MK4MDD

SNP Report

Basic Information
Name rs2230912 dbSNP Ensembl
Location Chrchr12:121184393(Forward)
Variant Alleles A/G
Ancestral Allele A
No. of Studies (Positive/Negative) 6 (3/3) Help

Positive relationship between rs2230912 and MDD (count: 2)
Reference Research Type Statistical Result Relation Description Help
Lucae, 2006 patients and normal controls P-value=0.0019 A non-synonymous coding SNP in the P2RX7 gene (rs2230912) wa...... A non-synonymous coding SNP in the P2RX7 gene (rs2230912) was significantly associated (P=0.0019) with MDD. More...
Bosker, 2010 patients and normal controls Significance of candidate SNPs for MDD identified from the l...... Significance of candidate SNPs for MDD identified from the literature within the GAIN MDD GWAS More...

Relationships between rs2230912 and other components at different levels (count: 2) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


Positive relationship network of rs2230912 in MK4MDD
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Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between rs2230912 and MDD (count: 3)
Reference Research Type Statistical Result Relation Description
Green EK, 2009 Patients and nomal controls Neither rs2230912 nor any of 8 other SNPs genotyped across P...... Neither rs2230912 nor any of 8 other SNPs genotyped across P2RX7 was found to be associated with mood disorder in general, nor specifically with bipolar or unipolar disorder. More...
Grigoroiu-Serbanescu M, 2009 Patients and nomal controls We found no allelic or genotypic association between rs22309...... We found no allelic or genotypic association between rs2230912 and BPI or Mdd-UP both in the national samples and in the combined European patient sample More...
Viikki M, 2011 Patients and nomal controls There were no differences in allele or genotype frequencies ...... There were no differences in allele or genotype frequencies of either rs2230912 or rs208294 between patient groups and controls. Neither rs2230912 nor rs208294 was associated with MDD or remission after SSRI or ECT. More...

Negative relationships between rs2230912 and other components at different levels (count: 0) Help
rs2230912 related genes (count: 1)