GO:0014070	response to organic cyclic compound	biological process	IEA
GO:0022900	electron transport chain	biological process	IEA
GO:0036109	alpha-linolenic acid metabolic process	biological process	TAS
GO:0009744	response to sucrose stimulus	biological process	IEA
GO:0020037	heme binding	molecular function	IEA
GO:0006355	regulation of transcription, DNA-dependent	biological process	NAS[10601301]
GO:0033189	response to vitamin A	biological process	IEA
GO:0009267	cellular response to starvation	biological process	IDA[10601301]
GO:0016021	integral to membrane	cellular component	NAS[10601301]

FADS1 related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa01040	biosynthesis of_unsaturated_fatty_acids	Biosynthesis of unsaturated fatty acids

FADS1 related BioCarta pathways (count: 0)

FADS1 related Reactome pathways (count: 2)

ID	Name	Description
Gene mapped Reactome pathways
REACT_19241	regulation of_lipid_metabolism_by_peroxisome_proliferator_activated_receptor_alpha	Peroxisome proliferator-activated receptor alpha (PPAR-alpha...... Peroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma lipid levels. PPAR-alpha is a type II nuclear receptor (its subcellular location does not depend on ligand binding). PPAR-alpha forms heterodimers with Retinoid X receptor alpha (RXR-alpha), another type II nuclear receptor. PPAR-alpha is activated by binding fatty acid ligands, especially polyunsaturated fatty acids having 18-22 carbon groups and 2-6 double bonds. The PPAR-alpha:RXR-alpha heterodimer binds peroxisome proliferator receptor elements (PPREs) in and around target genes. Binding of fatty acids and synthetic ligands causes a conformational change in PPAR-alpha such that it releases the corepressors and binds coactivators (CBP-SRC-HAT complex, ASC complex, and TRAP-Mediator complex) which initiate transcription of the target genes. Target genes of PPAR-alpha participate in fatty acid transport, fatty acid oxidation, triglyceride clearance, lipoprotein production, and cholesterol homeostasis. More...
REACT_602	metabolism of_lipids_and_lipoproteins	Lipids are hydrophobic but otherwise chemically diverse mole...... Lipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphingolipids, eicosanoids, cholesterol, bile salts, steroid hormones, and fat-soluble vitamins, and function as a major source of energy (fatty acids, triacylglycerols, and ketone bodies), are major constituents of cell membranes (cholesterol and phospholipids), play a major role in their own digestion and uptake (bile salts), and participate in numerous signaling and regulatory processes (steroid hormones, eicosanoids, and sphingolipids). Because of their poor solubility in water, most lipids in extracellular spaces in the human body are found as complexes with specific carrier proteins. Regulation of the formation and movement of these lipoprotein complexes is a critical aspect of human lipid metabolism, and lipoprotein abnormalities are associated with major human disease processes including atherosclerosis and diabetes. Aspects of lipid metabolism currently annotated in Reactome include lipid digestion, trafficking of dietary sterols, triacylglycerol synthesis (fatty acid synthesis and triacylglycerol assembly), hormone-sensitive lipase-mediated triacylglycerol breakdown, and beta-oxidation of fatty acids, ketone body metabolism (synthesis and utilization), the synthesis of cholesterol, bile salts, and steroid hormones, and sphingolipid metabolism. Three aspects of lipoprotein function are currently annotated: chylomicron-mediated lipid transport, HDL (high density lipoprotein)-mediated lipid transport, and LDL (low density lipoprotein) endocytosis and degradation. More...

FADS1 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways