Gene Report

Basic Information

Approved Symbol	P2RX7
Approved Name	purinergic receptor P2X, ligand-gated ion channel, 7
Symbol Alias	P2X7, MGC20089
Location	12q24
Position	chr12:121570622-121624354 (+)
External Links	Entrez Gene: 5027 Ensembl: ENSG00000089041 UCSC: uc001tzm.3 HGNC ID: 8537
No. of Studies (Positive/Negative)	6(5/1)
Type	Literature-origin; SNP mapped

Positive relationships between P2RX7 and MDD (count: 3)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
P2RX7	Lucae, 2006	patients and normal controls	P-value=0.0019	A non-synonymous coding SNP in the P2RX7 gene (rs2230912) wa...... A non-synonymous coding SNP in the P2RX7 gene (rs2230912) was significantly associated (P=0.0019) with MDD. More...
P2RX7	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder
P2RX7	Soronen, 2011	patients and normal controls	OR = 1.35, P-value = 0.0013, P-valueermuted P-value = 0.06, and OR = 1.44, P-value = 0.0031	The P2RX7 gene variants rs208294 and rs2230912 significantly...... The P2RX7 gene variants rs208294 and rs2230912 significantly elevated the risk for a familial mood disorder (OR = 1.35, P = 0.0013, permuted P = 0.06, and OR = 1.44, P = 0.0031, permuted P = 0.17, respectively). More...

Positive relationships between P2RX7 and other components at different levels (count: 7)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description
Name in Literature	Related Components
P2X7 receptor		FOS(c-Fos)	gene	Boucher, 2011	animal model		c-Fos expression in the dentate gyrus of the hippocampus and...... c-Fos expression in the dentate gyrus of the hippocampus and in the basolateral amygdala was seen in WT mice but not P2X7(-/-) mice following repeated forced swim. More...
P2X7 receptor		Amygdala(amygdala)	brain morphology and function	Boucher, 2011	animal model		c-Fos expression in the dentate gyrus of the hippocampus and...... c-Fos expression in the dentate gyrus of the hippocampus and in the basolateral amygdala was seen in WT mice but not P2X7(-/-) mice following repeated forced swim. More...
P2X7 receptor		Hippocampus(hippocampus)	brain morphology and function	Boucher, 2011	animal model		c-Fos expression in the dentate gyrus of the hippocampus and...... c-Fos expression in the dentate gyrus of the hippocampus and in the basolateral amygdala was seen in WT mice but not P2X7(-/-) mice following repeated forced swim. More...
P2X7 receptor		Adaptive coping response to repeated stress(adaptive coping response to repeated stress)	cognition and behavior	Boucher, 2011	animal model		Equivalent levels of immobility were observed in P2X7(-/-) m...... Equivalent levels of immobility were observed in P2X7(-/-) mice and wild-type (WT) mice on the first exposure to forced swim, but much greater immobility was seen in WT mice on second and third exposures. This suggests that P2X7(-/-) mice exhibit an impaired adaptive coping response to repeated stress. More...
P2X7 receptor		Anxiety-like behaviors from animal model(anxiety-like behavior)	cognition and behavior	Boucher, 2011	animal model		P2X7(-/-) mice showed greater anxiety-like behaviour in the ...... P2X7(-/-) mice showed greater anxiety-like behaviour in the EPM More...
P2RX7		Increased agitation(anxiety)	symptoms	Hejjas, 2009	patients and normal controls	P-value = 0.01	Both anxiety and depression scores increased as the number o...... Both anxiety and depression scores increased as the number of G-allele increased in the genotype groups (ANOVA for HADS-anxiety: P = 0.01, HADS-depression: P < 0.001) More...
P2RX7		Depressed mood(depression)	symptoms	Hejjas, 2009	patients and normal controls	P-value<0.01	Both anxiety and depression scores increased as the number o...... Both anxiety and depression scores increased as the number of G-allele increased in the genotype groups (ANOVA for HADS-anxiety: P = 0.01, HADS-depression: P < 0.001) More...

