KEGG Pathway Report
Basic Information
| ID |
hsa04914
|
| Name |
progesterone mediated_oocyte_maturation
|
| Brief Description |
Progesterone-mediated oocyte maturation
|
| Full Description |
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP. |
hsa04914 related genes in MK4MDD (count: 16)
| Approved Symbol |
Approved Name |
Type |
No. of Studies (Positive/Negative) |
| PDE3A |
phosphodiesterase 3A, cGMP-inhibited |
Literature-origin
|
1(1/0) |
| FZR1 |
fizzy/cell division cycle 20 related 1 (Drosophila) |
Literature-origin
|
1(1/0) |
| HSP90AB1 |
heat shock protein 90kDa alpha (cytosolic), class B member 1 |
Protein mapped
|
0(0/0) |
| GNAI3 |
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 |
SNP mapped
|
0(0/0) |
| INS |
insulin |
Literature-origin; Protein mapped
|
1(1/0) |
| PIK3R1 |
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
Literature-origin
|
1(1/0) |
| MAPK12 |
mitogen-activated protein kinase 12 |
Literature-origin
|
1(1/0) |
| PRKACB |
protein kinase, cAMP-dependent, catalytic, beta |
Protein mapped
|
0(0/0) |
| MAPK1 |
mitogen-activated protein kinase 1 |
Literature-origin
|
2(2/0) |
| PRKACA |
protein kinase, cAMP-dependent, catalytic, alpha |
Protein mapped
|
0(0/0) |
| ADCY7 |
adenylate cyclase 7 |
Literature-origin; SNP mapped
|
2(2/0) |
| MAPK8 |
mitogen-activated protein kinase 8 |
Literature-origin
|
1(1/0) |
| KRAS |
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog |
Protein mapped
|
0(0/0) |
| ADCY8 |
adenylate cyclase 8 (brain) |
Literature-origin
|
2(2/0) |
| ADCY3 |
adenylate cyclase 3 |
Literature-origin; SNP mapped
|
1(0/1) |
| ADCY9 |
adenylate cyclase 9 |
SNP mapped
|
0(0/0) |
