Gene Report

Basic Information

Approved Symbol	ARL4C
Approved Name	ADP-ribosylation factor-like 4C
Previous Symbol	ARL7
Previous Name	ADP-ribosylation factor-like 7
Symbol Alias	LAK
Location	2q37.2
Position	chr2:235401685-235405693 (-)
External Links	Entrez Gene: 10123 Ensembl: ENSG00000188042 UCSC: uc002vvn.3 HGNC ID: 698
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between ARL4C and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
ARL7	Sequeira A, 2009	patients and nomal controls	Group: P-value=0.001, F=10.5; Substance: P-value=0.009, F=8.9	Genes differentially expressed after an ANCOVA analysis betw...... Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). More...

Positive relationships between ARL4C and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
ARL7		Suicide(suicide)	symptoms	Sequeira A, 2009	patients and nomal controls	Group: P-value=0.001, F=10.5; Substance: P-value=0.009, F=8.9	Genes differentially expressed after an ANCOVA analysis betw...... Genes differentially expressed after an ANCOVA analysis between the three groups(C = control, S = suicide, SMD = suicide with major depression). More...

Positive relationship network of ARL4C in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between ARL4C and MDD (count: 0)

Negative relationships between ARL4C and other components at different levels (count: 0)

ARL4C related SNPs in MK4MDD (count: 0)

ARL4C related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
ADP-ribosylation factor-like protein 4C	P56559	0(0/0)	Gene mapped

ARL4C related GO terms (count: 12)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0032553	ribonucleotide binding	molecular function	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005886	plasma membrane	cellular component	IDA
GO:0005515	protein binding	molecular function	IPI[17398095]
GO:0043014	alpha-tubulin binding	molecular function	IDA[19409876]
GO:0005525	GTP binding	molecular function	IEA
GO:0006184	GTP catabolic process	biological process	TAS[10462049]
GO:0030175	filopodium	cellular component	IEA
GO:0032456	endocytic recycling	biological process	IDA[19409876]
GO:0003924	GTPase activity	molecular function	TAS[10462049]
GO:0005737	cytoplasm	cellular component	IDA
GO:0005634	nucleus	cellular component	TAS[10462049]
GO:0007264	small GTPase mediated signal transduction	biological process	IEA

ARL4C related KEGG pathways (count: 0)

ARL4C related BioCarta pathways (count: 0)

ARL4C related Reactome pathways (count: 0)

ARL4C related interactors from protein-protein interaction data in HPRD (count: 1)

Gene Report

Literature-origin GO terms

Gene mapped GO terms