Molecule Report

Name	Serotonin
Description	A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families ( RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
MeSH ID	D012701
No. of Studies (Positive/Negative)	12(12/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
serotonin	Agren, 1994	patients and normal controls		Decreased uptake of [11C]5-HTP (the direct precursors in the...... Decreased uptake of [11C]5-HTP (the direct precursors in the synthetic pathways to serotonin) over the blood-brain barrier in depression (which is not altered by dietary tryptophan depletion in healthy volunteers). More...
serotonin	Fajardo, 2003	patients and normal controls		There was a reduction in serotonin turnover rate indicated b...... There was a reduction in serotonin turnover rate indicated by an increase in the ratio serotonin/5-hydroxyindoleacetic acid, but not in that of dopamine, in lymphocytes of major depression patients. More...
serotonin	Rosa-Neto, 2004	patients and normal controls		Compared with age- and sex-matched controls, normalized K*(a...... Compared with age- and sex-matched controls, normalized K*(an index of serotonin synthesis) was significantly decreased bilaterally in female patients with MD in the anterior cingulate cortex, in the left anterior cingulate cortex in male patients with MD, and in the left mesial temporal cortex in male and female patients with MD (P<.001 for all). More...
serotonin	Mata, 2005	patients and normal controls		Also there was a relative greater concentration of noradrena...... Also there was a relative greater concentration of noradrenaline than serotonin in the lymphocytes of the patients, as indicated by the ratio noradrenaline/serotonin. More...
serotonin (5-HT)	Hou, 2006	patients and normal controls		significantly lower CSF(cerebrospinal fluid) NPY was found i...... significantly lower CSF(cerebrospinal fluid) NPY was found in first episode depressed patients compared with recurrent depressed patients More...
5-HT	Ljubicic, 2007	patients and normal controls		The significant increase in platelet 5-HT values were found ...... The significant increase in platelet 5-HT values were found in female (p=0.01) and male (p=0.029) depressed patients during long compared to short period. More...
5-HT	Barton, 2008	patients and normal controls		Brain serotonin turnover was significantly elevated in unmed...... Brain serotonin turnover was significantly elevated in unmedicated patients with MDD compared with healthy subjects (mean [SD] internal jugular venoarterial 5-hydroxyindoleacetic acid plasma concentration difference, 4.4 [4.3] vs 1.6 [2.4] nmol/L, respectively; P = .003). More...
5-HT	Li, 2010	patients and normal controls		We found that the level of 5-HT was decreased in peripheral ...... We found that the level of 5-HT was decreased in peripheral serum, and the expression of 5-HT(1a) receptor was also decreased in peripheral lymphocytes of major depression patients More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
5-HT		SLC6A4(5-HTT)	gene	Barton, 2008	patients and normal controls	P-value=0.04	Analysis of the influence of the 5-HTT genotype in MDD indi...... Analysis of the influence of the 5-HTT genotype in MDD indicated that carriage of the s allele compared with the l allele was associated with greater than a 2-fold increase in brain serotonin turnover (mean [SD] internal jugular venoarterial 5-hydroxyindoleacetic acid plasma concentration difference, 6.5 [4.7] vs 2.7 [2.9] nmol/L, respectively; P = .04). More...
serotonin		SLC6A4(5-HTTLPR)	gene	Eker, 2011	patients and normal controls		It seems that decreased neurogenesis by effects of reduced s...... It seems that decreased neurogenesis by effects of reduced serotoninergic transmission may be responsible for smaller hippocampal volumes observed in S/S homozygous depressed patients. More...
serotonin		medial prefrontal cortex (MPFC)(medial prefrontal cortex)	brain morphology and function	Agren, 1994	patients and normal controls		An increased utilization of [11C]5-HTP (the direct precursor...... An increased utilization of [11C]5-HTP (the direct precursors in the synthetic pathways to serotonin), in the lower region of the medial prefrontal cortex, mainly of the left side. More...
serotonin		Hippocampus(hippocampal volumes)	brain morphology and function	Eker, 2011	patients and normal controls		It seems that decreased neurogenesis by effects of reduced s...... It seems that decreased neurogenesis by effects of reduced serotoninergic transmission may be responsible for smaller hippocampal volumes observed in S/S homozygous depressed patients. More...
serotonin		Suicide(suicide)	symptoms	Austin, 2002	patients and normal controls	P-value < 0.01	The mean total length of serotonin transporter-immunoreactiv...... The mean total length of serotonin transporter-immunoreactive axons per unit area was unchanged in layers 2 and 4 of area 46 in the depressed suicide subjects compared to controls, but was significantly (P < 0.01) decreased by 24% in layer 6 in the depressed suicide group. More...
serotonin (5-HT)		Suicide(suicidal intents)	symptoms	Hou, 2006	patients and normal controls		The patients with intense suicidal intents and suicidal atte...... The patients with intense suicidal intents and suicidal attempts had significantly lower CSF(cerebrospinal fluid) 5-HT compared to patients with nonsuicidal intents. More...
5HT		Suicide(suicide attempt)	symptoms	Roggenbach, 2007	patients and normal controls		Mean platelet 5HT concentration was significantly lower in s...... Mean platelet 5HT concentration was significantly lower in suicidal inpatients when compared to nonsuicidal depressed patients More...
serotonin (5-HT)		Depressed mood(lowering of mood)	symptoms	van der Veen, 2007	high-risk people and normal controls		The present study examined the effects of acute tryptophan (...... The present study examined the effects of acute tryptophan (Trp) depletion (ATD), a well-recognized method to lower central serotonin (5-HT) metabolism, on brain activation during a facial emotion perception task. In the FH+(volunteers with a positive family history of unipolar depression) group, depletion led to the expected lowering of mood More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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