Gene Report

Basic Information

Approved Symbol	RGS18
Approved Name	regulator of G-protein signaling 18
Previous Name	"regulator of G-protein signalling 18"
Symbol Alias	RGS13
Location	1q31.2
Position	chr1:192153685-192154945 (+)
External Links	Entrez Gene: 64407 Ensembl: ENSG00000150681 UCSC: uc001gsg.3 HGNC ID: 14261
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between RGS18 and MDD (count: 0)

Positive relationships between RGS18 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
RGS18		Suicide(suicide attempt)	symptoms	Schosser A, 2011	patients only	P-value<5e-6	For the discrete trait of suicide attempt, SNPs in KIAA1244 ...... For the discrete trait of suicide attempt, SNPs in KIAA1244 and RGS18 attained p-values of <5e-6. More...

Positive relationship network of RGS18 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between RGS18 and MDD (count: 0)

Negative relationships between RGS18 and other components at different levels (count: 0)

RGS18 related SNPs in MK4MDD (count: 0)

RGS18 related proteins in MK4MDD (count: 0)

RGS18 related GO terms (count: 7)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005096	GTPase activator activity	molecular function	IBA
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	biological process	IEA
GO:0009968	negative regulation of signal transduction	biological process	IEA
GO:0005737	cytoplasm	cellular component	IBA
GO:0005886	plasma membrane	cellular component	IBA
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IEA
GO:0043547	positive regulation of GTPase activity	biological process	IEA

RGS18 related KEGG pathways (count: 0)

RGS18 related BioCarta pathways (count: 0)

RGS18 related Reactome pathways (count: 0)

RGS18 related interactors from protein-protein interaction data in HPRD (count: 4)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
RGS18	GNAI3	No	in vitro	11955952 , 11563974
RGS18	GNAI1	Yes	in vitro	11955952
RGS18	GNAQ	No	in vitro	11955952
RGS18	GNAI2	No	in vitro	11955952

Gene Report

Gene mapped GO terms