Gene Report

Basic Information

Approved Symbol	SETDB1
Approved Name	SET domain, bifurcated 1
Symbol Alias	KG1T, KIAA0067, ESET, KMT1E, TDRD21
Name Alias	"tudor domain containing 21"
Location	1q21
Position	chr1:150936841-150937220 (+)
External Links	Entrez Gene: 9869 Ensembl: ENSG00000143379 UCSC: uc001evu.2 HGNC ID: 10761
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin; Protein mapped

Positive relationships between SETDB1 and MDD (count: 0)

Positive relationships between SETDB1 and other components at different levels (count: 4)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Relation Description
Name in Literature	Related Components
SETDB1		NAA15(NMDA receptor)	gene	Jiang Y, 2010	animal model	In wild-type mice, systemic treatment with the NR2B antagoni...... In wild-type mice, systemic treatment with the NR2B antagonist, Ro25-6981 [R-(R,S)-alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidine propranol], and hippocampal small interfering RNA-mediated NR2B/Grin2b(NMDA receptor subunit) knockdown resulted in behavioral changes similar to those elicited by the Setdb1 transgene. More...
SETDB1		Memory(impaired memory)	cognition and behavior	Jiang Y, 2010	animal model	Transgenic mice with increased Setdb1 expression in adult fo...... Transgenic mice with increased Setdb1 expression in adult forebrain neurons show antidepressant-like phenotypes in behavioral paradigms for anhedonia, despair, and learned helplessness. More...
SETDB1		anhedonic-like behavior from animal model(anhedonic-like behavior)	cognition and behavior	Jiang Y, 2010	animal model	Transgenic mice with increased Setdb1 expression in adult fo...... Transgenic mice with increased Setdb1 expression in adult forebrain neurons show antidepressant-like phenotypes in behavioral paradigms for anhedonia, despair, and learned helplessness. More...
SETDB1		Depression-like behaviors from animal model(depressive-like behavior)	cognition and behavior	Jiang Y, 2010	animal model	Transgenic mice with increased Setdb1 expression in adult fo...... Transgenic mice with increased Setdb1 expression in adult forebrain neurons show antidepressant-like phenotypes in behavioral paradigms for anhedonia, despair, and learned helplessness. More...

Positive relationship network of SETDB1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between SETDB1 and MDD (count: 0)

Negative relationships between SETDB1 and other components at different levels (count: 0)

SETDB1 related SNPs in MK4MDD (count: 0)

SETDB1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Histone-lysine N-methyltransferase SETDB1	Q15047	1(1/0)	Literature-origin

SETDB1 related GO terms (count: 18)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0018024	histone-lysine N-methyltransferase activity	molecular function	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0036124	histone H3-K9 trimethylation	biological process	IEA
GO:0005737	cytoplasm	cellular component	IDA
GO:0006351	transcription, DNA-templated	biological process	IEA
GO:0045471	response to ethanol	biological process	IEA
GO:0005634	nucleus	cellular component	IDA
GO:0001833	inner cell mass cell proliferation	biological process	IEA
GO:0033273	response to vitamin	biological process	IEA
GO:0043231	intracellular membrane-bounded organelle	cellular component	IDA
GO:0008270	zinc ion binding	molecular function	IEA
GO:0005886	plasma membrane	cellular component	IDA
GO:0000790	nuclear chromatin	cellular component	IEA
GO:0005515	protein binding	molecular function	IPI[16682412\|17066076\|17577629\|20871592\|21170338\|24705354]
GO:0005654	nucleoplasm	cellular component	IDA; TAS
GO:0003677	DNA binding	molecular function	IEA
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IEA
GO:0060348	bone development	biological process	IEA
GO:0006325	chromatin organization	biological process	TAS

SETDB1 related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa00310	lysine degradation	Lysine degradation

SETDB1 related BioCarta pathways (count: 0)

SETDB1 related Reactome pathways (count: 0)

