MK4MDD

Gene Report

Basic Information
Approved Symbol LTA
Approved Name lymphotoxin alpha
Previous Symbol TNFB
Previous Name "lymphotoxin alpha (TNF superfamily, member 1)"
Symbol Alias TNFSF1, LT
Name Alias "TNF superfamily member 1"
Location 6p21.3
Position chr6:31541471-31542101 (+)
External Links Entrez Gene: 4049
Ensembl: ENSG00000226979
UCSC: uc011dnu.2
HGNC ID: 6709
No. of Studies (Positive/Negative) 2(1/1) Help
Type Literature-origin

Positive relationships between LTA and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description Help
lymphotoxin alpha Shelton, 2011 patients and normal controls Gene set analysis suggested up-regulation of a variety of pr...... Gene set analysis suggested up-regulation of a variety of pro- and anti-inflammatory cytokines, including interleukin 1alpha (IL-1alpha), IL-2, IL-3, IL-5, IL-8, IL-9, IL-10, IL-12A, IL-13, IL-15, IL-18, interferon gamma (IFNgamma), and lymphotoxin alpha (TNF superfamily member 1). More...

Positive relationships between LTA and other components at different levels (count: 0) Help
Positive relationship network of LTA in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between LTA and MDD (count: 1)
Name in Literature Reference Research Type Statistical Result Relation Description
TNF-beta Jun TY, 2003 Patients and nomal controls The genotype and allele distribution in patients with MDD wa...... The genotype and allele distribution in patients with MDD was similar to that of the controls. More...

Negative relationships between LTA and other components at different levels (count: 0) Help
LTA related SNPs in MK4MDD (count: 0)
LTA related proteins in MK4MDD (count: 0)
LTA related GO terms (count: 23)
LTA related KEGG pathways (count: 3)
LTA related BioCarta pathways (count: 4)
LTA related Reactome pathways (count: 0)
LTA related interactors from protein-protein interaction data in HPRD (count: 9)