Neurobiological Component Report

Basic Information

Name	P300
Description	The P300 (P3) wave is an event related potential (ERP) elicited by infrequent, task-relevant stimuli. It is considered to be an endogenous potential as its occurrence links not to the physical attributes of a stimulus but to a person's reaction to the stimulus. More specifically, the P300 is thought to reflect processes involved in stimulus evaluation or categorization. When recorded by electroencephalography (EEG), it surfaces as a positive deflection in voltage with a latency (delay between stimulus and response) of roughly 300 to 600 ms. The signal is typically measured most strongly by the electrodes covering the parietal lobe.
Picture	From Wiki.
No. of Studies (Positive/Negative)	18 (17/1)

Positive relationship between P300 and MDD (count: 13)

Name in Literature	Reference	Research Type	Relation Description
P3	Dai, 2009	patients and normal controls	The MDD participants had larger P3 amplitude for sad cue tha...... The MDD participants had larger P3 amplitude for sad cue than for other face cues, smaller P3 amplitude for sad faces in the invalid cue condition compared with NC participants, and smaller P3 amplitude for happy faces in the valid cue condition compared with other groups. More...
P300	Ortiz Alonso, 2002	patients only	The results shown an increase of P300 latency in depressive ...... The results shown an increase of P300 latency in depressive patients during auditory and visual tasks. More...
P300	Karaaslan, 2003	patients and normal controls	Pretreatment P300 latencies were significantly prolonged bot...... Pretreatment P300 latencies were significantly prolonged both in patients with and without psychotic features compared to controls. More...
P3	Pause, 2003	patients and normal controls	At the beginning of the therapy, visual stimulus processing ...... At the beginning of the therapy, visual stimulus processing was attenuated in depressive subjects at a relatively late processing level (reduced amplitudes of the P3 and pSW in response to colors and emotional slides). More...
P300	Ortiz, 2003	patients and normal controls	The depressive patients showed increased event-related poten...... The depressive patients showed increased event-related potentials (P300) between 300-700 milliseconds registered in Pz. More...
P300	Mao, 2005	patients and normal controls	The amplitude of P300 elicited in the match condition was de...... The amplitude of P300 elicited in the match condition was decreased in the patient group at P3 and P4 electrodes, but its latency did not differ from the control group. More...
P3	Perez-Edgar, 2006	high-risk people and normal controls	Children of parents with COD (childhood-onset depression) sh...... Children of parents with COD (childhood-onset depression) showed larger P3 and slow wave amplitudes in anterior scalp sites, particularly during the affective Posner task. More...
P300	Neuhaus, 2007	patients only	In VNS (vagus nerve stimulation) responders only, P300 at mi...... In VNS (vagus nerve stimulation) responders only, P300 at midline electrodes Fz and Cz was significantly increased and correlated with HAMD scores. In our sample, enhancement of P300 distinguished VNS responders from non-responders 10 weeks after therapy onset. More...
P300	Kemp, 2009	patients and normal controls	A subsequent reduction and delay in the P300 was also reveal...... A subsequent reduction and delay in the P300 was also revealed for MDD indicating that the pronounced lack of discrimination in clinical depression may also lead to impaired stimulus evaluation. More...
P3	Ruchsow, 2008	patients and normal controls	MDD patients showed a specifically reduced Nogo-P3 while the...... MDD patients showed a specifically reduced Nogo-P3 while the Nogo-N2 and the P3b in Go trials were unaffected. More...
P300	Kemp, 2010	patients and normal controls	The key findings were a reduction in the P300 to targets in ...... The key findings were a reduction in the P300 to targets in patients with melancholia, relative to patients with non-melancholia and controls. More...
P3	Yang, 2011	patients only	MDD patients showed reduced P3 amplitudes to negative compar...... MDD patients showed reduced P3 amplitudes to negative compared with positive target stimuli. More...
P3	Dai, 2011	patients and normal controls	The MDD participants had a larger P3 amplitude for sad faces...... The MDD participants had a larger P3 amplitude for sad faces in the positive priming condition compared with the other groups, and smaller P3 amplitude for sad faces in negative priming condition compared with other faces. More...

Positive relationships between P300 and other components at different levels (count: 7)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description
Name in Literature	Related Components
P300		rs112439044(rs112439044)	SNP	Xu, 2010	patients and normal controls	P-value=0.009	The P300 latency was associated with miR-30e ss178077483 (rs...... The P300 latency was associated with miR-30e ss178077483 (rs112439044) genotypes and the individuals with the C/T genotype have a longer P300 latency than those carrying the C/C genotype (P=0.009). More...
P3		Protein S100-B(S100B)	protein	Dietrich, 2004	patients only		Patients with increased S100B serum levels (n=6) showed a no...... Patients with increased S100B serum levels (n=6) showed a normal N2- and P3-amplitude in contrast to a reduced N2- and P3-amplitude in patients with normal S100B serum levels (n=6). More...
P300		Cognitive performance(impaired stimulus evaluation)	cognition and behavior	Kemp, 2009	patients and normal controls		A subsequent reduction and delay in the P300 was also reveal...... A subsequent reduction and delay in the P300 was also revealed for MDD indicating that the pronounced lack of discrimination in clinical depression may also lead to impaired stimulus evaluation. More...
P300		Executive functions(lack of discrimination)	cognition and behavior	Kemp, 2009	patients and normal controls		A subsequent reduction and delay in the P300 was also reveal...... A subsequent reduction and delay in the P300 was also revealed for MDD indicating that the pronounced lack of discrimination in clinical depression may also lead to impaired stimulus evaluation. More...
P300		Psychotic symptoms(psychotic features)	symptoms	Karaaslan, 2003	patients and normal controls		Pretreatment P300 amplitudes were significantly decreased on...... Pretreatment P300 amplitudes were significantly decreased only in the patients with psychotic features. More...
P3		Depressed mood(depressive symptomatology)	symptoms	Krompinger, 2009	high-risk people and normal controls		Results indicated that across all trials, subjects high on d...... Results indicated that across all trials, subjects high on depressive symptomatology exhibited larger P3s in response to negative compared to positive stimuli. More...
P3		Suicide(suicide intent)	symptoms	Jandl, 2010	patients only		Decreases in P3 were also more pronounced in the HAS and SAS...... Decreases in P3 were also more pronounced in the HAS and SAS groups in study 1 and in the HAS group in study 2, 'novel' and 'target' condition. Both EDA an P3 habituated faster in MDD patients with a history of attempted suicide. More...

Positive relationship network of P300 in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between P300 and MDD (count: 0)

Negative relationships between P300 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description
Name in Literature	Related Components
P300		DRD2(DRD2)	gene	Chen, 2002	patients only		The results demonstrate that neither polymorphism is associa...... The results demonstrate that neither polymorphism is associated with P300 amplitude or latency, even after gender analysis. We suggest that these two DRD2 polymorphisms have no major effects on P300 components for the Chinese population. More...