SETDB1 related interactors from protein-protein interaction data in HPRD (count: 85)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
SETDB1	GIPC2	No	yeast 2-hybrid	16169070
SETDB1	TK1	No	yeast 2-hybrid	16169070
SETDB1	HIST1H3A	No	in vivo	11791185
SETDB1	TTR	Yes	yeast 2-hybrid	16169070
SETDB1	CLSTN1	No	yeast 2-hybrid	12421765
SETDB1	HSPB3	No	yeast 2-hybrid	16169070
SETDB1	RIF1	No	yeast 2-hybrid	15383276
SETDB1	TRIM28	No	in vitro;in vivo;yeast 2-hybrid	11959841
SETDB1	S100A10	Yes	yeast 2-hybrid	16169070
SETDB1	DLEU1	No	yeast 2-hybrid	16169070
SETDB1	TRIB3	No	yeast 2-hybrid	16169070
SETDB1	TXNDC9	No	yeast 2-hybrid	16169070
SETDB1	SAT1	Yes	yeast 2-hybrid	16169070
SETDB1	TPI1	No	yeast 2-hybrid	16169070
SETDB1	BARD1	No	yeast 2-hybrid	15383276
SETDB1	PHF10	No	yeast 2-hybrid	16169070
SETDB1	HDAC1	No	in vitro;in vivo	12398767
SETDB1	C11orf1	No	yeast 2-hybrid	16169070
SETDB1	BTBD2	No	yeast 2-hybrid	16169070
SETDB1	ASAH1	No	yeast 2-hybrid	16169070
SETDB1	ATF7IP	No	in vitro	14536086
SETDB1	PSMD11	Yes	yeast 2-hybrid	16169070
SETDB1	ERG	No	in vitro;in vivo;yeast 2-hybrid	11791185
SETDB1	GPS2	No	yeast 2-hybrid	16169070
SETDB1	TRDMT1	No	yeast 2-hybrid	16169070
SETDB1	PABPC4	No	yeast 2-hybrid	15383276
SETDB1	GSTO1	No	yeast 2-hybrid	16169070
SETDB1	BRIX1	No	yeast 2-hybrid	16169070
SETDB1	PLEKHA4	No	yeast 2-hybrid	16169070
SETDB1	CDK4	No	yeast 2-hybrid	16169070
SETDB1	VIM	Yes	yeast 2-hybrid	15383276
SETDB1	SULT1E1	No	yeast 2-hybrid	16169070
SETDB1	FLYWCH1	No	yeast 2-hybrid	16169070
SETDB1	QTRT1	No	yeast 2-hybrid	16169070
SETDB1	PIAS4	No	in vitro;yeast 2-hybrid	15383276
SETDB1	SIN3A	No	in vivo	12398767
SETDB1	PTPRS	No	yeast 2-hybrid	16169070
SETDB1	SUFU	No	yeast 2-hybrid	14611647
SETDB1	HIST3H3	No	in vitro;in vivo	11959841
SETDB1	DAP	No	yeast 2-hybrid	16169070
SETDB1	HMOX2	No	yeast 2-hybrid	16169070
SETDB1	POLA2	No	yeast 2-hybrid	16169070
SETDB1	HDAC2	Yes	in vitro;in vivo	12398767
SETDB1	SUMO2	No	yeast 2-hybrid	15383276 , 16713569
SETDB1	SKIL	No	yeast 2-hybrid	15231748
SETDB1	SNIP1	No	yeast 2-hybrid	15231748
SETDB1	MBD1	No	in vivo	17066076
SETDB1	SLC38A3	No	yeast 2-hybrid	16169070
SETDB1	PRKRA	No	yeast 2-hybrid	16169070
SETDB1	MRPL44	No	yeast 2-hybrid	16169070
SETDB1	ZNF24	No	yeast 2-hybrid	16169070
SETDB1	TCERG1	No	yeast 2-hybrid	15383276
SETDB1	TARDBP	No	yeast 2-hybrid	16169070
SETDB1	ULK2	No	yeast 2-hybrid	16169070
SETDB1	PPA1	No	yeast 2-hybrid	16169070
SETDB1	BHLHE40	No	yeast 2-hybrid	16169070
SETDB1	TOLLIP	Yes	yeast 2-hybrid	16169070
SETDB1	PGAM5	No	yeast 2-hybrid	16169070
SETDB1	MOBKL3	No	yeast 2-hybrid	16169070
SETDB1	AIFM1	No	yeast 2-hybrid	16169070
SETDB1	SERPINB9	No	yeast 2-hybrid	16169070
SETDB1	ORAI2	No	yeast 2-hybrid	16169070
SETDB1	ERH	No	yeast 2-hybrid	16169070
SETDB1	PPP1R8	No	yeast 2-hybrid	16169070
SETDB1	BAT3	No	yeast 2-hybrid	16169070
SETDB1	TSC22D1	No	yeast 2-hybrid	16169070
SETDB1	CCDC106	No	yeast 2-hybrid	16169070
SETDB1	TOB1	Yes	yeast 2-hybrid	16169070
SETDB1	PCDHA4	No	yeast 2-hybrid	16169070
SETDB1	SIN3B	No	in vivo	12398767
SETDB1	RNF10	No	yeast 2-hybrid	16169070
SETDB1	ZFP64	No	yeast 2-hybrid	16169070
SETDB1	CBX8	No	yeast 2-hybrid	16169070
SETDB1	KDM1A	No	yeast 2-hybrid	16169070
SETDB1	ECSIT	No	yeast 2-hybrid	16169070
SETDB1	DNMT3A	No	in vitro;in vivo	16682412
SETDB1	THAP8	No	yeast 2-hybrid	16169070
SETDB1	TRIM16	No	yeast 2-hybrid	16169070
SETDB1	OLFML3	No	yeast 2-hybrid	16169070
SETDB1	NIPSNAP3A	No	yeast 2-hybrid	16169070
SETDB1	USP11	No	yeast 2-hybrid	16169070
SETDB1	MAD2L1BP	No	yeast 2-hybrid	16169070
SETDB1	CRELD1	No	yeast 2-hybrid	16169070
SETDB1	PAFAH1B3	No	yeast 2-hybrid	16169070
SETDB1	ATF7IP2	No	in vitro;in vivo	15691849

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways