Gene Report

Basic Information

Approved Symbol	CAD
Approved Name	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Location	2p22-p21
Position	chr2:27440258-27466654 (+)
External Links	Entrez Gene: 790 Ensembl: ENSG00000084774 UCSC: uc002rji.3 HGNC ID: 1424
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between CAD and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	Tochigi, 2008	patients and normal controls		Genes differentially expressed in major depression Genes differentially expressed in major depression

Positive relationships between CAD and other components at different levels (count: 0)

Positive relationship network of CAD in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between CAD and MDD (count: 0)

Negative relationships between CAD and other components at different levels (count: 0)

CAD related SNPs in MK4MDD (count: 0)

CAD related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
CAD protein	P27708	0(0/0)	Gene mapped

CAD related GO terms (count: 40)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0032553	ribonucleotide binding	molecular function	ISS

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0014075	response to amine stimulus	biological process	IEA
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	biological process	ISS
GO:0042802	identical protein binding	molecular function	ISS
GO:0043234	protein complex	cellular component	IEA
GO:0007595	lactation	biological process	IEA
GO:0035690	cellular response to drug	biological process	IEA
GO:0071364	cellular response to epidermal growth factor stimulus	biological process	IEA
GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	molecular function	ISS; TAS
GO:0006541	glutamine metabolic process	biological process	ISS
GO:0043195	terminal bouton	cellular component	ISS
GO:0006228	UTP biosynthetic process	biological process	IEA
GO:0005829	cytosol	cellular component	IDA[15890648]; TAS
GO:0044281	small molecule metabolic process	biological process	TAS
GO:0031000	response to caffeine	biological process	IEA
GO:0019899	enzyme binding	molecular function	IPI[15326225]
GO:0046777	protein autophosphorylation	biological process	ISS
GO:0005524	ATP binding	molecular function	ISS
GO:0009790	embryo development	biological process	IEA
GO:0051414	response to cortisol stimulus	biological process	IEA
GO:0070409	carbamoyl phosphate biosynthetic process	biological process	IEA
GO:0044205	'de novo' UMP biosynthetic process	biological process	IEA
GO:0004070	aspartate carbamoyltransferase activity	molecular function	ISS; TAS
GO:0006206	pyrimidine nucleobase metabolic process	biological process	TAS
GO:0070335	aspartate binding	molecular function	ISS
GO:0031100	organ regeneration	biological process	IEA
GO:0043025	neuronal cell body	cellular component	ISS
GO:0018107	peptidyl-threonine phosphorylation	biological process	ISS
GO:0055086	nucleobase-containing small molecule metabolic process	biological process	TAS
GO:0004151	dihydroorotase activity	molecular function	ISS; TAS
GO:0017144	drug metabolic process	biological process	ISS
GO:0007565	female pregnancy	biological process	IEA
GO:0046134	pyrimidine nucleoside biosynthetic process	biological process	TAS
GO:0033574	response to testosterone stimulus	biological process	IEA
GO:0046872	metal ion binding	molecular function	IEA
GO:0016363	nuclear matrix	cellular component	IDA[9525610]
GO:0006543	glutamine catabolic process	biological process	IEA
GO:0042995	cell projection	cellular component	ISS
GO:0004672	protein kinase activity	molecular function	ISS
GO:0005634	nucleus	cellular component	IDA[15890648]

CAD related KEGG pathways (count: 2)

ID	Name	Brief Description
Gene mapped KEGG pathways
hsa00240	pyrimidine metabolism	Pyrimidine metabolism
hsa00250	alanine aspartate_and_glutamate_metabolism	Alanine, aspartate and glutamate metabolism

CAD related BioCarta pathways (count: 0)

CAD related Reactome pathways (count: 2)

ID	Name	Description
Gene mapped Reactome pathways
REACT_957	pyrimidine metabolism	The events of human pyrimidine metabolism are conveniently, ...... The events of human pyrimidine metabolism are conveniently, if somewhat arbitrarily, grouped into four pathways: de novo synthesis of the pyrimidine ring and its conversion to uridine 5'-monophosphate (UMP), the biosynthesis of other pyrimidine ribo- and deoxyribonucleotides, pyrimidine salvage reactions, and pyrimidine catabolism. De novo synthesis of the pyrimidine ring and its conversion to UMP. The pyrimidine base orotate is synthesized from glutamine, bicarbonate, and aspartate. Orotate reacts with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) and is then decarboxylated to form the pyrimidine nucleotide UMP. Pyrimidine biosynthesis. Pyrimidine ribo- and deoxyribonucleotide di- and triphosphates are synthesized, both from UMP and from pyrimidine ribonucleotide monophosphates generated in salvage reactions. Pyrimidine salvage reactions. Pyrimidine nucleosides and free bases generated by DNA and RNA breakdown are converted to nucleotide monophosphates. Pyrimidine catabolism. The pyrimidine bases thymine and uracil are degraded to beta-aminoisobutyrate and beta-alanine, respectively, which are excreted from the body. More...
REACT_1698	metablism of_nucleotides	Nucleotides and their derivatives are used for short-term en...... Nucleotides and their derivatives are used for short-term energy storage (ATP, GTP), for intra- and extra-cellular signaling (cAMP; adenosine), as enzyme cofactors (NAD, FAD), and for the synthesis of DNA and RNA. Most dietary nucleotides are consumed by gut flora; the human body's own supply of these molecules is synthesized de novo. Additional metabolic pathways allow the interconversion of nucleotides, the salvage and reutilization of nucleotides released by degradation of DNA and RNA, and the catabolism of excess nucleotides. These pathways are regulated to control the total size of the intracellular nucleotide pool, to balance the relative amounts of individual nucleotides, and to couple the synthesis of deoxyribonucleotides to the onset of DNA replication (S phase of the cell cycle). These pathways are also of major clinical interest as they are the means by which nucleotide analogues used as anti-viral and anti-tumor drugs are taken up by cells, activated, and catabolized. More...

CAD related interactors from protein-protein interaction data in HPRD (count: 7)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
CAD	PPP1CA	No	in vitro	4092695
CAD	YWHAG	No	in vivo	15324660
CAD	PPP2CA	No	in vitro	4092695
CAD	MAPK1	Yes	in vitro	12438317
CAD	PRKACA	No	in vitro	11986331 , 4092695
CAD	CASP3	No	in vitro	11854437
CAD	CAD	Yes	in vitro;in vivo	14523024 , 11986331 , 12438317

Gene Report

Literature-origin GO terms

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways