Study Report
Reference
| Citation | Hou, 2006 PubMed |
| Full Info | Hou, C., Jia, F., Liu, Y. and Li, L. (2006) CSF serotonin, 5-hydroxyindolacetic acid and neuropeptide Y levels in severe major depressive disorder. Brain Res, 1095, 154-158.
|
Study
| Hypothesis or Background |
Serotonin (5-HT) and 5-hydroxyindolacetic acid (5-HIAA) have been the putative markers of MDD. Neuropeptide Y (NPY) may have an important role in the pathophysiology of major depressive disorder (MDD). However, direct measures of cerebrospinal fluid (CSF) 5-HT and NPY in severe MDD have been lacking. In the present study, we examined CSF 5-HT, 5-HIAA and NPY levels and correlate them with gender and suicidal behavior of severe major depressive disorder.
|
| Sample Information | Forty drug-free subjects with a severe major depressive disorder and forty control subjects |
|---|
| Method Detail | Subjects underwent lumber puncture and psychiatric evaluation. Cerebrospinal fluid levels of 5-HT, 5-HIAA and NPY were assayed by enzyme-linked immunosorbent assay (ELISA) test. The relationships among 5-HT, 5-HIAA, NPY and clinical variables were statistically evaluated. |
| Method Keywords | cerebrospinal fluid analysis |
| Result | There were no differences between severe major depressive disorder and controls in all parameters measured. In severe MDD group, significantly lower CSF 5-HT and higher 5-HT turnover (5-HIAA/5-HT) were found in female patients compared with male patients. The patients with intense suicidal intents and suicidal attempts had significantly lower CSF 5-HT compared to patients with nonsuicidal intents. Additionally, significantly lower CSF NPY was found in first episode depressed patients compared with recurrent depressed patients. Gender-related difference in CSF 5-HT implied a female preponderance in major depression to some extent. |
| Conclusions | Cerebrospinal fluid 5-HT levels and 5-HT turnover (5-HIAA/5-HT) could be valuable tools for prediction of suicidality and potential markers for evaluating major depressive disorder. NPY was perhaps a marker for first episode depression. |
Relationships reported by
Hou, 2006
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
Serotonin (serotonin (5-HT)) |
molecule |
|
significantly lower CSF(cerebrospinal fluid) NPY was found in first episode depressed patients compared with recurrent depressed patients |
Positive
|
|
Suicide (suicidal intents)
|
symptoms |
Serotonin (serotonin (5-HT)) |
molecule |
|
The patients with intense suicidal intents and suicidal attempts had significantly lower CSF(cerebrospinal fluid) 5-HT compared to patients with nonsuicidal intents. |
Positive
|
