Gene Report

Basic Information

Approved Symbol	ABCA8
Approved Name	ATP-binding cassette, sub-family A (ABC1), member 8
Symbol Alias	KIAA0822
Location	17q24
Position	chr17:66863430-66951533 (-)
External Links	Entrez Gene: 10351 Ensembl: ENSG00000141338 UCSC: uc002jhp.3 HGNC ID: 38
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin

Positive relationships between ABCA8 and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
ABCA8	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder
ABCA8	Sequeira A, 2009	patients and nomal controls	Group: P-value=0.006, F=6.5; Substance: P-value=0.009, F=8.3	Genes differentially expressed after an ANCOVA analysis betw...... Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). More...

Positive relationships between ABCA8 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
ABCA8		Suicide(suicide)	symptoms	Sequeira A, 2009	patients and nomal controls	Group: P-value=0.006, F=6.5; Substance: P-value=0.009, F=8.3	Genes differentially expressed after an ANCOVA analysis betw...... Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). More...

Positive relationship network of ABCA8 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between ABCA8 and MDD (count: 0)

Negative relationships between ABCA8 and other components at different levels (count: 0)

ABCA8 related SNPs in MK4MDD (count: 0)

ABCA8 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
ATP-binding cassette sub-family A member 8	O94911	0(0/0)	Gene mapped

ABCA8 related GO terms (count: 11)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0032553	ribonucleotide binding	molecular function	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0055085	transmembrane transport	biological process	TAS
GO:0006810	transport	biological process	IDA[12379217]
GO:0005524	ATP binding	molecular function	IEA
GO:0005743	mitochondrial inner membrane	cellular component	IEA
GO:0016021	integral to membrane	cellular component	IEA
GO:0005886	plasma membrane	cellular component	TAS
GO:0042626	ATPase activity, coupled to transmembrane movement of substances	molecular function	IDA[12379217]

ABCA8 related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa02010	abc transporters	ABC transporters	The ATP-binding cassette (ABC) transporters form one of the ...... The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD). More...

ABCA8 related BioCarta pathways (count: 0)

ABCA8 related Reactome pathways (count: 0)

ABCA8 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways