Gene Report

Basic Information

Approved Symbol	BRF2
Approved Name	BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like
Symbol Alias	FLJ11052, BRFU, TFIIIB50
Location	8p11.23
Position	chr8:37701398-37707431 (-)
External Links	Entrez Gene: 55290 Ensembl: ENSG00000104221 UCSC: uc003xkk.3 HGNC ID: 17298
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between BRF2 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
BRF2	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between BRF2 and other components at different levels (count: 0)

Positive relationship network of BRF2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between BRF2 and MDD (count: 0)

Negative relationships between BRF2 and other components at different levels (count: 0)

BRF2 related SNPs in MK4MDD (count: 0)

BRF2 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Transcription factor IIIB 50 kDa subunit	Q9HAW0	0(0/0)	Gene mapped

BRF2 related GO terms (count: 6)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0006355	regulation of transcription, DNA-dependent	biological process	IEA
GO:0006352	DNA-dependent transcription, initiation	biological process	IEA
GO:0008270	zinc ion binding	molecular function	IEA
GO:0010467	gene expression	biological process	TAS
GO:0006383	transcription from RNA polymerase III promoter	biological process	TAS
GO:0005654	nucleoplasm	cellular component	TAS

BRF2 related KEGG pathways (count: 0)

BRF2 related BioCarta pathways (count: 0)

BRF2 related Reactome pathways (count: 5)

ID	Name	Description
Gene mapped Reactome pathways
REACT_1788	transcription	Transcription by RNA Polymerase I, RNA Polymerase III and tr...... Transcription by RNA Polymerase I, RNA Polymerase III and transcription from mitochondrial promoters. More...
REACT_571	rna polymerase_iii_transcription_initiation_from_type_3_promoter	The metazoan-specific type 3 promoters, which are exemplifie...... The metazoan-specific type 3 promoters, which are exemplified by the human U6 promoter, recruit a complex variously called the snRNA activating protein complex , the PSE binding protein , or the PSE transcription factor. The complex contains five types of subunits and binds to the PSE. Type 3 promoters also recruit Brf2-TFIIIB through a combination of protein-protein contacts with SNAPc and a direct association of the TBP component of Brf2-TFIIIB with the TATA box. This then allows RNA polymerase III to join the complex. The down stream element. The octamer sequence recruits the POU domain protein Oct-1 , and the SPH element recruits a zinc finger protein known as Staf or SPH binding factor. More...
REACT_281	rna polymerase_iii_transcription_initiation	There are three basic types of RNA polymerase III promoters....... There are three basic types of RNA polymerase III promoters. The three types of RNA polymerase III promoters are known as type 1, type 2, and type 3 promoters. Type 1 promoters are found in the 5S genes and consist of a gene-internal element called the internal control region. Type 2 promoters are found in tRNA genes, Adenovirus 2 VAI gene, and other genes. These promoters consists of two gene-internal elements called the A and the B boxes. Type 3 promoters consist of a distal sequence element. Some promoters combine elements from type 2 and 3 promoters. For example, the S. cerevisiae U6 promoter, also shown in the figure, contains the TATA box typical of type 3 promoters and the A and B boxes typical of type 2 promoters. Moreover, in S. pombe, nearly all tRNA and 5S genes contain a TATA box in addition to gene-internal elements, and the TATA box is required for transcription. More...
REACT_21352	rna polymerase_i_iii_and_mitochondrial_transcription	Transcription by RNA Polymerase I, RNA Polymerase III and tr...... Transcription by RNA Polymerase I, RNA Polymerase III and transcription from mitochondrial promoters. More...
REACT_1371	rna polymerase_iii_transcription	RNA polymerase III is one of three types of nuclear RNA poly...... RNA polymerase III is one of three types of nuclear RNA polymerases present in eucaryotic cells. About 10% of the total transcription in dividing cells can be attributed to its activity. It synthesizes an eclectic collection of catalytic or structural RNA molecules, some of which are involved in protein synthesis, pre-mRNA splicing, tRNA processing, and the control of RNA polymerase II elongation, whereas some others have still unknown functions. Like other RNA polymerases, RNA polymerase III cannot recognize its target promoters directly. Instead it is recruited to specific promoter sequences through the help of transcription factors. There are three basic types of RNA polymerase III promoters, called types 1, 2, and 3. Although in vivo, RNA polymerase III may be recruited to these promoters as part of a large complex , in vitro the reaction can be divided into several steps. First, the promoter elements are recognized by DNA binding factors, which then recruit a factor known as TFIIIB. TFIIIB itself then directly contacts RNA polymerase III. In human cells but not in S. cerevisiae, there are at least two versions of TFIIIB. One contains TBP, Bdp1, and Brf1. More...

BRF2 related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
BRF2	SNAPC4	No	in vitro	12621023
BRF2	RBL2	No	in vivo	10330166
BRF2	TBP	No	in vitro;in vivo	11564744

Gene Report

Gene mapped GO terms

Gene mapped Reactome pathways