
Gene Report
Approved Symbol | HDAC5 |
---|---|
Approved Name | histone deacetylase 5 |
Symbol Alias | KIAA0600, NY-CO-9, FLJ90614 |
Location | 17q21 |
Position | chr17:42154121-42201014 (-) |
External Links |
Entrez Gene: 10014 Ensembl: ENSG00000108840 UCSC: uc002iff.1 HGNC ID: 14068 |
No. of Studies (Positive/Negative) | 3(3/0)
![]() |
Type | Literature-origin |
Name in Literature | Reference | Research Type | Statistical Result | Relation Description | ![]() |
---|---|---|---|---|---|
HDAC5 | Iga, 2007 | patients and normal controls | Levels of HDAC5 and CREB mRNA were significantly higher in d...... Levels of HDAC5 and CREB mRNA were significantly higher in drug-free depressive patients than those of controls More... | ||
histone deacetylase 5 | Hobara, 2010 | patients and normal controls | In MDD, the expression of HDAC2 and -5 mRNA was increased in...... In MDD, the expression of HDAC2 and -5 mRNA was increased in a depressive state, but not in a remissive state, compared to controls. More... | ||
HDAC5 | Belzeaux, 2010 | patients and normal controls | We also observed that variations in other mRNA expression we...... We also observed that variations in other mRNA expression were associated with treatment efficacy or clinical improvement (CREB1, HDAC5, HSPA2, HTR1B, HTR2A, and SLC6A4/5HTT). More... |
Network loading ...
Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus | Protein and Other Molecule | Cell and Molecular Pathway | Neural System | Cognition and Behavior | Symptoms and Signs | Environment | MDD |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
![]() |
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Approved Name | UniportKB | No. of Studies (Positive/Negative) | Source | |
---|---|---|---|---|
Histone deacetylase 5 | Q9UQL6 | 0(0/0) | Gene mapped |
Literature-origin GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0006954 | inflammatory response | biological process | TAS[12711221] |
Gene mapped GO terms | ||||
ID | Name | Type | Evidence | |
---|---|---|---|---|
GO:0010832 | negative regulation of myotube differentiation | biological process | IMP[10983972] | |
GO:0007507 | heart development | biological process | IEA | |
GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | biological process | IDA[16236793]; IMP[10983972] | |
GO:0006342 | chromatin silencing | biological process | TAS[10869435] | |
GO:0006351 | transcription, DNA-dependent | biological process | IEA | |
GO:0046969 | NAD-dependent histone deacetylase activity (H3-K9 specific) | molecular function | IEA | |
GO:0046970 | NAD-dependent histone deacetylase activity (H4-K16 specific) | molecular function | IEA | |
GO:0097372 | NAD-dependent histone deacetylase activity (H3-K18 specific) | molecular function | IEA | |
GO:0046872 | metal ion binding | molecular function | IEA | |
GO:0090051 | negative regulation of cell migration involved in sprouting angiogenesis | biological process | IMP[19351956] | |
GO:0008134 | transcription factor binding | molecular function | IPI[19071119] | |
GO:0030183 | B cell differentiation | biological process | TAS[12711221] | |
GO:0010830 | regulation of myotube differentiation | biological process | ISS | |
GO:0070491 | repressing transcription factor binding | molecular function | IPI[12242305] | |
GO:0005730 | nucleolus | cellular component | IDA | |
GO:0006325 | chromatin organization | biological process | TAS[12711221] | |
GO:0016604 | nuclear body | cellular component | IEA | |
GO:0006338 | chromatin remodeling | biological process | TAS[10220385] | |
GO:0045892 | negative regulation of transcription, DNA-dependent | biological process | TAS[12711221] | |
GO:0005634 | nucleus | cellular component | IDA | |
GO:0032869 | cellular response to insulin stimulus | biological process | NAS[18184930] | |
GO:0005515 | protein binding | molecular function | IPI[10869435] | |
GO:0043393 | regulation of protein binding | biological process | IMP[19071119] | |
GO:0032041 | NAD-dependent histone deacetylase activity (H3-K14 specific) | molecular function | IEA | |
GO:0005829 | cytosol | cellular component | IEA | |
GO:0000118 | histone deacetylase complex | cellular component | TAS[12711221] | |
GO:0005080 | protein kinase C binding | molecular function | IPI | |
GO:0005737 | cytoplasm | cellular component | IDA | |
GO:0045668 | negative regulation of osteoblast differentiation | biological process | IEA | |
GO:0044212 | transcription regulatory region DNA binding | molecular function | IDA[19351956] | |
GO:0003714 | transcription corepressor activity | molecular function | IEA | |
GO:0042220 | response to cocaine | biological process | IEA | |
GO:0002076 | osteoblast development | biological process | IEA | |
GO:0016575 | histone deacetylation | biological process | IDA[10869435] | |
GO:0007219 | Notch signaling pathway | biological process | TAS | |
GO:0005794 | Golgi apparatus | cellular component | IDA | |
GO:0016568 | chromatin modification | biological process | TAS[12711221] | |
GO:0004407 | histone deacetylase activity | molecular function | IDA[10869435] | |
GO:0042113 | B cell activation | biological process | TAS[12711221] | |
GO:0051091 | positive regulation of sequence-specific DNA binding transcription factor activity | biological process | IMP[19071119] | |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | biological process | IMP[19071119] |
Gene mapped BioCarta pathways | ||||
ID | Name | Brief Description | Full Description | |
---|---|---|---|---|
HDAC_PATHWAY | hdac pathway | Control of skeletal myogenesis by HDAC and calcium/calmodulin-dependent kinase (CaMK) | The differentiation of muscle cells is transcriptionally reg...... The differentiation of muscle cells is transcriptionally regulated, in part by the myocyte enhancer factor-2, MEF2. During myogenesis MEF2 binds to MyoD and other basic helix-loop-helix factors to activate transcription of genes involved in muscle cell differentiation. Transcriptional activation by MEF2 is blocked by interaction with HDAC5 and other histone deacetylases. In undifferentiated myoblasts, HDAC5 is present in the nucleus where it binds to MEF2 to block activation of muscle genes. When activated by IGF-1 signaling, CaM kinase phosphorylates HDAC proteins, causing them to be exported from the nucleus, releasing the block on MEF2 transcriptional activation and allowing differentiation to proceed. Transcription cofactors also interact with MEF2 to contribute to gene regulation and myogenesis. The transcriptional regulator NFAT, for example, acts as a cofactor for MEF2 when calcium and calcineurin signaling activate it. There are four members of the Mef2 gene family, Mef2a-2d. Mef2a is expressed in brain, heart and skeletal muscle. Mef2c is involved in myogenesis in cardiac and skeletal muscle. Mef2d is widely expressed, and may be involved in the regulation of T cell function as well as muscle. Several factors regulate Mef2 transcription factors, including Map kinases and histone deacetylase (HDAC) enzymes. Mef2 is phosphorylated by p38 map kinase, and phosphorylation of Mef2c by p38 contributes to skeletal muscle differentiation. BMK-1 (also called Erk5) is another member of the Map kinase family that regulates the activity of Mef2 family members and is unique in that it appears itself to possess a transcriptional activation domain and act as a transcriptional coactivator. Mekk3 disruption prevented normal cardiovascular development in mice and appears to signal through p38 and Mef2c in normal cardiovascular development. More... | |
PGC1A_PATHWAY | pgc1a pathway | Regulation of PGC-1a | Peroxisome proliferator-activated receptor gamma coactivator...... Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1a) is a tissue-specific coactivator that enhances the activity of many nuclear receptors and coordinates transcriptional programs important for energy metabolism and energy homeostasis. Inappropriate increases in PGC-1a activity have been linked to a number of pathological conditions including heart failure and diabetes. PGC-1a is highly expressed in metabolically active tissues including brown fat, skeletal muscle and heart. PGC-1a has been implicated in mitochondrial biogenesis in the heart and increased mitochondrial respiration in brown fat. PGC-1a is a coactivator for many factors including, CBP, Scr-1, PPARa, GR (glucocorticoid receptor), THR (thyroid hormone receptor), several orphan receptors and MEF2. This pathway illustrates two of the cofactor regulatory factors MEF2 and PPARa) and an example orphan receptor feedback inhibition loop. Glut4 is used as an example of the downstream elements leading to changes in metabolism. Ichida et al discovered the ERRa repression of PGC-1a. Their results suggest a novel mechanism of transcriptional control wherein ERR-a can function as a specific molecular repressor of PGC-1a. This suggests that other co-activators might also have specific repressors, adding another layer of combinatorial complexity in transcriptional regulation. Czubryt et al identified PGC-1 a as a key target of the MEF2/HDAC regulatory pathway and demonstrated this pathway's importance in maintenance of cardiac mitochondrial function. The linking of MEF2/HDAC provides an potential explanation for the increase in mitochondrial number observed in response to CaMK signaling. More... | |
CARM_ER_PATHWAY | carm er_pathway | CARM1 and Regulation of the Estrogen Receptor | Several forms of post-translational modification regulate pr...... Several forms of post-translational modification regulate protein activities. Recently, protein methylation by CARM1 (coactivator-associated arginine methyltransferase 1) has been observed to play a key role in transcriptional regulation. CARM1 associates with the p160 class of transcriptional coactivators involved in gene activation by steroid hormone family receptors. CARM1 also interacts with CBP/p300 transcriptional coactivators involved in gene activation by a large variety of transcription factors, including steroid hormone receptors and CEBP. One target of CARM1 is the core histones H3 and H4, which are also targets of the histone acetylase activity of CBP/p300 coactivators. Recruitment of CARM1 to the promoter region by binding to coactivators increases histone methylation and makes promoter regions more accessible for transcription. Another target of CARM1 methylation is a coactivator it interacts with, CBP. Methylation of CBP by CARM1 blocks CBP from acting as a coactivator for CREB and redirects the limited CBP pool in the cell to be available for steroid hormone receptors. Other forms of post-translational protein modification such as phosphorylation are reversible in nature, but as of yet a protein demethylase is not known. The methylation activity of CARM1 modulates the activity of specific transcriptional regulators. CARM1 acts as a coactivator for the myogenic transcription factor Mef2c, and is necessary for normal muscle cell differentiation. The estrogen receptor is another transcription factor that uses CARM1 as one of several coactivators, acting synergistically with CBP through the Grip1 member of the p160 family of coactivators. The interaction of estrogen receptor with various ligand-dependent coactivators may produce the tissue selective response of some estrogen receptor ligands like tamoxifen. More... | |
ETS_PATHWAY | ets pathway | METS affect on Macrophage Differentiation | Terminal differentiation of cells is often accompanied by re...... Terminal differentiation of cells is often accompanied by repression of cellular proliferation, suggesting that there is a mechanism by which these cellular functions are coordinated. Macrophage differentiation is one model system in which this occurs; as macrophages differentiate, they also stop proliferating. Transcriptional regulation plays a key role in cell cycle progression as well as many differentiation processes. Ras stimulates cell cycle progression in part through Ets transcription factors that bind to cell cycle regulatory genes to activate their expression. Ets transcription factors also help to induce early macrophage differentiation. The activation of Ras signaling by M-CSF activates transcription of genes involved in differentiation through the coordinate expression of both Ets factors and AP-1. Other genes involved in cell cycle regulation involved the coordinate action of E2F-1 and Ets transcription factors. Mets is a factor related in sequence to Ets2 that is upregulated during macrophage differentiation. Increased expression of the Mets protein during macrophage differentiation allows the creation of heterodimers with DP103 to act as transcriptional repressors of cell cycle progression genes, recruiting corepressor to promoters they interact with. DP103 is a gene previously identified as an RNA helicase involved in RNA processing that interacts with EBNA factors from Epstein Barr Virus. The transcriptional repression involving Mets with DP103 is selective, and does not involve all Ets regulated genes. While cell cycle genes are repressed by Mets, other gene activated by Ets factors such as those involved in differentiation are not repressed by Mets. The transcriptional repression by Mets also involved members of the Rb family of tumor suppressors, such as p107 and p130. This requirement for additional factors involved in regulating proliferation may allow for another level of control on cell proliferation and coordination with differentiation. More... |

Gene | Interactor | Interactor in MK4MDD? | Experiment Type | PMID | |
---|---|---|---|---|---|
HDAC5 | CAMK1 | No | in vitro | 15367659 , 11114197 , 11081517 | |
HDAC5 | HR | No | in vivo;yeast 2-hybrid | 11641275 | |
HDAC5 | YWHAE | Yes | in vitro;in vivo;yeast 2-hybrid | 10869435 , 11114197 | |
HDAC5 | MEF2D | No | in vitro;in vivo | 12896970 , 10737771 | |
HDAC5 | GCM1 | No | in vivo | 16528103 | |
HDAC5 | GNB1 | No | yeast 2-hybrid | 16221676 | |
HDAC5 | NCOR1 | No | in vitro;yeast 2-hybrid | 10640275 | |
HDAC5 | GATA2 | No | in vitro;in vivo | 11567998 | |
HDAC5 | HDAC5 | Yes | in vivo | 10898795 | |
HDAC5 | EEF1G | No | yeast 2-hybrid | 16169070 | |
HDAC5 | PRKD1 | No | in vitro | 15367659 , 11114197 , 11081517 | |
HDAC5 | HDAC3 | No | in vitro;in vivo | 10220385 , 11804585 , 11466315 | |
HDAC5 | CBX5 | No | in vitro | 12242305 | |
HDAC5 | SFN | No | in vivo;yeast 2-hybrid | 15367659 | |
HDAC5 | BRMS1 | No | in vivo | 16919237 | |
HDAC5 | DDX20 | No | in vitro;in vivo | 12007404 | |
HDAC5 | UBC | No | in vitro;in vivo | 12354939 | |
HDAC5 | GABARAP | No | yeast 2-hybrid | 16169070 | |
HDAC5 | PHB2 | No | in vitro;in vivo | 15140878 | |
HDAC5 | ZBTB16 | Yes | in vitro;in vivo | 15467736 , 11929873 | |
HDAC5 | KLF4 | Yes | in vivo | 18768922 | |
HDAC5 | NCOR2 | No | in vitro;in vivo;yeast 2-hybrid | 10869435 | |
HDAC5 | MEF2A | No | in vitro;in vivo | 10748098 , 10737771 | |
HDAC5 | BCOR | No | in vivo | 10898795 | |
HDAC5 | NFKB2 | No | in vitro;in vivo | 12917325 | |
HDAC5 | SUV39H1 | No | in vivo | 12242305 | |
HDAC5 | MEF2C | No | in vitro | 10737771 | |
HDAC5 | CIITA | No | in vivo | 15964851 | |
HDAC5 | RUNX3 | No | in vitro;in vivo | 15138260 | |
HDAC5 | CAMTA2 | No | in vivo | 16678093 | |
HDAC5 | GATA1 | Yes | in vitro;in vivo | 14668799 | |
HDAC5 | BCL6 | Yes | in vitro;in vivo | 11929873 | |
HDAC5 | ANKRD11 | No | in vitro | 15184363 | |
HDAC5 | ANKRA2 | No | in vitro;in vivo | 15964851 | |
HDAC5 | NRIP1 | No | in vitro;in vivo | 15060175 | |
HDAC5 | YWHAB | No | in vivo | 10869435 | |
HDAC5 | RFXANK | No | in vitro;in vivo | 15964851 |