Gene Report

Basic Information

Approved Symbol	EEF1E1
Approved Name	eukaryotic translation elongation factor 1 epsilon 1
Previous Symbol	P18
Symbol Alias	AIMP3
Name Alias	"aminoacyl tRNA synthetase complex-interacting multifunctional protein 3"
Location	6p24.3
Position	chr6:8102755-8102795 (-)
External Links	Entrez Gene: 9521 Ensembl: ENSG00000124802 UCSC: uc003mxz.3 HGNC ID: 3212
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between EEF1E1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
EEF1E1	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between EEF1E1 and other components at different levels (count: 0)

Positive relationship network of EEF1E1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between EEF1E1 and MDD (count: 0)

Negative relationships between EEF1E1 and other components at different levels (count: 0)

EEF1E1 related SNPs in MK4MDD (count: 0)

EEF1E1 related proteins in MK4MDD (count: 0)

EEF1E1 related GO terms (count: 18)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0008285	negative regulation of cell proliferation	biological process	ISS
GO:0003746	translation elongation factor activity	molecular function	IBA
GO:0043065	positive regulation of apoptotic process	biological process	ISS
GO:0010467	gene expression	biological process	TAS
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	biological process	ISS
GO:0001887	selenium compound metabolic process	biological process	TAS
GO:0005515	protein binding	molecular function	IPI[21516116\|22190034\|25416956]
GO:0005829	cytosol	cellular component	TAS
GO:0006418	tRNA aminoacylation for protein translation	biological process	TAS
GO:2000774	positive regulation of cellular senescence	biological process	IDA[25465621]
GO:0005634	nucleus	cellular component	IBA; ISS
GO:0006749	glutathione metabolic process	biological process	IBA
GO:0006414	translational elongation	biological process	IBA
GO:0070062	extracellular exosome	cellular component	IDA[23376485]
GO:0004364	glutathione transferase activity	molecular function	IBA
GO:0044281	small molecule metabolic process	biological process	TAS
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS
GO:0005737	cytoplasm	cellular component	IBA; ISS

EEF1E1 related KEGG pathways (count: 0)

EEF1E1 related BioCarta pathways (count: 0)

EEF1E1 related Reactome pathways (count: 3)

ID	Name	Description
Gene mapped Reactome pathways
REACT_71	gene expression	Gene Expression covers the process of transcription of mRNA ...... Gene Expression covers the process of transcription of mRNA genes, the processing of pre-mRNA, and its subsequent translation to result in a protein. The expression of non-protein-coding genes is not included in this section yet. However, the transcription of RNAs other than mRNA is described in the section on transcription; in the sections 'RNA Polymerase I Transcription', and 'RNA Polymerase III Transcription'. More...
REACT_15306	cytosolic trna_aminoacylation	Cytosolic tRNA synthetases catalyze the reactions of tRNAs e...... Cytosolic tRNA synthetases catalyze the reactions of tRNAs encoded in the nuclear genome, their cognate amino acids, and ATP to form aminoacyl-tRNAs, AMP, and pyrophosphate. Eight of the tRNA synthetases, those specific for arginine, aspartate, glutamate and proline, glutamine, isoleucine, leucine, lysine, and methionine, associate to form a complex with three accessory proteins. Each of the component synthetases is active in vitro as a purified protein; complex formation is thought to channel aminoacylated tRNAs more efficiently to the site of protein synthesis in mRNA:ribosome complexes. More...
REACT_15482	trna aminoacylation	tRNA synthetases catalyze the ligation of tRNAs to their cog...... tRNA synthetases catalyze the ligation of tRNAs to their cognate amino acids in an ATP-dependent manner. The reaction proceeds in two steps. First, amino acid and ATP form an aminoacyl adenylate molecule, releasing pyrophosphate. The aminoacyl adenylate remains associated with the synthetase enzyme where, in the second step it reacts with tRNA to form aminoacyl tRNA and AMP. The rapid hydrolysis of pyrophosphate makes these reactions essentially irreversible under physiological conditions. Specificity of the tRNA charging reactions is achieved both by specific recognition of amino acid and tRNA substrates by the synthetase, and by an editing process in which incorrect aminoacyl adenylate molecules. The tRNA synthetases can be divided into two structural classes based on conserved amino acid sequence features. A single synthetase mediates the charging of all of the tRNA species specific for any one amino acid but, with three exceptions, glycine, lysine, and glutamine, the synthetase that catalyzes aminoacylation of mitochondrial tRNAs is encoded by a different gene than the one that acts on mitochondrial tRNAs. Both mitochondrial and cytosolic tRNA synthetase enzymes are encoded by genes in the nuclear genome. A number of tRNA synthetases are known to have functions distinct from tRNA charging. Additionally, mutations in several of the tRNA synthetases, often affecting protein domains that are dispensable in vitro for aminoacyl tRNA synthesis, are associated with a diverse array of neurological and other diseases. These findings raise interest into the role of these enzymes in human development and disease. More...

EEF1E1 related interactors from protein-protein interaction data in HPRD (count: 2)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
EEF1E1	ATM	Yes	in vitro;in vivo	15680327
EEF1E1	ATR	No	in vitro;in vivo	15680327

Gene Report

Gene mapped GO terms

Gene mapped Reactome pathways