Positive relationship network of P2RX7 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between P2RX7 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
P2RX7	Green EK, 2009	Patients and nomal controls		Neither rs2230912 nor any of 8 other SNPs genotyped across P...... Neither rs2230912 nor any of 8 other SNPs genotyped across P2RX7 was found to be associated with mood disorder in general, nor specifically with bipolar or unipolar disorder. More...

Negative relationships between P2RX7 and other components at different levels (count: 0)

P2RX7 related SNPs in MK4MDD (count: 2)

#rs	Location	Annotation	No. of Studies (Positive/Negative)
rs2230912	chr12:121622196(Forward)	3_prime_UTR_variant; missense_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant; upstream_gene_variant	6(3/3)
rs208294	chr12:121600253(Forward)	3_prime_UTR_variant; 5_prime_UTR_variant; downstream_gene_variant; intron_variant; missense_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant	1(0/1)

P2RX7 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
P2X purinoceptor 7	Q99572	0(0/0)	Gene mapped

P2RX7 related GO terms (count: 94)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0032553	ribonucleotide binding	molecular function	IC[9038151]
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0006954	inflammatory response	biological process	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0050830	defense response to Gram-positive bacterium	biological process	IEA
GO:0005911	cell-cell junction	cellular component	IEA
GO:0043132	NAD transport	biological process	IEA
GO:0014049	positive regulation of glutamate secretion	biological process	IEA
GO:0051209	release of sequestered calcium ion into cytosol	biological process	IEA
GO:0002028	regulation of sodium ion transport	biological process	ISS[17785580]
GO:0030501	positive regulation of bone mineralization	biological process	ISS
GO:0007009	plasma membrane organization	biological process	IEA
GO:0005507	copper ion binding	molecular function	IEA
GO:0051592	response to calcium ion	biological process	IEA
GO:0005102	receptor binding	molecular function	ISS[17785580]
GO:0051259	protein oligomerization	biological process	IEA
GO:0043409	negative regulation of MAPK cascade	biological process	ISS
GO:0045919	positive regulation of cytolysis	biological process	ISS
GO:0042098	T cell proliferation	biological process	IEA
GO:0019228	regulation of action potential in neuron	biological process	IEA
GO:0035590	purinergic nucleotide receptor signaling pathway	biological process	IDA[9038151]
GO:0001916	positive regulation of T cell mediated cytotoxicity	biological process	IEA
GO:0042493	response to drug	biological process	IEA
GO:0008270	zinc ion binding	molecular function	IEA
GO:0000287	magnesium ion binding	molecular function	IEA
GO:0032059	bleb	cellular component	ISS
GO:0032755	positive regulation of interleukin-6 production	biological process	IEA
GO:0033198	response to ATP	biological process	IDA[9038151]
GO:0032060	bleb assembly	biological process	ISS
GO:0019835	cytolysis	biological process	IEA
GO:0016485	protein processing	biological process	IEA
GO:0005737	cytoplasm	cellular component	ISS
GO:0050718	positive regulation of interleukin-1 beta secretion	biological process	IDA[17036048]
GO:0032496	response to lipopolysaccharide	biological process	IEA
GO:0001614	purinergic nucleotide receptor activity	molecular function	IDA[9038151]
GO:0006900	membrane budding	biological process	IEA
GO:0019233	sensory perception of pain	biological process	ISS
GO:0010043	response to zinc ion	biological process	IEA
GO:0050717	positive regulation of interleukin-1 alpha secretion	biological process	IEA
GO:0043195	terminal bouton	cellular component	IEA
GO:0045087	innate immune response	biological process	TAS
GO:0032308	positive regulation of prostaglandin secretion	biological process	IEA
GO:0097110	scaffold protein binding	molecular function	IEA
GO:0051901	positive regulation of mitochondrial depolarization	biological process	IEA
