Gene Report

Basic Information

Approved Symbol	BRD4
Approved Name	bromodomain containing 4
Previous Name	"bromodomain-containing 4"
Symbol Alias	HUNKI, MCAP, CAP, HUNK1
Name Alias	"chromosome-associated protein"
Location	19p13.12
Position	chr19:15443101-15443354 (-)
External Links	Entrez Gene: 23476 Ensembl: ENSG00000141867 UCSC: uc002nar.3 HGNC ID: 13575
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between BRD4 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
CAP	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between BRD4 and other components at different levels (count: 0)

Positive relationship network of BRD4 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between BRD4 and MDD (count: 0)

Negative relationships between BRD4 and other components at different levels (count: 0)

BRD4 related SNPs in MK4MDD (count: 0)

BRD4 related proteins in MK4MDD (count: 0)

BRD4 related GO terms (count: 30)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0002039	p53 binding	molecular function	IDA[23317504]
GO:0005737	cytoplasm	cellular component	IDA
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	biological process	IMP[10938129]
GO:0003682	chromatin binding	molecular function	IDA[20871596\|23086925\|23317504\|23728299]
GO:0044154	histone H3-K14 acetylation	biological process	IEA
GO:0043388	positive regulation of DNA binding	biological process	IEA
GO:0007059	chromosome segregation	biological process	IEA
GO:0043983	histone H4-K12 acetylation	biological process	IEA
GO:0001833	inner cell mass cell proliferation	biological process	IEA
GO:0005634	nucleus	cellular component	IDA[20871596]
GO:0000790	nuclear chromatin	cellular component	IEA
GO:0008024	positive transcription elongation factor complex b	cellular component	IEA
GO:0006338	chromatin remodeling	biological process	IDA[23728299]
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	biological process	IDA[19103749\|23086925]; IMP[18039861]
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[23086925\|23317504]
GO:0005654	nucleoplasm	cellular component	IDA
GO:0006351	transcription, DNA-templated	biological process	IEA
GO:0006468	protein phosphorylation	biological process	IEA
GO:0005515	protein binding	molecular function	IPI[17023018\|17189189\|17474147\|18305892\|19103749\|22645123\|23455924\|23686307\|23728299\|24360279\|24525235]
GO:0003677	DNA binding	molecular function	IEA
GO:1901407	regulation of phosphorylation of RNA polymerase II C-terminal domain	biological process	IDA[23086925]
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	biological process	IDA[19103749]
GO:0050727	regulation of inflammatory response	biological process	IDA[19103749]
GO:0016032	viral process	biological process	IEA
GO:2000002	negative regulation of DNA damage checkpoint	biological process	IMP[23728299]
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	biological process	IMP[18039861]
GO:0006974	cellular response to DNA damage stimulus	biological process	IEA; IMP[23728299]
GO:0005694	chromosome	cellular component	IDA[23728299]
GO:0070577	lysine-acetylated histone binding	molecular function	IDA[20871596\|23086925\|23317504\|23728299]
GO:0000794	condensed nuclear chromosome	cellular component	IDA[10938129]

BRD4 related KEGG pathways (count: 0)

BRD4 related BioCarta pathways (count: 0)

BRD4 related Reactome pathways (count: 0)

BRD4 related interactors from protein-protein interaction data in HPRD (count: 8)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
BRD4	CLDN1	No	yeast 2-hybrid	16169070
BRD4	CHFR	No	yeast 2-hybrid	16169070
BRD4	RFC1	No	in vitro;in vivo	12192049
BRD4	CCNT2	No	in vivo	16109376
BRD4	PRPF40A	No	yeast 2-hybrid	15231748
BRD4	CCNT1	No	in vivo	16109376
BRD4	C7orf25	No	yeast 2-hybrid	16169070
BRD4	RFC4	No	in vitro;in vivo	12192049

Gene Report

Gene mapped GO terms