Gene Report

Basic Information

Approved Symbol	PRPF19
Approved Name	PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)
Previous Symbol	PRP19
Previous Name	PRP19/PSO4 homolog (S. cerevisiae)
Symbol Alias	UBOX4, NMP200, PSO4, hPSO4
Name Alias	nuclear matrix protein NMP200 related to splicing factor PRP19
Location	11q12.2
Position	chr11:60658019-60674061 (-)
External Links	Entrez Gene: 27339 Ensembl: ENSG00000110107 UCSC: uc001nqf.3 HGNC ID: 17896
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin

Positive relationships between PRPF19 and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
NMP200	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder
PRP19/PSO4 pre-mRNA processing factor 19 homolog	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between PRPF19 and other components at different levels (count: 0)

Positive relationship network of PRPF19 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between PRPF19 and MDD (count: 0)

Negative relationships between PRPF19 and other components at different levels (count: 0)

PRPF19 related SNPs in MK4MDD (count: 0)

PRPF19 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Pre-mRNA-processing factor 19	Q9UMS4	0(0/0)	Gene mapped

PRPF19 related GO terms (count: 22)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0034450	ubiquitin-ubiquitin ligase activity	molecular function	IDA[11435423]
GO:0000245	spliceosomal complex assembly	biological process	IMP[16332694]
GO:0000209	protein polyubiquitination	biological process	IDA[11435423]
GO:0005515	protein binding	molecular function	IPI
GO:0005819	spindle	cellular component	IEA
GO:0004842	ubiquitin-protein ligase activity	molecular function	IDA[11435423]
GO:0005634	nucleus	cellular component	IDA[11435423]
GO:0071013	catalytic step 2 spliceosome	cellular component	IDA[11991638]
GO:0045665	negative regulation of neuron differentiation	biological process	IEA
GO:0016607	nuclear speck	cellular component	IDA[16332694]
GO:0000974	Prp19 complex	cellular component	IDA
GO:0008610	lipid biosynthetic process	biological process	IEA
GO:0001833	inner cell mass cell proliferation	biological process	IEA
GO:0048711	positive regulation of astrocyte differentiation	biological process	IEA
GO:0005811	lipid particle	cellular component	IEA
GO:0048026	positive regulation of mRNA splicing, via spliceosome	biological process	IEA
GO:0005737	cytoplasm	cellular component	IDA[11435423]
GO:0000398	mRNA splicing, via spliceosome	biological process	IC[11991638]; IDA
GO:0006281	DNA repair	biological process	IEA
GO:0000151	ubiquitin ligase complex	cellular component	IEA
GO:0042802	identical protein binding	molecular function	IPI[16332694]
GO:0003677	DNA binding	molecular function	IEA

PRPF19 related KEGG pathways (count: 2)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04120	ubiquitin mediated_proteolysis	Ubiquitin mediated proteolysis	Protein ubiquitination plays an important role in eukaryotic...... Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates. More...
hsa03040	spliceosome	Spliceosome	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...

PRPF19 related BioCarta pathways (count: 0)

PRPF19 related Reactome pathways (count: 0)

PRPF19 related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
PRPF19	DNTT	No	in vitro;in vivo	12960389
PRPF19	EXOC7	No	yeast 2-hybrid	16189514

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways