Gene Report

Basic Information

Approved Symbol	KLK6
Approved Name	kallikrein-related peptidase 6
Previous Symbol	PRSS9, PRSS18
Previous Name	"protease, serine, 18", "kallikrein 6 (neurosin, zyme)"
Symbol Alias	Bssp, Klk7, neurosin
Location	19q13.3
Position	chr19:51472746-51472929 (-)
External Links	Entrez Gene: 5653 Ensembl: ENSG00000167755 UCSC: uc002pui.3 HGNC ID: 6367
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between KLK6 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
KLK6	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder

Positive relationships between KLK6 and other components at different levels (count: 0)

Positive relationship network of KLK6 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between KLK6 and MDD (count: 0)

Negative relationships between KLK6 and other components at different levels (count: 0)

KLK6 related SNPs in MK4MDD (count: 0)

KLK6 related proteins in MK4MDD (count: 0)

KLK6 related GO terms (count: 25)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0010975	regulation of neuron projection development	biological process	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0042445	hormone metabolic process	biological process	NAS[11668196]
GO:0042982	amyloid precursor protein metabolic process	biological process	NAS[12709365]
GO:0005739	mitochondrion	cellular component	IEA
GO:0005615	extracellular space	cellular component	IDA[16502470]
GO:0005576	extracellular region	cellular component	IDA[11668196]
GO:0005737	cytoplasm	cellular component	IDA[11668196]
GO:0042246	tissue regeneration	biological process	NAS[12878203]
GO:0031965	nuclear membrane	cellular component	IDA
GO:0005730	nucleolus	cellular component	IEA
GO:0015630	microtubule cytoskeleton	cellular component	IDA
GO:0004252	serine-type endopeptidase activity	molecular function	IDA[16885167]; NAS[12878203]
GO:0045171	intercellular bridge	cellular component	IDA
GO:0016485	protein processing	biological process	IBA
GO:0005515	protein binding	molecular function	IPI[12709365\|12878203]
GO:0016540	protein autoprocessing	biological process	NAS[12878203]
GO:0042552	myelination	biological process	NAS[11668196]
GO:0009611	response to wounding	biological process	NAS[12016211]
GO:0030574	collagen catabolic process	biological process	NAS[12878203]
GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway	biological process	IDA[16885167]
GO:0005654	nucleoplasm	cellular component	IDA
GO:0045595	regulation of cell differentiation	biological process	NAS[11668196]
GO:0070997	neuron death	biological process	IMP[22166940]
GO:0007417	central nervous system development	biological process	NAS[12589961]
GO:0005783	endoplasmic reticulum	cellular component	IEA

KLK6 related KEGG pathways (count: 0)

KLK6 related BioCarta pathways (count: 0)

KLK6 related Reactome pathways (count: 0)

KLK6 related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
KLK6	SNCA	No	in vitro	12928483
KLK6	SERPINC1	No	in vitro	12878203
KLK6	SERPINF2	No	in vitro	12878203

Gene Report

Literature-origin GO terms

Gene mapped GO terms