Gene Report

Basic Information

Approved Symbol	GATA1
Approved Name	GATA binding protein 1 (globin transcription factor 1)
Previous Symbol	GF1
Previous Name	GATA-binding protein 1 (globin transcription factor 1)
Symbol Alias	ERYF1, NFE1, GATA-1
Location	Xp11.23
Position	chrX:48644982-48652718 (+)
External Links	Entrez Gene: 2623 Ensembl: ENSG00000102145 UCSC: uc004dkq.4 HGNC ID: 4170
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between GATA1 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
GATA1	Kang HJ, 2012	patients and normal controls		Here we use microarray gene profiling and electron microscop...... Here we use microarray gene profiling and electron microscopic stereology to reveal lower expression of synaptic-function-related genes (CALM2, SYN1, RAB3A, RAB4B and TUBB4) in the dlPFC of subjects with MDD and a corresponding lower number of synapses. We also identify a transcriptional repressor, GATA1, expression of which is higher in MDD More...

Positive relationships between GATA1 and other components at different levels (count: 0)

Positive relationship network of GATA1 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between GATA1 and MDD (count: 0)

Negative relationships between GATA1 and other components at different levels (count: 0)

GATA1 related SNPs in MK4MDD (count: 0)

GATA1 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Erythroid transcription factor	P15976	0(0/0)	Gene mapped

GATA1 related GO terms (count: 49)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005515	protein binding	molecular function	IPI[11418466]
GO:0005634	nucleus	cellular component	IDA
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	molecular function	IDA[2467208]
GO:0071733	transcriptional activation by promoter-enhancer looping	biological process	ISS
GO:0031965	nuclear membrane	cellular component	IDA
GO:0005654	nucleoplasm	cellular component	TAS
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[12200364]
GO:0007267	cell-cell signaling	biological process	IEA
GO:0008270	zinc ion binding	molecular function	IEA
GO:0070742	C2H2 zinc finger domain binding	molecular function	IPI[12483298]
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	molecular function	IDA[15920471]
GO:0048821	erythrocyte development	biological process	IMP[10700180]
GO:0030222	eosinophil differentiation	biological process	IEP[8507862]
GO:0033690	positive regulation of osteoblast proliferation	biological process	IEA
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	molecular function	IEA
GO:0000976	transcription regulatory region sequence-specific DNA binding	molecular function	IMP[10700180]
GO:0002039	p53 binding	molecular function	IEA
GO:0003682	chromatin binding	molecular function	IEA
GO:0001701	in utero embryonic development	biological process	IEA
GO:0030218	erythrocyte differentiation	biological process	IEP[7678994]
GO:0008584	male gonad development	biological process	IMP[10700180]
GO:0030502	negative regulation of bone mineralization	biological process	IEA
GO:0010724	regulation of definitive erythrocyte differentiation	biological process	IDA[15920471]
GO:0030221	basophil differentiation	biological process	IEP[7678994]
GO:0017053	transcriptional repressor complex	cellular component	IDA[15920471]
GO:0035162	embryonic hemopoiesis	biological process	IEA
GO:0003677	DNA binding	molecular function	IDA[11418466]
GO:0070527	platelet aggregation	biological process	IMP[15701726]
GO:0043565	sequence-specific DNA binding	molecular function	IMP[12200364]
GO:0030220	platelet formation	biological process	IMP[12483298]
GO:0008285	negative regulation of cell proliferation	biological process	IEA
GO:2000678	negative regulation of transcription regulatory region DNA binding	biological process	IDA[15920471]
GO:0008301	DNA binding, bending	molecular function	IEA
GO:0005667	transcription factor complex	cellular component	IDA[15920471]
GO:0010559	regulation of glycoprotein biosynthetic process	biological process	IMP[15701726]
GO:0035854	eosinophil fate commitment	biological process	IDA[12045236]
GO:0045648	positive regulation of erythrocyte differentiation	biological process	IMP[17167422]
GO:0005730	nucleolus	cellular component	IDA
GO:0043066	negative regulation of apoptotic process	biological process	IMP[17167422]; TAS[15967790]
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IDA[2467208]
GO:0007596	blood coagulation	biological process	TAS
GO:0006366	transcription from RNA polymerase II promoter	biological process	IDA[2467208]
GO:0030219	megakaryocyte differentiation	biological process	IMP[10700180]
GO:0001158	enhancer sequence-specific DNA binding	molecular function	IEA
GO:0097067	cellular response to thyroid hormone stimulus	biological process	IDA[19375645]
GO:0001085	RNA polymerase II transcription factor binding	molecular function	IPI[15920471]
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	molecular function	IEA
GO:0097028	dendritic cell differentiation	biological process	IEA
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	biological process	IMP[15701726]

GATA1 related KEGG pathways (count: 0)

GATA1 related BioCarta pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped BioCarta pathways
AHSP_PATHWAY	ahsp pathway	Hemoglobin's Chaperone	The function of hemoglobin in oxygen transport by red blood ...... The function of hemoglobin in oxygen transport by red blood cells requires precise assembly of a tetramer of two beta-subunits and two alpha-units. If too many beta-subunits are present, then all tetramers of beta-subunits are formed that bind oxygen but do not release it when needed. When alpha-subunits are in excess they form precipitates with oxidized heme that damage red blood cells. Red blood cells require a precise coregulation of alpha and beta subunit expression to maintain the proper ratio of the subunits and normal red blood cell function. Generally red blood cells express slightly more alpha than beta-subunits to avoid forming unproductive beta-tetramers (HbH). The slight excess of alpha units are blocked from precipitation by a molecular chaperone, AHSP, alpha-hemoglobin stabilizing protein. Expression of the AHSP gene is coordinately activated with the globin genes and heme biosynthesis genes by the GATA-1 gene involved in erythrocyte differentiation. AHSP blocks precipitation of alpha-units, and promotes the formation of normal productive alpha-beta tetramers (HbA). People with mutation or deletion of the beta-subunit gene have Beta-thalassemias resulting from an over-abundance of alpha subunits and their precipitation. The severity of the phenotype may depend on the AHSP genotype of these individuals and elevating AHSP levels through gene therapy may provide a treatment strategy for beta-thalassemia. More...

GATA1 related Reactome pathways (count: 0)

GATA1 related interactors from protein-protein interaction data in HPRD (count: 18)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
GATA1	SPI1	No	in vitro;in vivo	10364157
GATA1	ZFPM1	No	in vitro;in vivo;yeast 2-hybrid	9230307 , 11675338
GATA1	AKT1	No	in vitro;in vivo	16107690
GATA1	ZBTB16	Yes	in vitro;in vivo	12242665
GATA1	CEBPE	No	in vivo	12202480
GATA1	CREBBP	Yes	in vitro	12496368
GATA1	FLI1	No	in vitro;in vivo;yeast 2-hybrid	12724402
GATA1	HEY1	No	in vitro;in vivo	15314183
GATA1	MED1	No	in vitro	11724781
GATA1	HSPA4	No	in vitro;in vivo	17167422
GATA1	STAT3	No	in vitro;in vivo	15673499
GATA1	ZNF521	No	in vitro	19049973
GATA1	MAPK1	Yes	in vitro	15967790
GATA1	LMO2	No	in vitro;in vivo;yeast 2-hybrid	7568177 , 9209374
GATA1	ZFPM2	No	in vitro;yeast 2-hybrid	10438528
GATA1	CASP3	No	in vitro	17167422
GATA1	MAPK3	No	in vitro	15967790
GATA1	HDAC5	Yes	in vitro;in vivo	14668799

Gene Report

Gene mapped GO terms

Gene mapped BioCarta pathways