Gene Report

Basic Information

Approved Symbol	ENPP2
Approved Name	ectonucleotide pyrophosphatase/phosphodiesterase 2
Previous Symbol	PDNP2
Symbol Alias	ATX, PD-IALPHA
Name Alias	"autotaxin"
Location	8q24.1
Position	chr8:120685513-120685644 (-)
External Links	Entrez Gene: 5168 Ensembl: ENSG00000136960 UCSC: uc003yos.2 HGNC ID: 3357
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin

Positive relationships between ENPP2 and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
ENPP2	Aston, 2005	patients and normal controls		Genes altered in major depressive disorder Genes altered in major depressive disorder
ENPP2	Sibille E, 2009	animal model; patients and nomal controls	R=0.88, P-value<5E-6; y slope=1.14	Downregulated in MDD patients Downregulated in MDD patients

Positive relationships between ENPP2 and other components at different levels (count: 0)

Positive relationship network of ENPP2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between ENPP2 and MDD (count: 0)

Negative relationships between ENPP2 and other components at different levels (count: 0)

ENPP2 related SNPs in MK4MDD (count: 0)

ENPP2 related proteins in MK4MDD (count: 0)

ENPP2 related GO terms (count: 28)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0006928	movement of cell or subcellular component	biological process	TAS[1733949]
GO:0030334	regulation of cell migration	biological process	IDA[1733949]
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[1733949]
GO:0009395	phospholipid catabolic process	biological process	IDA[15280042]
GO:0008270	zinc ion binding	molecular function	ISS
GO:0006955	immune response	biological process	IEA
GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity	molecular function	IEA
GO:0004551	nucleotide diphosphatase activity	molecular function	IEA
GO:0005886	plasma membrane	cellular component	TAS[8579579]
GO:0003676	nucleic acid binding	molecular function	IEA
GO:0005615	extracellular space	cellular component	IDA[15280042]; ISS
GO:0004622	lysophospholipase activity	molecular function	IDA[15280042\|21240271]
GO:0005044	scavenger receptor activity	molecular function	IEA
GO:0030247	polysaccharide binding	molecular function	IEA
GO:0006935	chemotaxis	biological process	NAS[7982964]
GO:0005509	calcium ion binding	molecular function	ISS
GO:0004528	phosphodiesterase I activity	molecular function	IEA
GO:0045765	regulation of angiogenesis	biological process	IEA
GO:0006796	phosphate-containing compound metabolic process	biological process	TAS[8579579]
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	biological process	IDA[18054784]
GO:0016787	hydrolase activity	molecular function	TAS[7982964]
GO:0034638	phosphatidylcholine catabolic process	biological process	IDA[21240271]
GO:0090305	nucleic acid phosphodiester bond hydrolysis	biological process	IEA; TAS[7982964]
GO:0008134	transcription factor binding	molecular function	TAS[8586446]
GO:0010634	positive regulation of epithelial cell migration	biological process	IGI[18054784]; IMP[18054784]
GO:2000394	positive regulation of lamellipodium morphogenesis	biological process	IGI[18054784]
GO:0005887	integral component of plasma membrane	cellular component	TAS[1733949]
GO:0006898	receptor-mediated endocytosis	biological process	IEA

ENPP2 related KEGG pathways (count: 1)

Gene mapped KEGG pathways
ID	Name	Brief Description	Full Description
hsa00565	ether lipid_metabolism	Ether lipid metabolism

ENPP2 related BioCarta pathways (count: 0)

ENPP2 related Reactome pathways (count: 0)

ENPP2 related interactors from protein-protein interaction data in HPRD (count: 0)

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways