MK4MDD

Gene Report

Basic Information
Approved Symbol P2RX7
Approved Name purinergic receptor P2X, ligand-gated ion channel, 7
Symbol Alias P2X7, MGC20089
Location 12q24
Position chr12:121622606-121624354 (+)
External Links Entrez Gene: 5027
Ensembl: ENSG00000089041
UCSC: uc001tzm.3
HGNC ID: 8537
No. of Studies (Positive/Negative) 6(5/1) Help
Type Literature-origin; SNP mapped

Positive relationships between P2RX7 and MDD (count: 3)
Name in Literature Reference Research Type Statistical Result Relation Description Help
P2RX7 Lucae, 2006 patients and normal controls P-value=0.0019 A non-synonymous coding SNP in the P2RX7 gene (rs2230912) wa...... A non-synonymous coding SNP in the P2RX7 gene (rs2230912) was significantly associated (P=0.0019) with MDD. More...
P2RX7 Aston, 2005 patients and normal controls Genes altered in major depressive disorder Genes altered in major depressive disorder
P2RX7 Soronen, 2011 patients and normal controls OR = 1.35, P-value = 0.0013, P-valueermuted P-value = 0.06, and OR = 1.44, P-value = 0.0031 The P2RX7 gene variants rs208294 and rs2230912 significantly...... The P2RX7 gene variants rs208294 and rs2230912 significantly elevated the risk for a familial mood disorder (OR = 1.35, P = 0.0013, permuted P = 0.06, and OR = 1.44, P = 0.0031, permuted P = 0.17, respectively). More...

Positive relationships between P2RX7 and other components at different levels (count: 7) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of P2RX7 in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between P2RX7 and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description
P2RX7 Green EK, 2009 Patients and nomal controls Neither rs2230912 nor any of 8 other SNPs genotyped across P...... Neither rs2230912 nor any of 8 other SNPs genotyped across P2RX7 was found to be associated with mood disorder in general, nor specifically with bipolar or unipolar disorder. More...

Negative relationships between P2RX7 and other components at different levels (count: 0) Help
P2RX7 related SNPs in MK4MDD (count: 2)
P2RX7 related proteins in MK4MDD (count: 0)
P2RX7 related GO terms (count: 95)
P2RX7 related KEGG pathways (count: 2)
P2RX7 related BioCarta pathways (count: 0)
P2RX7 related Reactome pathways (count: 0)
P2RX7 related interactors from protein-protein interaction data in HPRD (count: 4)