Gene Report

Basic Information

Approved Symbol	MAN2A1
Approved Name	mannosidase, alpha, class 2A, member 1
Previous Symbol	MANA2
Symbol Alias	GOLIM7
Name Alias	golgi integral membrane protein 7
Location	5
Position	chr5:109025156-109203429 (+)
External Links	Entrez Gene: 4124 Ensembl: ENSG00000112893 UCSC: uc003kou.1 HGNC ID: 6824
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin

Positive relationships between MAN2A1 and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
MAN2A1	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder
MAN2A1	Sequeira A, 2009	patients and nomal controls	Group: P-value=0.016, F=5; Substance: P-value=0.005, F=9.5	Genes differentially expressed after an ANCOVA analysis betw...... Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). More...

Positive relationships between MAN2A1 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
MAN2A1		Suicide(suicide)	symptoms	Sequeira A, 2009	patients and nomal controls	Group: P-value=0.016, F=5; Substance: P-value=0.005, F=9.5	Genes differentially expressed after an ANCOVA analysis betw...... Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). More...

Positive relationship network of MAN2A1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between MAN2A1 and MDD (count: 0)

Negative relationships between MAN2A1 and other components at different levels (count: 0)

MAN2A1 related SNPs in MK4MDD (count: 0)

MAN2A1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Alpha-mannosidase 2	Q16706	0(0/0)	Gene mapped

MAN2A1 related GO terms (count: 17)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0048286	lung alveolus development	biological process	IEA
GO:0001701	in utero embryonic development	biological process	IEA
GO:0008270	zinc ion binding	molecular function	IEA
GO:0007005	mitochondrion organization	biological process	IEA
GO:0007585	respiratory gaseous exchange	biological process	IEA
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	molecular function	IEA
GO:0004572	mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity	molecular function	IEA
GO:0006013	mannose metabolic process	biological process	IEA
GO:0018279	protein N-linked glycosylation via asparagine	biological process	TAS
GO:0001889	liver development	biological process	IEA
GO:0016021	integral to membrane	cellular component	IEA
GO:0043687	post-translational protein modification	biological process	TAS
GO:0006491	N-glycan processing	biological process	IEA
GO:0044267	cellular protein metabolic process	biological process	TAS
GO:0000139	Golgi membrane	cellular component	TAS
GO:0030246	carbohydrate binding	molecular function	IEA
GO:0007033	vacuole organization	biological process	IEA

MAN2A1 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa00510	n glycan_biosynthesis	N-Glycan biosynthesis	N-glycans or asparagine-linked glycans are major constituent...... N-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glycosidic bond, GlcNAc b1- Asn. Biosynthesis of N-glycans begins on the cytoplasmic face of the ER membrane with the transferase reaction of UDP-GlcNAc and the lipid-like precursor P-Dol (dolichol phosphate) to generate GlcNAc a1- PP-Dol. After sequential addition of monosaccharides by ALG glycosyltransferases, the N-glycan precursor is attached by the OST (oligosaccharyltransferase) complex to the polypeptide chain that is being synthesized and translocated through the ER membrane. The protein-bound N-glycan precursor is subsequently trimmed, extended, and modified in the ER and Golgi by a complex series of reactions catalyzed by membrane-bound glycosidases and glycosyltransferases. N-glycans thus synthesized are classified into three types: high-mannose type, complex type, and hybrid type. Defects in N-glycan biosynthesis lead to a variety of human diseases known as congenital disorders of glycosylation. More...

MAN2A1 related BioCarta pathways (count: 0)

MAN2A1 related Reactome pathways (count: 0)

MAN2A1 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways