Gene Report

Basic Information

Approved Symbol	TTR
Approved Name	transthyretin
Previous Symbol	PALB, CTS1
Previous Name	"prealbumin, amyloidosis type I", "carpal tunnel syndrome 1"
Symbol Alias	HsT2651, CTS
Location	18q12.1
Position	chr18:29178639-29178987 (+)
External Links	Entrez Gene: 7276 Ensembl: ENSG00000118271 UCSC: uc002kwx.4 HGNC ID: 12405
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin; Protein mapped

Positive relationships between TTR and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
TTR	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between TTR and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
TTR		Depression-like behaviors from animal model(depressive-like behavior)	cognition and behavior	Andrus, 2010	animal model		Differentially expressed depression genes hippocampus, (fold...... Differentially expressed depression genes hippocampus, (fold change > 2). More...

Positive relationship network of TTR in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between TTR and MDD (count: 0)

Negative relationships between TTR and other components at different levels (count: 0)

TTR related SNPs in MK4MDD (count: 0)

TTR related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Transthyretin	P02766	2(2/0)	Literature-origin

TTR related GO terms (count: 19)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0006766	vitamin metabolic process	biological process	TAS
GO:0046982	protein heterodimerization activity	molecular function	IEA
GO:0044267	cellular protein metabolic process	biological process	TAS
GO:0042562	hormone binding	molecular function	IEA
GO:0043234	protein complex	cellular component	IEA
GO:0030198	extracellular matrix organization	biological process	TAS
GO:0042802	identical protein binding	molecular function	IPI[19861125\|21740906\|21777382\|23792159]
GO:0001523	retinoid metabolic process	biological process	TAS
GO:0005179	hormone activity	molecular function	IEA
GO:0006775	fat-soluble vitamin metabolic process	biological process	TAS
GO:0005515	protein binding	molecular function	IPI[986177\|16716307\|20646067\|25416956]
GO:0005737	cytoplasm	cellular component	IEA
GO:0044281	small molecule metabolic process	biological process	TAS
GO:0042572	retinol metabolic process	biological process	IEA
GO:0005576	extracellular region	cellular component	NAS[14718574]; TAS
GO:0007603	phototransduction, visible light	biological process	TAS
GO:0006810	transport	biological process	IEA
GO:0005615	extracellular space	cellular component	IDA[16502470]
GO:0070062	extracellular exosome	cellular component	IDA[23376485\|23533145]

TTR related KEGG pathways (count: 0)

TTR related BioCarta pathways (count: 0)

TTR related Reactome pathways (count: 0)

TTR related interactors from protein-protein interaction data in HPRD (count: 19)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
TTR	ATF4	No	yeast 2-hybrid	16189514
TTR	MARK3	No	yeast 2-hybrid	16169070
TTR	TTR	Yes	in vitro	16185074
TTR	VIM	Yes	yeast 2-hybrid	16169070
TTR	APOA1	No	in vitro	10627502
TTR	HSPG2	No	in vitro;in vivo	9307034
TTR	SETDB1	Yes	yeast 2-hybrid	16169070
TTR	FEZ1	No	yeast 2-hybrid	16169070
TTR	LRP2	No	in vitro;in vivo	10982792
TTR	EEF1A1	No	yeast 2-hybrid	16169070
TTR	DDR1	No	yeast 2-hybrid	16169070
TTR	RBP4	No	in vitro;in vivo	11853533 , 574085 , 12593674 , 8089102
TTR	ST3GAL3	No	yeast 2-hybrid	16169070
TTR	CHD3	No	yeast 2-hybrid	16169070
TTR	IKBKAP	No	yeast 2-hybrid	16169070
TTR	PHYHIP	No	yeast 2-hybrid	16169070
TTR	C7orf20	No	yeast 2-hybrid	16169070
TTR	HNRNPH3	No	yeast 2-hybrid	16169070
TTR	AGER	No	in vitro	16716307

Gene Report

Gene mapped GO terms