GO:0016079	synaptic vesicle exocytosis	biological process	IEA
GO:0031668	cellular response to extracellular stimulus	biological process	IEA
GO:0010524	positive regulation of calcium ion transport into cytosol	biological process	IDA[9038151]
GO:0006509	membrane protein ectodomain proteolysis	biological process	IEA
GO:0007005	mitochondrion organization	biological process	IEA
GO:0034405	response to fluid shear stress	biological process	IEA
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	biological process	TAS
GO:0005887	integral to plasma membrane	cellular component	IC[9038151]
GO:0042981	regulation of apoptotic process	biological process	ISS
GO:0044254	multicellular organismal protein catabolic process	biological process	IEA
GO:0000902	cell morphogenesis	biological process	IEA
GO:0048873	homeostasis of number of cells within a tissue	biological process	IEA
GO:0014054	positive regulation of gamma-aminobutyric acid secretion	biological process	IEA
GO:0000187	activation of MAPK activity	biological process	IEA
GO:0032963	collagen metabolic process	biological process	IEA
GO:0048705	skeletal system morphogenesis	biological process	IEA
GO:0051495	positive regulation of cytoskeleton organization	biological process	ISS
GO:0006884	cell volume homeostasis	biological process	IEA
GO:0045779	negative regulation of bone resorption	biological process	ISS
GO:0005886	plasma membrane	cellular component	ISS[17785580]; TAS
GO:0046513	ceramide biosynthetic process	biological process	IEA
GO:0031594	neuromuscular junction	cellular component	IEA
GO:0005639	integral to nuclear inner membrane	cellular component	IEA
GO:0051709	regulation of killing of cells of other organism	biological process	NAS[17785580]
GO:0045332	phospholipid translocation	biological process	IEA
GO:0001530	lipopolysaccharide binding	molecular function	ISS
GO:0007166	cell surface receptor signaling pathway	biological process	ISS
GO:0043025	neuronal cell body	cellular component	IEA
GO:0009897	external side of plasma membrane	cellular component	IEA
GO:0009612	response to mechanical stimulus	biological process	IEA
GO:0042803	protein homodimerization activity	molecular function	NAS[17895406]
GO:0001845	phagolysosome assembly	biological process	IEA
GO:0046931	pore complex assembly	biological process	IDA[9038151]
GO:0016020	membrane	cellular component	IDA[17785580]
GO:0043234	protein complex	cellular component	IEA
GO:0006649	phospholipid transfer to membrane	biological process	IEA
GO:0072593	reactive oxygen species metabolic process	biological process	IEA
GO:0045121	membrane raft	cellular component	IEA
GO:0043065	positive regulation of apoptotic process	biological process	IEA
GO:0051602	response to electrical stimulus	biological process	IEA
GO:0004931	extracellular ATP-gated cation channel activity	molecular function	IDA[9038151]
GO:0043029	T cell homeostasis	biological process	IEA
GO:0051899	membrane depolarization	biological process	IDA[9038151]
GO:0005524	ATP binding	molecular function	IC[9038151]

P2RX7 related KEGG pathways (count: 2)

ID	Name	Brief Description	Full Description
Literature-origin KEGG pathway
hsa04020	calcium signaling_pathway	Calcium signaling pathway	Ca2+ that enters the cell from the outside is a principal so...... Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs). The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it. The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM). More...

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04080	neuroactive ligand_receptor_interaction	Neuroactive ligand-receptor interaction

P2RX7 related BioCarta pathways (count: 0)

P2RX7 related Reactome pathways (count: 0)

P2RX7 related interactors from protein-protein interaction data in HPRD (count: 4)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
P2RX7	PANX1	No	in vivo	17036048
P2RX7	ACTB	No	in vivo	11707406
P2RX7	SVIL	No	in vivo	11707406
P2RX7	EMP3	No	in vitro	12107182

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Literature-origin KEGG pathway

Gene mapped KEGG pathways