Gene Report

Basic Information

Approved Symbol	HEXA
Approved Name	hexosaminidase A (alpha polypeptide)
Name Alias	Tay Sachs disease, "GM2 gangliosidosis"
Location	15q24.1
Position	chr15:72635778-72668520 (-)
External Links	Entrez Gene: 3073 Ensembl: ENSG00000213614 UCSC: uc002aun.4 HGNC ID: 4878
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between HEXA and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
HEXA	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between HEXA and other components at different levels (count: 0)

Positive relationship network of HEXA in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between HEXA and MDD (count: 0)

Negative relationships between HEXA and other components at different levels (count: 0)

HEXA related SNPs in MK4MDD (count: 0)

HEXA related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Beta-hexosaminidase subunit alpha	P06865	0(0/0)	Gene mapped

HEXA related GO terms (count: 29)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0048667	cell morphogenesis involved in neuron differentiation	biological process	IEA
GO:0050885	neuromuscular process controlling balance	biological process	IEA
GO:0030214	hyaluronan catabolic process	biological process	TAS
GO:0019953	sexual reproduction	biological process	IEA
GO:0008219	cell death	biological process	IEA
GO:0006665	sphingolipid metabolic process	biological process	TAS
GO:0019915	lipid storage	biological process	IEA
GO:0006644	phospholipid metabolic process	biological process	TAS
GO:0043202	lysosomal lumen	cellular component	TAS
GO:0006689	ganglioside catabolic process	biological process	IEA
GO:0001501	skeletal system development	biological process	IEA
GO:0030204	chondroitin sulfate metabolic process	biological process	TAS
GO:0042340	keratan sulfate catabolic process	biological process	TAS
GO:0005975	carbohydrate metabolic process	biological process	TAS
GO:0030207	chondroitin sulfate catabolic process	biological process	TAS
GO:0043169	cation binding	molecular function	IEA
GO:0030212	hyaluronan metabolic process	biological process	TAS
GO:0007628	adult walking behavior	biological process	IEA
GO:0016020	membrane	cellular component	IEA
GO:0044281	small molecule metabolic process	biological process	TAS
GO:0007040	lysosome organization	biological process	IEA
GO:0042552	myelination	biological process	IEA
GO:0042339	keratan sulfate metabolic process	biological process	TAS
GO:0006687	glycosphingolipid metabolic process	biological process	TAS
GO:0050884	neuromuscular process controlling posture	biological process	IEA
GO:0007605	sensory perception of sound	biological process	IEA
GO:0030203	glycosaminoglycan metabolic process	biological process	TAS
GO:0046982	protein heterodimerization activity	molecular function	IDA[6230359]
GO:0004563	beta-N-acetylhexosaminidase activity	molecular function	IEA

HEXA related KEGG pathways (count: 6)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa00531	glycosaminoglycan degradation	Glycosaminoglycan degradation
hsa00604	glycosphingolipid biosynthesis_ganglio_series	Glycosphingolipid biosynthesis - ganglio series
hsa00603	glycosphingolipid biosynthesis_globo_series	Glycosphingolipid biosynthesis - globo series
hsa00511	other glycan_degradation	Other glycan degradation
hsa04142	lysosome	Lysosome	Lysosomes are membrane-delimited organelles in animal cells ...... Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy. More...
hsa00520	amino sugar_and_nucleotide_sugar_metabolism	Amino sugar and nucleotide sugar metabolism

HEXA related BioCarta pathways (count: 0)

HEXA related Reactome pathways (count: 0)

HEXA related interactors from protein-protein interaction data in HPRD (count: 1)

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways