Gene Report

Basic Information

Approved Symbol	HSPA2
Approved Name	heat shock 70kDa protein 2
Previous Name	"heat shock 70kD protein 2"
Location	14q23
Position	chr14:65009488-65009955 (+)
External Links	Entrez Gene: 3306 Ensembl: ENSG00000126803 UCSC: uc001xhk.4 HGNC ID: 5235
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin; Protein mapped

Positive relationships between HSPA2 and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
HSPA2	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder
HSPA2	Belzeaux, 2010	patients and normal controls		We also observed that variations in other mRNA expression we...... We also observed that variations in other mRNA expression were associated with treatment efficacy or clinical improvement (CREB1, HDAC5, HSPA2, HTR1B, HTR2A, and SLC6A4/5HTT). More...

Positive relationships between HSPA2 and other components at different levels (count: 0)

Positive relationship network of HSPA2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between HSPA2 and MDD (count: 0)

Negative relationships between HSPA2 and other components at different levels (count: 0)

HSPA2 related SNPs in MK4MDD (count: 0)

HSPA2 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Heat shock-related 70 kDa protein 2	P54652	1(1/0)	Literature-origin

HSPA2 related GO terms (count: 31)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0016020	membrane	cellular component	IDA[19946888]
GO:0070062	extracellular exosome	cellular component	IDA[19056867]
GO:0051861	glycolipid binding	molecular function	IEA
GO:0009408	response to heat	biological process	ISS
GO:0000795	synaptonemal complex	cellular component	IEA
GO:0042026	protein refolding	biological process	IDA[21231916]
GO:0090084	negative regulation of inclusion body assembly	biological process	IDA[21231916]
GO:1901896	positive regulation of calcium-transporting ATPase activity	biological process	IEA
GO:0007286	spermatid development	biological process	IEA
GO:0007140	male meiosis	biological process	TAS[8622925]
GO:0051082	unfolded protein binding	molecular function	IDA[21231916]
GO:0001673	male germ cell nucleus	cellular component	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0007141	male meiosis I	biological process	IEA
GO:0031662	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle	biological process	IEA
GO:0005634	nucleus	cellular component	IDA[21630459]
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0072687	meiotic spindle	cellular component	ISS
GO:0072562	blood microparticle	cellular component	IDA[22516433]
GO:0009986	cell surface	cellular component	IEA
GO:0070194	synaptonemal complex disassembly	biological process	IEA
GO:0043209	myelin sheath	cellular component	IEA
GO:0036128	CatSper complex	cellular component	ISS
GO:0006986	response to unfolded protein	biological process	TAS[7829106]
GO:0009409	response to cold	biological process	ISS
GO:0005829	cytosol	cellular component	IDA[21231916]
GO:0005515	protein binding	molecular function	IPI[16189514\|16713569\|25036637\|25416956]
GO:0019899	enzyme binding	molecular function	IPI[23921388]
GO:0007283	spermatogenesis	biological process	ISS
GO:0005739	mitochondrion	cellular component	IEA
GO:0005524	ATP binding	molecular function	IEA

HSPA2 related KEGG pathways (count: 4)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa03040	spliceosome	Spliceosome	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...
hsa04010	mapk signaling_pathway	MAPK signaling pathway	The mitogen-activated protein kinase (MAPK) cascade is a hig...... The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. More...
hsa04144	endocytosis	Endocytosis	Endocytosis is a mechanism for cells to remove ligands, nutr...... Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type. More...
hsa04612	antigen processing_and_presentation	Antigen processing and presentation

HSPA2 related BioCarta pathways (count: 0)

HSPA2 related Reactome pathways (count: 0)

HSPA2 related interactors from protein-protein interaction data in HPRD (count: 5)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
HSPA2	MEOX2	No	yeast 2-hybrid	16713569
HSPA2	HSPBP1	No	yeast 2-hybrid	16189514 , 16713569
HSPA2	EWSR1	No	yeast 2-hybrid	16713569
HSPA2	CDK1	No	in vitro	9247342
HSPA2	MAP3K3	No	in vivo	1474216

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways