Gene Report

Basic Information

Approved Symbol	STIP1
Approved Name	stress-induced-phosphoprotein 1
Symbol Alias	HOP, STI1
Name Alias	Hsp70/Hsp90-organizing protein
Location	11q13
Position	chr11:63953587-63972020 (+)
External Links	Entrez Gene: 10963 Ensembl: ENSG00000168439 UCSC: uc001nyk.1 HGNC ID: 11387
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between STIP1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
STIP1	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between STIP1 and other components at different levels (count: 0)

Positive relationship network of STIP1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between STIP1 and MDD (count: 0)

Negative relationships between STIP1 and other components at different levels (count: 0)

STIP1 related SNPs in MK4MDD (count: 0)

STIP1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Stress-induced-phosphoprotein 1	P31948	0(0/0)	Gene mapped

STIP1 related GO terms (count: 9)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0006950	response to stress	biological process	TAS[1569099]

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0030544	Hsp70 protein binding	molecular function	IEA
GO:0005515	protein binding	molecular function	IPI
GO:0005794	Golgi apparatus	cellular component	TAS[1569099]
GO:0007411	axon guidance	biological process	TAS
GO:0005634	nucleus	cellular component	TAS[16130169]
GO:0008022	protein C-terminus binding	molecular function	IEA
GO:0043234	protein complex	cellular component	IEA
GO:0051087	chaperone binding	molecular function	IEA

STIP1 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa05020	prion diseases	Prion diseases	Prion diseases, also termed transmissible spongiform encepha...... Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of these diseases is thought to be associated with the conversion of a normal protein, PrPC, into an infectious, pathogenic form, PrPSc. The conversion is induced by prion infections (for example, variant Creutzfeldt-Jakob disease (vCJD), iatrogenic CJD, Kuru), mutations (familial CJD, Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia (FFI)) or unknown factors (sporadic CJD (sCJD)), and is thought to occur after PrPC has reached the plasma membrane or is re-internalized for degradation. The PrPSc form shows greater protease resistance than PrPC and accumulates in affected individuals, often in the form of extracellular plaques. Pathways that may lead to neuronal death comprise oxidative stress, regulated activation of complement, ubiquitin-proteasome and endosomal-lysosomal systems, synaptic alterations and dendritic atrophy, corticosteroid response, and endoplasmic reticulum stress. In addition, the conformational transition could lead to the lost of a beneficial activity of the natively folded protein, PrPC. More...

STIP1 related BioCarta pathways (count: 0)

STIP1 related Reactome pathways (count: 0)

STIP1 related interactors from protein-protein interaction data in HPRD (count: 7)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
STIP1	HSPA14	No	in vitro	10786835
STIP1	CDC37	No	in vitro	12437126
STIP1	HSPA1A	No	in vitro;in vivo	12161444 , 10786835
STIP1	SUMO4	No	in vivo	16236267
STIP1	PTGES3	No	in vitro	11809754
STIP1	HSP90AA1	No	in vitro;in vivo	10786835
STIP1	PRNP	No	in vivo	12093732

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways